Human NK cells, their receptors and function

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

(2021) Siroon Bekkering et al.   Annual Review of Immunology

TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection

(2021) Allison M. Owen et al.   Frontiers in Immunology

Tissue Determinants of Human NK Cell Development, Function, and Residence

(2020) Pranay Dogra et al.   CELL

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

(2020) Oisín Huhn et al.   Nature Communications

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

(2020) Bérengère de Laval et al.   Cell Stem Cell

Glucocorticoids and the cytokines IL-12, IL-15 and IL-18 present in the tumor microenvironment induce PD-1 expression on human Natural Killer cells

(2020) Linda Quatrini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy

(2020) Raynier Devillier et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multidimensional analyses of donor memory-like NK cells reveal new associations with response after adoptive immunotherapy for leukemia

(2020) Melissa M. Berrien-Elliott et al.   Cancer Discovery

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

(2020) Simona Sivori et al.   Frontiers in Immunology

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)

(2020) Samantha Barnes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling

(2020) Dejene M. Tufa et al.   Science Immunology

Natural killers or ILC1s? That is the question

(2020) Cyril Seillet et al.   CURRENT OPINION IN IMMUNOLOGY

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor

(2019) Nicola Tumino et al.   INTERNATIONAL JOURNAL OF CANCER

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3

(2019) Maho Nagasawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Natural Cytotoxicity Receptors in Health and Disease

(2019) Alexander David Barrow et al.   Frontiers in Immunology

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

(2019) Daniela Pende et al.   Frontiers in Immunology

The Interaction Between Two Worlds: MicroRNAs and Toll-Like Receptors

(2019) Recep Bayraktar et al.   Frontiers in Immunology

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

(2019) Massimo Vitale et al.   Frontiers in Immunology

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

(2019) Aimee Merino et al.   JOURNAL OF CLINICAL INVESTIGATION

Human NK Cell Development: One Road or Many?

(2019) Frank Cichocki et al.   Frontiers in Immunology

NK Cell-Based Immunotherapy for Hematological Malignancies

(2019) Simona Sivori et al.   Journal of Clinical Medicine

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

(2018) Frank Vari et al.   BLOOD

NKG2D and its ligands in cancer

(2018) Payal Dhar et al.   CURRENT OPINION IN IMMUNOLOGY

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

(2018) Quirin Hammer et al.   NATURE IMMUNOLOGY

Distinct human circulating NKp30+FcεRIγ+CD8+T cell population exhibiting high natural killer-like antitumor potential

(2018) Margareta P. Correia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

(2018) Lucas Ferrari de Andrade et al.   SCIENCE

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia

(2018) Franco Locatelli et al.   TRENDS IN IMMUNOLOGY

Late Development of FcεRγneg Adaptive Natural Killer Cells Upon Human Cytomegalovirus Reactivation in Umbilical Cord Blood Transplantation Recipients

(2018) Letizia Muccio et al.   Frontiers in Immunology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway

(2018) Luxi Chen et al.   IMMUNITY

Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells

(2018) Alexander Rölle et al.   Cell Reports

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection

(2018) Daniela Pende et al.   CLINICAL IMMUNOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8

(2017) Martina Molgora et al.   IMMUNOLOGICAL REVIEWS

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

(2017) Silvia Pesce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: Human CD49e−NK Cells Are Tissue Resident in the Liver

(2017) Han Xian Aw Yeang et al.   JOURNAL OF IMMUNOLOGY

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

(2017) Martina Molgora et al.   NATURE

‘ILC-poiesis’: generating tissue ILCs from naïve precursors

(2017) James P. Di Santo et al.   Oncotarget

KIR3DS1-Mediated Recognition of HLA-*B51: Modulation of KIR3DS1 Responsiveness by Self HLA-B Allotypes and Effect on NK Cell Licensing

(2017) Simona Carlomagno et al.   Frontiers in Immunology

Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells

(2017) Steven D. Scoville et al.   Frontiers in Immunology

Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells

(2017) Sebastian Lunemann et al.   Scientific Reports

Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver

(2016) Cathal Harmon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets

(2016) Steven D. Scoville et al.   IMMUNITY

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

(2016) Wilfredo F Garcia-Beltran et al.   NATURE IMMUNOLOGY

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

(2016) Rizwan Romee et al.   Science Translational Medicine

Regulation of NKG2D Expression and Signaling by Endocytosis

(2016) Rosa Molfetta et al.   TRENDS IN IMMUNOLOGY

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

(2016) Lisa L. Liu et al.   Cell Reports

NKp80 Defines a Critical Step during Human Natural Killer Cell Development

(2016) Aharon G. Freud et al.   Cell Reports

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver

(2016) Kerstin A. Stegmann et al.   Scientific Reports

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing   +T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

(2015) L. Muccio et al.   HAEMATOLOGICA

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation

(2015) Manuela Moraru et al.   JOURNAL OF IMMUNOLOGY

Antibody-Mediated Response of NKG2CbrightNK Cells against Human Cytomegalovirus

(2015) Marcel Costa-Garcia et al.   JOURNAL OF IMMUNOLOGY

The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine

(2015) Olatz Zenarruzabeitia et al.   JOURNAL OF IMMUNOLOGY

Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility

(2015) Dara M. Strauss-Albee et al.   Science Translational Medicine

‘Emergency exit’ of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation

(2015) Federica Bozzano et al.   Nature Communications

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human

(2015) Qingfeng Chen et al.   Scientific Reports

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing   +T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

(2015) L. Muccio et al.   HAEMATOLOGICA

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells

(2014) Elisa Montaldo et al.   IMMUNITY

Cutting Edge: Priming of NK Cells by IL-18

(2014) J. Chaix et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Infection Promotes Rapid Maturation of NK Cells Expressing Activating Killer Ig-like Receptor in Patients Transplanted with NKG2C-/- Umbilical Cord Blood

(2014) M. Della Chiesa et al.   JOURNAL OF IMMUNOLOGY

Stromal Cells from Human Decidua Exert a Strong Inhibitory Effect on NK Cell Function and Dendritic Cell Differentiation

(2014) Daniele Croxatto et al.   PLoS One

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

(2014) Merlin Luetke-Eversloh et al.   PLoS Pathogens

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

(2014) I. P. da Silva et al.   Cancer Immunology Research

TLR/NCR/KIR: Which One to Use and When?

(2014) Simona Sivori et al.   Frontiers in Immunology

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: A different perspective of the host-pathogen interaction

(2013) Aura Muntasell et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion

(2013) Nicholas J. Patterson et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Priming of NK Cell Anti-Viral Effector Mechanisms by Direct Recognition of Human Cytomegalovirus

(2013) Aura Muntasell et al.   Frontiers in Immunology

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Differentiation of human peripheral blood V 1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

(2011) D. V. Correia et al.   BLOOD

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

(2011) M. Della Chiesa et al.   BLOOD

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

(2011) B. Foley et al.   BLOOD

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

(2011) Nicolas F Delahaye et al.   NATURE MEDICINE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Unifying concepts of MHC-dependent natural killer cell education

(2011) Julie M. Elliott et al.   TRENDS IN IMMUNOLOGY

Natural killer-cell differentiation by myeloid progenitors

(2010) B. Grzywacz et al.   BLOOD

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2

(2010) S. Sivori et al.   BLOOD

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia

(2009) E. Brunetta et al.   BLOOD

NK cell education: not an on-off switch but a tunable rheostat

(2009) Petter Brodin et al.   TRENDS IN IMMUNOLOGY

Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells

(2008) P. Vacca et al.   INTERNATIONAL IMMUNOLOGY

Methylprednisolone induces preferential and rapid differentiation of CD34+ cord blood precursors toward NK cells

(2008) C. Vitale et al.   INTERNATIONAL IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY