Article
Environmental Sciences
Ziga Tkalec, Garry Codling, Jana Klanova, Milena Horvat, Tina Kosjek
Summary: This study developed a method for extracting biomarkers from urine and used a high-resolution mass spectrometer for a more comprehensive understanding of human exposure.
Article
Environmental Sciences
Chih-Wei Chang, Jen-Yi Hsu, Yu-Hsiang Su, Yuan-Chih Chen, Ping-Zu Hsiao, Pao-Chi Liao
Summary: Hair has emerged as a biospecimen for long-term chemical exposome studies, but is not widely adopted compared to blood and urine. In this study, a high-resolution mass spectrometry (HRMS)-based suspect screening strategy was used to characterize the chemical exposome in human hair. 587 suspect features were matched to 246 unique chemical formulas, and 167 chemicals were identified. Hair reflects the accumulation of environmental compounds, and hair analysis may be promising for monitoring long-term exposure to multiple environmental chemicals.
Article
Environmental Sciences
Young-Mi Go, Jaclyn Weinberg, Sami Teeny, Piera M. Cirillo, Nickilou Y. Krigbaum, Grant Singer, ViLinh Tran, Barbara A. Cohn, Dean P. Jones
Summary: Breast cancer, accounting for 12% of all new annual cancer cases worldwide, is the most common cancer globally. An exposome research study using high-resolution mass spectrometry identified suspect environmental chemicals associated with breast cancer and discovered potential mechanistic associations with the disease.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Cesar A. Marasco Junior, Madison E. Edwards, Rafaela S. Lamarca, Tiago J. P. Sobreira, Jeffrey M. Caterino, David S. Hains, Andrew L. Schwaderer, Paulo Clairmont F. de Lima Gomes, Christina R. Ferreira
Summary: Thousands of chemical compounds produced by industry are widely spread in the human environment and new chemicals continue to be introduced. This study proposed a screening workflow to detect exogenous compounds in human urine samples, allowing for the selection and further analysis of these compounds. The results of the screening suggested the presence of five exogenous compounds in the samples.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Oraporn Dumrongwongsiri, Pattanee Winichagoon, Nalinee Chongviriyaphan, Umaporn Suthutvoravut, Veit Grote, Berthold Koletzko
Summary: Maternal nutritional status and mode of delivery are significantly associated with zinc and iron stores at birth, highlighting the importance of ensuring adequate nutrition during preconception and pregnancy to build sufficient nutrient stores for infants.
Article
Environmental Sciences
Ziga Tkalec, Garry Codling, Janja Snoj Tratnik, Darja Mazej, Jana Klanova, Milena Horvat, Tina Kosjek
Summary: This study used high-resolution mass spectrometry to analyze organic contaminants in the urine of children aged 6-9 in Slovenia, identifying numerous harmful biomarkers. Additionally, it tentatively identified compounds not previously monitored in other studies, which could have adverse health effects on children.
ENVIRONMENTAL POLLUTION
(2022)
Article
Medicine, General & Internal
Muna Saleh, Michele Compagno, Sofia Pihl, Helena Strevens, Barbro Persson, Jonas Wettero, Bo Nilsson, Christopher Sjowall
Summary: The complement system plays a crucial role during pregnancy, but excessive activation can lead to pregnancy complications. The clinical value of complement system activation during pregnancy is still unclear. This study analyzed complement proteins in maternal plasma and umbilical cord blood, and found that the reference values were applicable to the majority of samples.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nadja Kupper, Berthold Huppertz
Summary: This article discusses the importance of the placental exposome on maternal health and normal pregnancy development, as well as the role and interaction of placenta-derived extracellular vesicles in this process.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Environmental Sciences
Hesam Movassagh, Yuliya Halchenko, Vanitha Sampath, Unni C. Nygaard, Brian Jackson, David Robbins, Zhigang Li, Kari C. Nadeau, Margaret R. Karagas
Summary: The study found that gestational exposure to mercury concentrations may alter the frequency of cord blood T cells and placental gene expression, potentially leading to immunotoxic effects.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Arash Derakhshan, Elise M. Philips, Akhgar Ghassabian, Susana Santos, Alexandros G. Asimakopoulos, Kurunthachalam Kannan, Andreas Kortenkamp, Vincent W. V. Jaddoe, Leonardo Trasande, Robin P. Peeters, Tim I. M. Korevaar
Summary: Exposure to bisphenols during pregnancy may interfere with maternal thyroid function and affect the thyroid system in offspring. There were associations between BPA and BPS concentrations with maternal thyroid function, with late pregnancy BPA exposure linked to higher TSH in female newborns and higher FT4 during childhood in males.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Meera Shanmuganathan, Meghan Bogert, Zachary Kroezen, Philip Britz-McKibbin, Stephanie A. Atkinson
Summary: This study explores the intake of choline and carnitine during pregnancy and their effects on choline and carnitine metabolites. The findings showed that despite inadequate choline intake, serum-free choline levels were elevated in late pregnancy and enriched in cord blood compared with maternal serum. However, serum carnitine levels declined in late pregnancy. The higher cord:maternal concentrations in choline and carnitine metabolites suggest active uptake in late pregnancy, reflecting the importance of these circulating metabolites in fetal development.
JOURNAL OF NUTRITION
(2023)
Article
Environmental Sciences
Anna O. Lukina, Mandy Fisher, Cheryl Khoury, John Than, Mireille Guay, Jean-Francois Paradis, Tye E. Arbuckle, Melissa Legrand
Summary: Prenatal exposure to total mercury (T-Hg) from both natural and anthropogenic sources can have potential impacts on future neurological and physiological functions. Hair is a useful indicator of chronic T-Hg exposure, and studies have shown a decrease in T-Hg levels in both hair and maternal blood during pregnancy. Low T-Hg levels were found in meconium, and mercury levels in blood and hair were correlated with consumption of large predatory fish.
Article
Endocrinology & Metabolism
Xin He, Margaret Banker, Muraly Puttabyatappa, Vasantha Padmanabhan, Richard J. Auchus
Summary: This study characterizes the levels of 11-oxygenated androgens (11oAs) in normal human pregnancy and neonatal period. The results show that 11 beta-hydroxyandrostenedione (11OHA4) and 11-ketoandrostenedione (11KA4) are the dominant 11oAs in pregnancy and cord blood. The concentration of 11KA4 increases during pregnancy, and in cord blood, it exceeds the concentrations of both 11OHA4 and 11KT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Britton D. Rink, Blair K. Stevens, Mary E. Norton
Summary: Cell-free DNA technology is widely used in screening, diagnosis, and treatment of various diseases. The similarity between placental physiology and tumor development can lead to false-positive results for maternal malignancy in cell-free DNA screening. There is currently no consensus guideline for counseling and evaluation of patients with concerns about malignancy from cell-free DNA testing. Furthermore, laboratories differ in reporting policies and strategies. It is important for ordering practitioners to understand the policies of their chosen laboratory in order to provide appropriate genetic counseling. Pretest counseling should explain the potential for unexpected or nonreportable findings, while posttest counseling should include a discussion of possible fetal or maternal diagnoses, including malignancy.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Qianyu Chen, Yayun Zhang, Langjie Ye, Shuai Gong, Hong Sun, Guanyong Su
Summary: The study established a strategy combining lipidomic analysis with high-throughput suspect contaminant screening to efficiently identify active xenobiotics in humans. By analyzing serum samples from Wuxi city, China, the study found correlations between suspect contaminants and lipids, identifying 23 active contaminants including PFOA, PFOS, and DEP. The study also observed significant changes in levels of triglyceride, lysophosphocholine, and sphingomyelin as peak areas of xenobiotics increase, providing novel knowledge on potential alterations of lipid metabolism in humans following exposure to xenobiotics.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Dimitri Panagopoulos, Annika Jahnke, Amelie Kierkegaard, Matthew MacLeod
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2015)
Article
Thermodynamics
Dimitri Panagopoulos, Amelie Kierkegaard, Annika Jahnke, Matthew MacLeod
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2016)
Article
Engineering, Environmental
Dimitri Panagopoulos, Annika Jahnke, Amelie Kierkegaard, Matthew MacLeod
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2017)
Article
Chemistry, Analytical
Dimitri Panagopoulos, Matthew MacLeod
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2018)
Article
Engineering, Environmental
Dimitri Panagopoulos Abrahamsson, Aolin Wang, Ting Jiang, Miaomiao Wang, Adi Siddharth, Rachel Morello-Frosch, June-Soo Park, Marina Sirota, Tracey J. Woodruff
Summary: This study utilized mass spectrometry to analyze matched maternal and cord blood samples, revealing significant associations between exogenous compounds and endogenous metabolites, indicating potential interactions between them.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Dimitri Abrahamsson, Adi Siddharth, Thomas M. Young, Marina Sirota, June-Soo Park, Jonathan W. Martin, Tracey J. Woodruff
Summary: This study aims to develop a computational pipeline that integrates HRMS data and physicochemical properties to propose molecular structures for detected chemical features. The use of physicochemical fingerprints can assist in compound identification and increase the number of identified compounds.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Environmental Sciences
Dimitri Abrahamsson, Adi Siddharth, Joshua F. Robinson, Anatoly Soshilov, Sarah Elmore, Vincent Cogliano, Carla Ng, Elaine Khan, Randolph Ashton, Weihsueh A. Chiu, Jennifer Fung, Lauren Zeise, Tracey J. Woodruff
Summary: This study developed a machine learning model to describe the transplacental transfer of chemicals and made predictions for 7982 PFAS compounds. The results suggested that certain compounds are more likely to enter fetal blood, which has significant implications for public health.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Dana E. Goin, Dimitri Abrahamsson, Miaomiao Wang, Ting Jiang, June -Soo Park, Marina Sirota, Rachel Morello-Frosch, Erin DeMicco, Marya G. Zlatnik, Tracey J. Woodruff
Summary: This study identified differences in chemical exposures between pregnant women giving birth in two different types of hospitals in San Francisco, likely due to the social conditions faced by the populations served.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Analytical
Dimitri Panagopoulos Abrahamsson, Nicholas Alexander Warner, Liisa Jantunen, Annika Jahnke, Fiona Wong, Matthew MacLeod
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2020)