Article
Environmental Sciences
Jorn Rittweger, Lorenza Gilardi, Maxana Baltruweit, Simon Dally, Thilo Erbertseder, Uwe Mittag, Muhammad Naeem, Matthias Schmid, Marie-Therese Schmitz, Sabine Wuest, Stefan Dech, Jens Jordan, Tobias Antoni, Michael Bittner
Summary: This study investigated the medium-term residential exposure to meteorological and pollutant factors in rural and urban areas in a temperate climate, and found that fine particulate matter, air temperature, precipitation, and NO2 significantly influenced the incidence of influenza.
ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
L. D. Gruer, G. Cezard, L. A. Wallace, S. J. Hutchinson, A. F. Douglas, D. Buchanan, S. Katikireddi, A. D. Millard, D. J. Goldberg, A. Sheikh, R. S. Bhopal
Summary: The research found ethnic differences in overall infection rates and many infection categories, suggesting multiple causative pathways. The study recommends census linkage as a powerful method for studying the disproportionate impact of COVID-19.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Stephanie A. Brennhofer, James A. Platts-Mills, Joseph A. Lewnard, Jie Liu, Eric R. Houpt, Elizabeth T. Rogawski McQuade
Summary: This study analyzed diarrhea cases in children aged 0-2 years in low-resource settings and found that Shigella and rotavirus were the leading causes of antibiotic treatment. These pathogens were more likely to be treated with antibiotics compared to other causes of diarrhea.
Article
Medicine, General & Internal
Cheru Tesema Leshargie, Daniel Demant, Sahai Burrowes, Jane Frawley
Summary: This study aimed to assess the incidence and predictors of mortality in adolescents receiving ART in Ethiopia's Amhara Region. The study found that factors such as lack of formal education, widowed parents, lack of social support, opportunistic infections, low hemoglobin levels, bedridden functional status, stage IV clinical staging, non-disclosing HIV status, and CD4 count 200-350 cells/mm³ were associated with higher mortality risk. Not receiving cotrimoxazole preventive therapy and poor adherence to ART were also associated with higher mortality risk. Changed treatment regimens were associated with lower mortality.
Article
Environmental Sciences
Anthony J. F. Reardon, Morteza Hajihosseini, Irina Dinu, Catherine J. Field, David W. Kinniburgh, Amy M. MacDonald, Deborah Dewey, Gillian England-Mason, Jonathan W. Martin, The APrON APrON Study
Summary: This study examined the association between prenatal exposure to PFAAs and child neurodevelopment. The findings suggest that certain PFAAs are associated with lower cognitive and language abilities. Specifically, total PFOS and its isomers were found to be related to lower language abilities. In conclusion, maternal exposure to PFAAs during pregnancy has adverse effects on child neurodevelopment.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Agne Ulyte, Thomas Radtke, Irene Alma Abela, Sarah R. Haile, Jacob Blankenberger, Ruedi Jung, Celine Capelli, Christoph Berger, Anja Frei, Michael Huber, Merle Schanz, Magdalena Schwarzmueller, Alexandra Trkola, Jan Fehr, Milo Alan Puhan, Susi Kriemler
Summary: The study found that by the end of June 2020, the seroprevalence of SARS-CoV-2 in children was low in the canton of Zurich, Switzerland, with variations across different grades and schools. The seroprevalence in children was similar to that in adults, and the ratio of diagnosed cases to seropositive cases was very low in children.
Article
Medicine, General & Internal
Lise Gehrt, Ida Laake, Helene Englund, Heta Nieminen, Berit Feiring, Mika Lahdenkari, Arto A. Palmu, Lill Trogstad, Christine Stabell Benn, Signe Sorup
Summary: The NONSEnse project aims to investigate the non-specific effects of vaccines and immunisation programmes on the overall health of children by using nationwide registers in Denmark, Finland, Norway, and Sweden. The cohort includes 9,072,420 children born between 1990 and 2017/2018. Data collection and harmonisation has been completed, and future studies on the effects of childhood vaccinations are planned. Importance rating: 9/10
Article
Medicine, General & Internal
Zeyang Yu, Tian-Tian Zhang, Xiaomeng Wang, Qinxue Chang, Huijie Huang, Honglu Zhang, Desheng Song, Maohe Yu, Jie Yang, Yuanyuan Liu, Changping Li, Zhuang Cui, Jun Ma
Summary: This study aimed to understand the behavior pattern changes of Chinese men who have sex with men (MSM) and their association with HIV risk. The results showed that behavior type changes were correlated with HIV infection risk, highlighting the importance of timely behavior change for individuals at high risk.
Article
Pediatrics
Damien Foo, Mohinder Sarna, Gavin Pereira, Hannah C. Moore, Annette K. Regan
Summary: This retrospective cohort study examined the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and the risk of a diagnosis of a neurodevelopmental disorder in early childhood. The results showed that there was no increased risk of neurodevelopmental disorders following in utero exposure to seasonal IIV. However, there was some evidence suggesting that exposure during the first trimester may reduce the risk of seizure disorders, and exposure in preterm children may reduce the risk of sleep disorders.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Surgery
Ilkka Helantera, Mika Gissler, Ruska Rimhanen-Finne, Niina Ikonen, Mari Kanerva, Marko Lempinen, Patrik Finne
Summary: Compared to the general population, kidney transplant recipients have a significantly higher risk of laboratory-confirmed influenza, with incidence increased fivefold, and more than fourfold risk of hospitalization due to influenza. The impact of influenza on transplant recipients is substantial.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Environmental Sciences
Sheng-Han Lee, Wei-Chen Tseng, Zhi-Yi Du, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Guang-Wen Lien, Hao-Jan Liang, Hui-Ju Wen, Yue-Leon Guo, Pau-Chung Chen, Ching-Yu Lin
Summary: This study evaluated the impact of PFASs exposure on lipid changes in children, finding that children exposed to different levels of specific PFASs exhibited different lipid patterns, potentially related to hepatic lipid metabolism, metabolic disorders, and PFASs-membrane interactions.
ENVIRONMENTAL POLLUTION
(2021)
Article
Public, Environmental & Occupational Health
Joanne Lacy, Anna Mensah, Ruth Simmons, Nick Andrews, M. Ruby Siddiqui, Antoaneta Bukasa, Shennae O'Boyle, Helen Campbell, Kevin Brown
Summary: This study suggests that prior SARS-CoV-2 infection provides protection against reinfection, with a protective effect ranging from 78% to 82%. Among individuals who experienced reinfection, the symptoms were milder and the risk of death was lower in the second episode.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Chemistry, Organic
Guizhao Wang, Nianhua Yu, Ying Wen, Faqiang Leng
Summary: In this study, a one-pot tandem perfluoroalkylation-defluorination reaction of indole, perfluoroalkyl iodide, and water in the presence of Na2S2O4 was reported. Various indole derivatives were efficiently synthesized with good yields under mild reaction conditions. The reaction is believed to proceed through perfluoroalkylation and defluorination hydrolysis pathway. This study provides an alternative approach for defluorination functionalization.
Article
Public, Environmental & Occupational Health
Thomas Ward, Alex Glaser, Christopher E. Overton, Bob Carpenter, Nick Gent, Anna C. Seale
Summary: New SARS-CoV-2 variants pose a major risk to public health globally, with the potential for phenotypic changes, increased pathogenicity, enhanced transmissibility, and the ability to evade vaccines. Understanding the characteristics and timing of these new variants in terms of infection, hospitalization, and death is crucial for informing public health responses. This study analyzed data on contact tracing, testing, and hospitalization in England to investigate the time periods associated with different variants. The findings revealed variations in the incubation period, time from infection to hospitalization, and time from hospitalization to death among different variants. Shorter incubation periods were associated with a higher risk of fatality, while shorter hospitalization and death times were linked to variant severity. These findings have important implications for assessing the risk of new variants and their potential impact on population health.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Environmental Sciences
Catherine M. Bulka, Vennela Avula, Rebecca C. Fry
Summary: Research suggests that exposures to per- and polyfluoroalkyl substances (PFAS) may systematically increase susceptibility to persistent infections and higher pathogen burdens, particularly among adolescents. The study found significant associations between individual PFAS and pathogen burdens, with the most pronounced effects seen in adolescents. Furthermore, PFAS mixtures as a whole were also associated with higher pathogen burdens, indicating a potential link between PFAS exposure and increased susceptibility to persistent infections.
ENVIRONMENTAL POLLUTION
(2021)
Article
Public, Environmental & Occupational Health
Thomas Clausen, Jeppe Karl Sorensen, Louise Dalsager, Iben Louise Karlsen, Jesper Kristiansen
Summary: This study assessed the interactions between different combinations of demands (quantitative demands, emotional demands, unclear and contradictory demands, and violence/threats of violence) and their prospective association with the risk of long-term sickness absence (LTSA). The results showed that participants who reported high quantitative demands combined with violence/threats of violence or unclear and contradictory demands had a higher risk of LTSA than expected, indicating superadditivity.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Correction
Environmental Sciences
Annelise Blomberg, Jann Mortensen, Pal Weihe, Philippe Grandjean
ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Iben Have Beck, Niels Bilenberg, Soeren Moeller, Flemming Nielsen, Philippe Grandjean, Frederik Damsgaard Hojsager, Thorhallur Ingi Halldorsson, Christel Nielsen, Tina Kold Jensen
Summary: The study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) may affect intelligence quotient (IQ), especially higher concentrations of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were associated with lower IQ scores.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Steffen Husby, Joseph Murrary
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Environmental Sciences
Iben Have Beck, Niels Bilenberg, Helle Raun Andersen, Fabio Trecca, Dorthe Bleses, Tina Kold Jensen
Summary: This study investigated the association between prenatal and early postnatal PFAS exposure and delayed language development in Danish children aged 18 to 36 months, and found no significant association between PFAS exposure and language development. The study recommends assessing child serum PFAS at an older age, considering the potential positive effect of breastfeeding on neurodevelopment.
ENVIRONMENTAL HEALTH
(2023)
Article
Peripheral Vascular Disease
Hajir Al-Jorani, Richard Christian Jensen, Mikaela T. E. Jonasson, Anna Birukov, Anne Vibeke Schmedes, Henrik Thybo Christesen, Anja F. Dreyer, Tina K. Jensen, Dorte Glintborg, Boye L. Jensen, Marianne S. Andersen
Summary: This study investigated the association between maternal cortisol levels in the third trimester of pregnancy and offspring blood pressure (OBP). The results showed negative associations between maternal cortisol levels and OBP, specifically in boys. This suggests that maternal cortisol is not a risk factor for higher blood pressure in offspring up to the age of 5.
Article
Public, Environmental & Occupational Health
Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Tiina Santonen., Petra Apel., Paula. Alvito, Elena. Anastasi, Helle Raun Andersen, Anna-Maria Andersson, Lenka Andryskova, Jean-Philippe Antignacj, Brice Appenzeller, Fabio Barbone, Zohar Barnett-Itzhaki, Robert Barouki, Tamar Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Canas-Portilla, Adrian Covaci, Zsofia Csako, Elly Den Hond, Darina Dvorakova, Lucia Fabelova, Tony Fletcherx, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Goen, Thorhallur Halldorsson, Line S. Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Natasa Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klanova, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuki, Matthieu Meslin, Hans Molar, Parisa Montazeri, Aline Murawski, Sonia Namorado, Lars Niemann, Stefanie Nabler, Baltazar Nunes, Kristin Olafsdottir, Lubica Palkovicova Murinova, Nafsika Papaioannou, Susana Pedraza-Diaz, Pavel Pileri, Veronika Plichta, Michael Poteser, Nicole Probst-Hensch, Loic Rambaud, Elke Rauscher-Gabernig, Katarina Rausova, Sylvie Remy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rather, Denis Sarigiannis, Maria J. Silva, Zdenka Slejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamas Szigeti, Jose V. Tarazona, Cathrine Thomsen, Ziga Tkalec, Hanna Tolonen, Tomas Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wasowicz, Till Weber, Sona Wimmerova, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonari, Holger Koch, Marike Kolossa-Gehring, Marta Esteban Lopez, Argelia Castano, Lorraine Stewartx, Ovnair Sepaix, Greet Schoeters
Summary: As part of the European Human Biomonitoring Initiative, a human biomonitoring survey was conducted in 23 countries to produce comparable data for the EU. The survey utilized existing HBM capacity in Europe and aligned national or regional studies under the HBM4EU program. The survey included over 10,000 participants from different age groups and measured various biomarkers to assess exposure levels to different chemicals. The data obtained can be used as a reference for global comparison, evaluate the effectiveness of the European Commission's chemical strategy, and guide policy-making.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nina Vogel, Phillipp Schmidt, Rosa Lange, Antje Gerofke, Amrit K. Sakhi, Line S. Haug, Tina Kold Jensen, Hanne Frederiksen, Tamas Szigeti, Zsofia Csako, Lubica Palkovicova Murinova, Miroslava Sidlovska, Beata Janasik, Wojciech Wasowicz, Janja Snoj Tratnik, Darja Mazej, Catherine Gabriel, Spyros Karakitsios, Fabio Barbonem, Valentina Rosolen, Loic Rambaud, Margaux Riou, Aline Murawski, Daan Leseman, Gudrun Koppen, Adrian Covaci, Sanna Lignell, Anna Karin Lindroos, Martin Zvonar, Lenka Andryskova, Lucia Fabelova, Denisa Richterova, Milena Horvatj, Tina Kosjekj, Denis Sarigiannis, Marios Maroulis, Susana Pedraza-Diaz, Ana Canas, Veerle J. Verheyen, Michiel Bastiaensen, Liese Gilles, Greet Schoeters, Marta Esteban-Lopez, Argelia Castano, Eva Govarts, Holger M. Kochx, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers for PVC and are associated with adverse effects on the reproductive system. The HBM4EU Aligned Studies have investigated the exposure to ten phthalates and the substitute chemical DINCH in European children and adolescents. The study provides detailed data on exposure levels and differences across European regions, as well as comparisons to biomonitoring guidance values.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Hanne Mumm, Anja Fenger Dreyer, Dorthe Bleses, Dorte Glintborg, Tina Kold Jensen, Henriette Boye, Fabio Trecca, Marianne Skovsager Andersen
Summary: This prospective observational study aimed to evaluate the association between maternal third trimester cortisol and early longitudinal offspring language development, and to test whether there were sex differences in the association. The results showed that higher maternal cortisol levels in the third trimester were positively associated with early language development in children, with boys showing effects on productive vocabulary and girls showing effects on receptive vocabulary.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Pediatrics
Philippe Grandjean, Yu-Hsuan Shih, Louise Helskov Jorgensen, Flemming Nielsen, Pal Weihe, Esben Budtz-Jorgensen
Summary: A study found that early exposure to perfluoroalkyl substances (PFASs) was associated with lower resistin concentrations at the age of 9, suggesting that infancy may be a vulnerable time window for metabolic programming affected by PFAS exposure.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Frederik Damsgaard Hojsager, Annika Sigvaldsen, Marianne Skovsager Andersen, Anders Juul, Flemming Nielsen, Soren Moller, Henrik Boye Thybo Christesen, Anders Grontved, Philippe Grandjean, Tina Kold Jensen
Summary: This study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) is associated with lower bone mineral density (BMD) at age 7. The association is stronger for exposure at 18 months than prenatal exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Environmental Sciences
Sidsel Dan Hull, Laura Deen, Kajsa Ugelvig Petersen, Tina Kold Jensen, Paula Hammer, Regitze Solling Wils, Hannah N. o rtoft Frankel, Sisse Rye Ostrowski, Sandra Sogaard Tottenberg
Summary: The study aimed to investigate the temporal trends of PFAS concentrations in the Danish population. The results showed a significant decline in blood concentrations of PFOS and PFOA from the late 1990s until 2021, reflecting a decrease in the use of these substances. The time trends for other PFAS were less evident but also displayed a tendency towards a decrease.
ENVIRONMENTAL RESEARCH
(2023)