Review
Chemistry, Multidisciplinary
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammad Ali Abdullah Almoyad, Shadma Wahab, Waleed H. Almalki, Prashant Kesharwani
Summary: Nanosponges, with their unique sponge-like structure, offer a promising solution for drug delivery in cancer therapy. By utilizing their interconnected voids and mesh-like network, nanosponges enable efficient drug loading and controlled release, overcoming the limitations of conventional methods. They show potential in both cancer treatment and diagnosis, and are considered versatile carrier systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Oncology
Akhil Srivastava, Shipra Rathore, Anupama Munshi, Rajagopal Ramesh
Summary: Exosomes, as a natural form of cell communication, have potential applications as drug delivery vehicles and in cancer treatment. However, challenges such as sourcing and scaling up production need to be addressed for broader use.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Nour K. Younis, Rami Roumieh, Emmanuel P. Bassil, Joseph A. Ghoubaira, Firas Kobeissy, Ali H. Eid
Summary: This article introduces the role and potential of nanoparticles in diagnosing and treating colorectal cancer. Nanomedicine, as a new treatment modality, has the ability to overcome the limitations of traditional treatments and has been widely studied in clinical research. The article describes the therapeutic effects of several types of nanoparticles and their significance in targeted drug delivery, while also emphasizing the importance of nanomedicine in managing colorectal cancer and other diseases.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Jiang Zhao, Chi Zhang, Weihao Wang, Chen Li, Xupeng Mu, Kebang Hu
Summary: Nanotechnology, with its potential to combine treatment with diagnostic imaging tools, is emerging as a promising therapy for prostate cancer. Nanoparticles can accumulate at the site of pathology through passive and active targeting techniques, reducing side effects on healthy tissues. Additionally, nanotechnology can synergize with other treatment methods to enhance efficacy and reduce resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Yu Qi, Xu Yan, Tian Xia, Sijin Liu
Summary: Nano-based cancer theranostics face challenges in achieving expected efficacy due to low nanoparticle accumulation in tumors. Cell-aided strategies, particularly involving macrophages, show promise in improving the therapeutic efficacy of nanomedicines. Further research is needed to understand the interactions between macrophages, nanomedicines, and tumor cells for enhancing anti-cancer immunity in the tumor microenvironment.
MATERIALS & DESIGN
(2021)
Review
Oncology
Fakhara Sabir, Mahira Zeeshan, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Magali Cucchiarini, Sadanand Pandey
Summary: DNA-based smart nano-carriers can deliver drugs to tumor cells efficiently, enhancing treatment efficacy and minimizing damage to healthy cells. However, before clinical translation, challenges such as understanding in vivo parameters and drug delivery mechanisms must be addressed.
Article
Pharmacology & Pharmacy
Hao Cai, Yufan Xiang, Yujun Zeng, Zhiqian Li, Xiuli Zheng, Qiang Luo, Hongyan Zhu, Qiyong Gong, Zhongwei Gu, Yanhui Liu, Hu Zhang, Kui Luo
Summary: Multi-modal therapeutics using polymeric carriers for simultaneous diagnosis and treatment of cancer have been developed. A theranostic nanomedicine, branched glycopolymer-PTX-DOTA-Gd, showed extended circulation time, enhanced tumor accumulation, and excellent biocompatibility with reduced gadolinium ion retention. This branched polymeric prodrug-based nanomedicine has great potential for safe and effective cancer diagnosis and treatment, achieving enhanced imaging contrast and high antitumor efficacy.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Medicine, Research & Experimental
Lu Tang, Jing Li, Ting Pan, Yue Yin, Yijun Mei, Qiaqia Xiao, Ruotong Wang, Ziwei Yan, Wei Wang
Summary: Despite advancements in medicine, cancer remains a leading cause of death worldwide. Traditional treatment strategies often come with severe adverse effects and limited efficacy. Nanotechnology, particularly carbon nanomaterials, has shown great promise in cancer therapy due to their unique properties. Developing carbon-based nanoplatforms is critical for improving cancer theranostics. This review introduces the use of graphene, graphdiyne, fullerene, carbon nanotubes, and carbon quantum dots in cancer treatment, as well as their diagnostic potential.
Review
Chemistry, Multidisciplinary
Jinping Wang, Beilu Zhang, Jingyu Sun, Wei Hu, Hongjun Wang
Summary: Porous nanomaterials with high surface area, tunable porosity, and large mesopores have attracted attention in cancer therapy and imaging. Researchers have been working on fabricating various porous nanomaterials and exploring their potentials in oncology applications.
Review
Materials Science, Biomaterials
Shikha Gulati, Akangkha Choudhury, Gauravya Mohan, Riya Katiyar, M. P. Mohammed Abaan Kurikkal, Sanjay Kumar, Rajender S. Varma
Summary: Metal-organic frameworks (MOFs) are multifunctional organometallic compounds that combine metal ions with various organic linkers. Due to their exceptional qualities, such as wide surface area, high porosity, biocompatibility, and non-toxicity, MOFs have gained widespread attention in medicine. They have been recognized as promising candidates for biosensing, molecular imaging, drug delivery, and enhanced cancer therapies. This review highlights the key attributes of MOFs in cancer research, emphasizing their structural and synthetic aspects, diagnostic and therapeutic features, as well as their performance and significance in modern therapeutic methods and synergistic theranostic strategies including biocompatibility.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Khushboo Pathania, Sangeeta P. Sah, Deepak B. Salunke, Manish Jain, Ashok Kumar Yadav, Vikramaditya G. Yadav, Sandip V. Pawar
Summary: Polymeric magnetic nanoparticles based on lignin have been developed for targeted delivery of methotrexate, showing higher efficacy in cancer diagnosis and treatment. The synthesized nanoparticles exhibit magnetic and smooth polyhedral traits with a dimension of 110-130 nm. The drug-loaded nanoparticles have high cytotoxicity in breast cancer and macrophage cell lines and exhibit sustained release of methotrexate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Lu Liu, Hongjun Li, Jinqiang Wang, Jinchao Zhang, Xing-Jie Liang, Weisheng Guo, Zhen Gu
Summary: Macrophages play a dual role in cancer development and are being explored as targets and tools for cancer theranostics. This article provides an overview of the mixed roles of macrophages in cancer pathogenesis and highlights the latest progress in macrophage-based cancer theranostic strategies, focusing on targeting tumor-associated macrophages and engineering adoptive macrophages to enhance immunosuppression and improve therapeutic efficacy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Wei Liu, Xin Li, Ting Wang, Fei Xiong, Changrui Sun, Xikuang Yao, Wei Huang
Summary: Platinum (Pt) drugs are widely used in cancer therapy, but their efficacy is compromised by side effects and drug resistance. Precise delivery and release of Pt drugs have become important with the development of immunotherapy and imaging-guided therapy. Targeted delivery of Pt drugs increases accumulation at tumor sites and enhances antitumor efficacy. Combining Pt drugs with other theranostic agents in nanosystems achieves synergistic therapy and real-time monitoring.
Article
Chemistry, Medicinal
Matan Soll, Vinay K. Sharma, Sally Khoury, Yehuda G. Assaraf, Zeev Gross
Summary: The nanoparticle-based system of 3-Ga NPs demonstrates remarkable tumor growth inhibition against human metastatic castration-resistant prostate cancer and shows potential as a sonodynamic agent for the treatment of pancreatic cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Khalid Saad Alharbi, Sami Alzarea, Mohd Yasir, Muhammad Afzal, Sultan Alshehri, Abdullah S. Alanazi
Summary: The study prepared LT-loaded CH-PLGA nanoparticles and optimized and evaluated their properties. The results showed that CH-PLGA-LT-NPs exhibited sustained drug release and significant effects in reducing blood glucose level and improving biochemical parameters.
JOURNAL OF CLUSTER SCIENCE
(2023)
Review
Chemistry, Organic
Saad Alghamdi, Mohammad Asif
Summary: The pyridazinone derivatives are highly versatile and easily synthesized, making them an attractive area of research for novel bioactive compounds. Substituted pyridazines have demonstrated a wide range of pharmacological activities, including analgesic, anti-inflammatory, antibacterial, antifungal, anticonvulsant, antidepressant, antianxiety, antitubercular, anti-malarial, anticancer, anti-HIV, platelet inhibitory, hypotensive, and cardiotonic effects. It can be concluded that pyridazinone derivatives hold great promise and future research is needed to fully understand their potential.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Abul Barkat, Mahfoozur Rahman, Khalid S. Alharbi, Waleed M. Altowayan, Majed Alrobaian, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Fahad Saad Alhodieb, Waleed H. Almalki, Hani Choudhry, Tanuja Singh, Sarwar Beg
Summary: The polymeric nanoparticles loaded with tamoxifen (TF) and ganoderic acid A (GA-A) showed promising in vitro and in vivo efficacy for treating breast cancer. The optimized formulation exhibited small particle size, high drug entrapment efficiency, and sustained drug release. It significantly reduced cell viability and tumor incidence in the DMBA-induced rat model, and also normalized various hematological and biochemical parameters.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Arafa Musa, Saleh K. K. Ihmaid, David L. L. Hughes, Musa A. A. Said, Hamada S. S. Abulkhair, Ahmed H. H. El-Ghorab, Mohamed A. A. Abdelgawad, Khaled Shalaby, Mohamed E. E. Shaker, Khalid Saad Alharbi, Nasser Hadal Alotaibi, Deborah L. L. Kays, Laurence J. J. Taylor, Della Grace Thomas Parambi, Sami I. I. Alzarea, Ahmed A. A. Al-Karmalawy, Hany E. A. Ahmed, Ahmed M. M. El-Agrody
Summary: The inadequate treatment options for breast cancer are due to the lack of targeted medications, leading to the recurrence of metastatic disorders. Overexpression of EGFR-TK and CDK-9 in breast cancer patients is associated with worse overall survival. We synthesized two series of suggested anticancer molecules and characterized them using various methods. Unexpectedly, our attempt to obtain pyranopyrazole-gold complexes yielded benzylidene-2,4-dihydro-3H-pyrazol-3-one instead. The synthesized compounds showed variable cytotoxicity and effectively inhibited EGFR-TK and CDK-9.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Neurosciences
Shmmon Ahmad, Abdul Hafeez
Summary: This study investigates the use of nanotechnological approach to enhance the bioavailability and permeability of curcumin for the treatment of Alzheimer's disease. The CUR-PIP-loaded SNEDDS formulation shows promising therapeutic effects and could be a potential carrier for the oral delivery of curcumin to the brain.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Chemistry, Physical
Arpita Roy, Srijal Kunwar, Utsav Bhusal, Saad Alghamdi, Mazen Almehmadi, Hayaa M. Alhuthali, Mamdouh Allahyani, Md. Jamal Hossain, Md. Abir Hasan, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina
Summary: Nanoparticles less than 100 nm in size have attracted considerable interest in various fields due to their unique physical and chemical characteristics. Trimetallic nanoparticles have shown superior catalytic, biomedical, antimicrobial, active food packaging, and sensing applications compared to monometallic or bimetallic nanoparticles. However, the chemical and physical methods currently used for synthesizing these nanoparticles are expensive and environmentally toxic. This review provides an overview of the synthesis of trimetallic nanoparticles using biological agents and explores their applications in areas such as anticancer, antimicrobial activity, drug delivery, and catalytic activity.
Review
Oncology
Abdulrahman Theyab, Khalaf F. Alsharif, Khalid J. Alzahrani, Atif Abdulwahab A. Oyouni, Yousef MohammedRabaa Hawsawi, Mohammad Algahtani, Saad Alghamdi, Amal F. Alshammary
Summary: In the past 20 years, G-CSFs have become the main treatment option for neutropenia patients. Current G-CSFs require daily injections, which are inconvenient and costly. Development of long-acting G-CSFs with improved efficacy has been possible due to increased understanding of their structure, expression, and clearance mechanism. Various conjugation techniques, such as PEGylation and glycosylation, have successfully increased the half-lives of G-CSFs. The importance of this review lies in highlighting different strategies and techniques used to increase the half-life of biotherapeutic G-CSFs and their benefits and limitations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Muhammad Afzal, Khalid Saad Alharbi, Sami I. Alzarea, Najiah M. Alyamani, Imran Kazmi, Emine Gueven
Summary: Through the study of differentially expressed genes (DEGs) in human cortical neurons using non-negative matrix factorization (NMF), shared genes and relationships between Alzheimer's Disease (AD) and Type 2 diabetes (T2D) have been discovered, providing new directions for the treatment of these diseases.
Article
Immunology
Banan Atwah, Mohammad Shahid Iqbal, Saeed Kabrah, Ahmed Kabrah, Saad Alghamdi, Aisha Tabassum, Mohammed A. Baghdadi, Hissah Alzahrani
Summary: This study conducted in Saudi Arabia found that patients with diabetes are more likely to have symptoms and abnormal laboratory findings associated with COVID-19 disease compared to non-diabetic patients.
Article
Food Science & Technology
Nadeem Sayyed, Abdul Hafeez, Fahad A. A. Al-Abbasi, Asma B. Omer, Shareefa A. A. AlGhamdi, Amira M. M. Alghamdi, Rayan A. A. Sheikh, Imran Kazmi
Summary: Erucic acid improved memory impairment induced by LPS and reduced cognitive impairment. It showed significant improvement in behavioral tests and also lowered acetylcholine esterase activity, proinflammatory markers, and oxidative stress, while restoring endogenous antioxidant levels.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Saad Alghamdi, Hanadi M. Baeissa, Mohammad Azhar Kamal, Misbahuddin M. Rafeeq, Abdullah Al Zahrani, Ali Ahmed Maslum, Israa J. Hakeem, Reem S. Alazragi, Qamre Alam
Summary: Cervical cancer is a common and deadly disease in women worldwide. This study screened the FDA library and identified Sodium Danshensu as a potential multitargeted drug against cervical cancer. The compound showed strong binding affinity and stable complex formation with target proteins, indicating its potential as an effective therapeutic agent.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Saad Alghamdi, Krisha Khandelwal, Soumya Pandit, Arpita Roy, Subhasree Ray, Ahad Amer Alsaiari, Abdulelah Aljuaid, Mazen Almehmadi, Mamdouh Allahyani, Rohit Sharma, Jigisha Anand, Ahmad Adnan Alshareef
Summary: Chemical signal molecules are used by bacteria to communicate and coordinate group behavior. Quorum Sensing (QS) is the process that enables bacterial populations to interact and coordinate their actions. Research has been conducted on inhibiting QS to minimize its negative effects. Quorum quenching (QQ) disrupts microbial communication by breaking down the autoinducer component, preventing its formation, or blocking its reception with inhibitor compounds. Various techniques, such as colorimetry and chromatography-mass spectroscopy, can be used to measure QS/QQ molecules. This article elaborates on the mechanisms of QS and QQ, their application in preventing biofilm formation, and the study of nanoparticle in QQ.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Physical
Yogeshwar Baste, Vikram Jadhav, Arpita Roy, Saad Alghamdi, Mohamed Abbas, Jari S. Algethami, Mazen Almehmadi, Mamdouh Allahyani, Devvret Verma, Krishna Kumar Yadav, Byong-Hun Jeon, Hyun-Kyung Park
Summary: The synthesis of silver-incorporated copper oxide nanomaterials (Ag@CuO NMs) using a polyol-mediated refluxing method is discussed in this study. The photocatalytic activity of these nanomaterials, specifically their ability to degrade methylene blue (MB) dye, is investigated. Results show that the NMs with 5% weight of silver exhibited the highest degradation activity against MB dye, indicating their potential for wastewater purification.
Article
Medicine, General & Internal
Sarah Alsobaie, Arwa A. Alageel, Tahira Ishfaq, Imran Ali Khan, Khalid Khalaf Alharbi
Summary: This study investigated the association between the rs8192675 SNP and women with polycystic ovary syndrome (PCOS) in Saudi Arabia, finding a strong association between the SNP and PCOS women who developed type 2 diabetes mellitus (T2DM). This suggests that this genetic variant may be an important factor in the development of PCOS and T2DM. The findings of this study provide valuable insights into the relationship between PCOS and diabetes.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
