Progress in Defining the Genetic Contribution to Type 2 Diabetes in Individuals of East Asian Ancestry

Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

(2020) Aurelian Bidulescu et al.   BMC Endocrine Disorders

Identification of type 2 diabetes loci in 433,540 East Asian individuals

(2020) Cassandra N. Spracklen et al.   NATURE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

(2020) Marijana Vujkovic et al.   NATURE GENETICS

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

(2020) Ana Viñuela et al.   Nature Communications

The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits

(2019) Sanghoon Moon et al.   Scientific Reports

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

(2019) Ken Suzuki et al.   NATURE GENETICS

Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

(2019) Iona Y Millwood et al.   LANCET

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

(2019) Jason Flannick et al.   NATURE

SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression

(2018) John Biddlestone et al.   BIOCHEMICAL JOURNAL

Nonsynonymous Variants inPAX4andGLP1Rare Associated with Type 2 Diabetes in an East Asian Population

(2018) Soo Heon Kwak et al.   DIABETES

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

(2018) Eric R. Gamazon et al.   NATURE GENETICS

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

(2018) Yukinori Okada et al.   Nature Communications

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

(2018) Cassandra N. Spracklen et al.   PLoS Genetics

Shared genetic risk contributes to type 1 and type 2 diabetes etiology

(2018) Anthony Aylward et al.   HUMAN MOLECULAR GENETICS

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis

(2017) Kazuyoshi Ishigaki et al.   NATURE GENETICS

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

(2017) Wei Zhao et al.   NATURE GENETICS

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

(2017) Arushi Varshney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

(2017) Fatou K. Ndiaye et al.   Molecular Metabolism

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals

(2016) Chloe Y. Y. Cheung et al.   DIABETOLOGIA

The role of leptin in diabetes: metabolic effects

(2016) Thomas H. Meek et al.   DIABETOLOGIA

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Type 2 diabetes: genetic data sharing to advance complex disease research

(2016) Jason Flannick et al.   NATURE REVIEWS GENETICS

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

(2016) Minako Imamura et al.   Nature Communications

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

(2016) Laura J. Scott et al.   Nature Communications

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Modulation of the Association between the PEPD Variant and the Risk of Type 2 Diabetes by n-3 Fatty Acids in Chinese Hans

(2015) Ju-Sheng Zheng et al.   Journal of Nutrigenetics and Nutrigenomics

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

(2015) Jennifer Wessel et al.   Nature Communications

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

(2015) Anubha Mahajan et al.   PLoS Genetics

Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript

(2015) Marta Puig et al.   PLoS Genetics

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

BMI Cut Points to Identify At-Risk Asian Americans for Type 2 Diabetes Screening: Table 1

(2014) William C. Hsu et al.   DIABETES CARE

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

(2014) Wanqing Wen et al.   HUMAN MOLECULAR GENETICS

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

(2013) Ronald C.W. Ma et al.   Annals of the New York Academy of Sciences

Genome-wide association study identifies three novel loci for type 2 diabetes

(2013) Kazuo Hara et al.   HUMAN MOLECULAR GENETICS

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

(2013)   NATURE

Complex Disease Interventions from a Network Model for Type 2 Diabetes

(2013) Deniz Rende et al.   PLoS One

Associations of body mass index and insulin resistance with leptin, adiponectin, and the leptin-to-adiponectin ratio across ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)

(2012) Laura J. Rasmussen-Torvik et al.   ANNALS OF EPIDEMIOLOGY

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

(2012) Minako Imamura et al.   HUMAN MOLECULAR GENETICS

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Confirmation of ALDH2 as a Major Locus of Drinking Behavior and of Its Variants Regulating Multiple Metabolic Phenotypes in a Japanese Population

(2011) Fumihiko Takeuchi et al.   CIRCULATION JOURNAL

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

(2011) Z. Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits

(2011) Young Jin Kim et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

A Novel PAX4 Mutation in a Japanese Patient with Maturity-Onset Diabetes of the Young

(2011) Wakako Jo et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Common Genetic Variation in GLP1R and Insulin Secretion in Response to Exogenous GLP-1 in Nondiabetic Subjects: A pilot study

(2010) A. Sathananthan et al.   DIABETES CARE

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Identification of New Genetic Risk Variants for Type 2 Diabetes

(2010) Xiao Ou Shu et al.   PLoS Genetics

A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese

(2010) Fuu-Jen Tsai et al.   PLoS Genetics

BMI and Diabetes Risk in Singaporean Chinese

(2009) A. O. Odegaard et al.   DIABETES CARE

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

(2009) Feng Xu et al.   HYPERTENSION RESEARCH

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS