Review
Health Care Sciences & Services
Stephana J. Moss, Krista Wollny, Therese G. Poulin, Deborah J. Cook, Henry T. Stelfox, Amanda Roze des Ordons, Kirsten M. Fiest
Summary: The study synthesized outcomes of ICU bereavement interventions for informal caregivers, showing sparse evidence and lack of support for the use of such interventions to help them cope with grief.
BMC PALLIATIVE CARE
(2021)
Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Article
Health Care Sciences & Services
Luis Sousa, Laurencia Gemito, Rogerio Ferreira, Lara Pinho, Cesar Fonseca, Manuel Lopes
Summary: This study aims to identify the current state of knowledge about programs targeting the needs of family caregivers or informal caregivers, and to discuss the development of intervention models for improving their experiences, health, and well-being.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Nursing
Charlotte C. Maartmann-Moe, Marianne Trygg Solberg, Marie Hamilton Larsen, Simen A. Steindal
Summary: This study conducted a qualitative systematic review and meta-synthesis to identify and synthesize evidence of adult patients' memories from their stay in the intensive care unit. Three main themes emerged from the review, including surreal dreams and delusions, varied care experiences, and memories of vulnerability and near-death experiences.
Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Critical Care Medicine
Kirstine N. la Cour, Nina C. Andersen-Ranberg, Sarah Weihe, Lone M. Poulsen, Camilla B. Mortensen, Cilia K. W. Kjer, Marie O. Collet, Stine Estrup, Ole Mathiesen
Summary: Hypoactive delirium is the most common motor subtype in critically ill patients. Mixed delirium has the worst outcomes and receives more pharmacological interventions compared to other subtypes. Standardization in delirium research is needed.
Review
Health Care Sciences & Services
A. C. M. Brekelmans, Dharmanand Ramnarain, Sjaak Pouwels
Summary: This review examines the psychological impact on relatives of deceased ICU patients. The study found that a bereavement strategy consisting of a communication strategy and a brochure can reduce the appearance of symptoms of PTSD, anxiety, and depression. The use of a brochure, condolence card, and phone call as bereavement support can lower the risk of prolonged grief.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Review
Multidisciplinary Sciences
Rafael del-Pino-Casado, Emilia Priego-Cubero, Catalina Lopez-Martinez, Vasiliki Orgeta
Summary: There is a significant positive association between subjective caregiver burden and anxiety symptoms in informal caregivers. Addressing subjective caregiver burden may help prevent clinically significant anxiety in the growing number of family carers worldwide. Subgroup analyses did not show differences by study design, sampling, control of confounders, or care-recipient characteristics.
Review
Geriatrics & Gerontology
Bing Ye, Tuck-Voon How, Charlene H. Chu, Alex Mihailidis
Summary: Dementia greatly impacts the quality of life of both people living with dementia and their family caregivers, with dementia care apps showing potential to improve their quality of life and reduce caregivers' burden. However, there is a lack of understanding regarding the needs and privacy concerns related to these apps.
Review
Infectious Diseases
Bruno Viaggi, Alice Cangialosi, Martin Langer, Carlo Olivieri, Andrea Gori, Alberto Corona, Stefano Finazzi, Antonello Di Paolo
Summary: The clinical outcome of severe infections in ICU patients depends on multiple factors, including early administration of chemotherapies and comorbidities. Different antibacterial drugs have variable tissue penetration rates, and the correlation between plasma and tissue concentrations may be inconsistent. This review focuses on antibacterial drugs that act as protein synthesis inhibitors and disrupt DNA structure and function. It found that fluoroquinolones, macrolides, linezolid, and tigecycline have excellent diffusion into epithelial lining fluid, which is crucial for the treatment of ventilator and healthcare-associated pneumonia. Some drugs also show high penetration rates in cerebrospinal fluid, skin, and soft tissues. Further studies are needed to improve understanding of drug tissue penetration, especially in the presence of factors that may affect drug pharmacokinetics.
Review
Infectious Diseases
Stefano Finazzi, Giacomo Luci, Carlo Olivieri, Martin Langer, Giulia Mandelli, Alberto Corona, Bruno Viaggi, Antonello Di Paolo
Summary: The diffusion of antimicrobial drugs within tissues is crucial for treating infections in critically ill patients. However, the unique physiopathology of these patients can significantly affect the pharmacokinetics of drugs and their distribution in the body. This review explores the tissue distribution of beta-lactams and other antimicrobials in critically ill patients, finding that the passage of drugs within tissues varies greatly and there is a large interindividual variability. Off-label dosing regimens may be an effective solution to overcome these challenges.
Review
Multidisciplinary Sciences
Shodai Yoshihiro, Shunsuke Taito, Kota Yamauchi, Shunsuke Kina, Takero Terayama, Yusuke Tsutsumi, Yuki Kataoka, Takeshi Unoki
Summary: This study conducted follow-ups with critically ill patients and their informal caregivers after ICU discharge, focusing on the impact of psychological interventions on their mental health. The results showed that follow-up had little effect on the prevalence of depression and PTSD among patients, but increased the prevalence of depression and PTSD among informal caregivers. This suggests that the effect of ICU follow-up with psychological intervention on mental health outcomes is uncertain.
Review
Nursing
Giulia Lamiani, Federica Bonazza, Silvia Del Negro, Elaine C. Meyer
Summary: This systematic review identified the positive effects of child/adolescent visitation in adult intensive care units, such as better understanding of reality and preservation of family relationships. Individual characteristics (e.g., age, past traumatic experiences) and organizational factors (e.g., facilitated visit) had an impact on the experience of visiting. Most children/adolescents presented anxiety and depression symptoms regardless of visitation, highlighting the importance of addressing these mental health issues.
INTENSIVE AND CRITICAL CARE NURSING
(2021)
Review
Nutrition & Dietetics
Aileen Hill, Gunnar Elke, Arved Weimann
Summary: Nutritional therapy for critically ill patients should be tailored to individual patients, focusing on the phase of critical illness, metabolic tolerance, leading symptoms, and comorbidities. Personalized and disease-specific nutritional therapy in the ICU requires an interdisciplinary approach and frequent reevaluation for optimal clinical outcomes.
Review
Nursing
Weijing Sui, Xiaoyan Gong, Xiaoting Qiao, Lixin Zhang, Junning Cheng, Jing Dong, Yiyu Zhuang
Summary: This study examines and synthesizes the qualitative data on family members' perceptions of surrogate decision-making in the intensive care unit. The findings reveal that individuals undergo complex emotional and cognitive processes during surrogate decision-making, and families as a whole experience different processes and outcomes. Furthermore, the decision-making process reflects society's perceptions of the medical system.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Health Care Sciences & Services
Lesley Pritchard, Katherine S. Bright, Catharine M. Walsh, Susan Samuel, Queenie K. W. Li, Krista Wollny, Marinka Twilt, Lianne Tomfohr-Madsen, Linda Pires, Gina Dimitropoulos
Summary: This study explores the unique contributions, opportunities, and challenges of paediatric clinician-scientists, finding that they have a unique position in advancing clinical practice and research, but also face significant challenges. The study suggests that training programs should focus on developing essential skills and knowledge for future clinician-scientists.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Ruth Ann Marrie, John D. Fisk, Randy Walld, James M. Bolton, Jitender Sareen, Scott B. Patten, Alexander Singer, Lisa M. Lix, Carol A. Hitchon, Renee El-Gabalawy, Alan Katz, James J. Marriott, Charles N. Bernstein
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Anesthesiology
Kirsten Deemer, Brittany Myhre, Stephanie Oviatt, Michelle Parsons, Mallory Watson, Karolina Zjadewicz, Andrea Soo, Kirsten Fiest, Juan Posadas-Calleja
Summary: This study assessed the feasibility of an occupational therapist (OT)-guided cognitive intervention protocol in critically ill patients in the ICU. It demonstrated that the protocol was feasible and the majority of intervention sessions were successfully completed.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Review
Critical Care Medicine
Vincent I. Lau, Ryan Donnelly, Sehar Parvez, Jivanjot Gill, Sean M. Bagshaw, Ian M. Ball, John Basmaji, Deborah J. Cook, Kirsten M. Fiest, Robert A. Fowler, Jonathan F. Mailman, Claudio M. Martin, Bram Rochwerg, Damon C. Scales, Henry T. Stelfox, Alla Iansavichene, Eric J. Sy
Summary: This study evaluated the impact of direct discharge home (DDH) from ICUs compared to ward transfer on safety outcomes such as readmissions, emergency department visits, and mortality. Six studies were included, and three high-quality studies involving 49,376 patients were subject to meta-analysis. The findings suggest that DDH from ICUs may have no significant difference in safety outcomes compared to ward transfer, but the evidence is of low certainty.
CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Amir Khakban, Elisabet Rodriguez Llorian, Kristina D. Michaux, Scott B. Patten, Anthony Traboulsee, Jiwon Oh, Larry D. Lynd
Summary: The objective of this study was to quantify the excess health care costs of multiple sclerosis (MS) in British Columbia, Canada. The study found that the excess cost of MS was $6,881 per patient-year, with inpatient, outpatient, and medication costs accounting for 25%, 10%, and 65% of the excess costs, respectively. Patients receiving disease-modifying therapy (DMT) and those with a history of hospitalization had higher excess costs. The study suggests that early diagnosis and timely use of DMTs could help reduce costs and improve patients' quality of life.
Letter
Psychiatry
Scott B. B. Patten, Gina Dimitropoulos, Jeanne V. A. Williams, Sandy Rao, Mina Fahim, Vandad Sharifi, Pardis Pedram, Andrew G. M. Bulloch
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Samreen Shafiq, Paul Everett Ronksley, Tayler Dawn Scory, Meghan Jessica Elliott, Andrew Gabriel McKay Bulloch, Scott Burton Patten
Summary: Despite the clinical efficacy of lithium, its use is believed to be declining. This study used administrative health data to examine new and prevalent lithium users and rates of discontinuation over a 10-year period. The results suggest a decrease in total lithium users, with potential stabilization or reversal in recent years. Discontinuation rates were highest among 18-24 year olds.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Gastroenterology & Hepatology
Ruth Ann Marrie, John D. Fisk, Casandra Dolovich, Lisa M. Lix, Lesley A. Graff, Scott B. Patten, Charles N. Bernstein
Summary: This study compared the psychometric properties of multiple fatigue scales in individuals with inflammatory bowel disease (IBD). The Fatigue Impact Scale (FIS), Modified Fatigue Impact Scale-IBD (MFIS-IBD), and Daily Fatigue Impact Scale (DFIS) showed adequate validity and reliability for assessing fatigue in IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Critical Care Medicine
Antonio Paulo Nassar, Eugene Wesley Ely, Kirsten M. Fiest
INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xia Qiu, Yin Wu, Ying Sun, Brooke Levis, Jizhou Tian, Jill T. Boruff, Pim Cuijpers, John P. A. Ioannidis, Sarah Markham, Roy C. Ziegelstein, Simone N. Vigod, Andrea Benedetti, Brett Thombs, Chen He, Ankur Krishnan, Parash Mani Bhandari, Dipika Neupane, Zelalem Negeri, Mahrukh Imran, Danielle B. Rice, Marleine Azar, Matthew J. Chiovitti, Simon A. Gilbody, Lorie B. Kloda, Scott D. Patten, Nicholas Mitchell, Ruben Alvarado, Jacqueline Barnes, Cheryl Tatano Beck, Carola Bindt, Humberto Correa, Tiago Castro e Couto, Genesis Chorwe-Sungani, Valsamma Eapen, Nicolas Favez, Ethel Felice, Gracia Fellmeth, Michelle Fernandes, Sally Field, Barbara Figueiredo, Jane R. W. Fisher, Eric P. Green, Simone Honikman, Louise M. Howard, Pirjo A. Kettunen, Jane Kohlhoff, Zoltan Kozinszky, Angeliki A. Leonardou, Michael Maes, Pablo Martinez, Sandra Nakic Rados, Daisuke Nishi, Susan J. Pawlby, Tamsen J. Rochat, Heather J. Rowe, Deborah J. Sharp, Alkistis Skalkidou, Johanne Smith-Nielsen, Alan Stein, Kuan-Pin Su, Inger Sundstroem-Poromaa, Meri Tadinac, S. Darius Tandon, Iva Tendais, Annamaria D. Toereki, Thach Tran, Kylee Trevillion, Katherine S. Turner, Mette Vaever, Thandi M. van Heyningen, Johann Vega-Dienstmaier, Karen A. Wynter, Kimberly Yonkers
Summary: Item 10 of the EPDS assesses self-harm thoughts but may also elicit concerns about accidental self-harm. The EPDS-9, which omits item 10, is sometimes used in research due to concerns about its implications. A meta-analysis of individual participant data showed that EPDS-9 performs similarly to the full EPDS in detecting major depression among pregnant and postpartum women.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Jessica Heerde, Rohan Borschmann, Jesse Young, Stuart A. Kinner, Susan M. Sawyer, George C. Patton
Summary: This systematic review aims to synthesize international literature on mortality rates and risk and protective factors among people who have experienced homelessness. The study will search for cohort studies examining mortality in this population and assess the quality of included studies. The findings will be disseminated through academic channels.
Article
Medicine, General & Internal
Shaza Almweisheer, Charles N. Bernstein, Lesley A. Graff, Scott B. Patten, James Bolton, John D. Fisk, Carol A. Hitchon, James J. Marriott, Ruth Ann Marrie
Summary: This study aimed to assess the mental health of individuals with immune-mediated inflammatory diseases (IMID) and compare the differences across different types of diseases. The study found that over half of the participants with multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) reported flourishing mental health, with similar levels across the disease groups.
Article
Medicine, General & Internal
Anmol Shahid, Corson Johnstone, Bonnie G. Sept, Shelly Kupsch, Andrea Soo, Kirsten M. Fiest, Henry Thomas Stelfox
Summary: This study aims to develop an educational module on family coaching during spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs), and evaluate its feasibility and acceptability through pilot testing. The results of this study will determine whether further research is warranted to explore the value of family coaching during these procedures.
Article
Public, Environmental & Occupational Health
Amanda Wurz, Kelsey Ellis, Delaney Duchek, Mannat Bansal, Marie-Eve Carrier, Lydia Tao, Laura Dyas, Linda Kwakkenbos, Brooke Levis, Ghassan El-Baalbaki, Danielle B. Rice, Yin Wu, Richard S. Henry, Laura Bustamante, Sami Harb, Shannon Hebblethwaite, Scott B. Patten, Susan J. Bartlett, John Varga, Luc Mouthon, Sarah Markham, Brett D. Thombs, S. Nicole Culos-Reed
Summary: This study explored the acceptability and successful implementation of the SPIN-CHAT program and trial, and the results indicate that both the research team members and trial participants had a positive perception of the program and trial. These findings are crucial for the design and improvement of other supportive care programs aiming to promote psychological health during and beyond the COVID-19 pandemic.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Brooke Allemang, Susan Samuel, Katelyn Greer, Keighley Schofield, Karina Pintson, Megan Patton, Marcela Farias, Kathleen C. C. Sitter, Scott B. B. Patten, Andrew S. S. Mackie, Gina Dimitropoulos
Summary: This study examines the transition readiness of youth with co-occurring chronic health and mental health conditions using a combination of quantitative and qualitative data. The findings demonstrate that widely used tools for measuring transition readiness do not address the complex needs of this group.
HEALTH EXPECTATIONS
(2023)