Article
Medicine, General & Internal
Sophie Richter, Stefan Winzeck, Evgenios N. Kornaropoulos, Tilak Das, Thijs Vande Vyvere, Jan Verheyden, Guy B. Williams, Marta M. Correia, David K. Menon, Virginia F. J. Newcombe
Summary: The study found that white matter injury is associated with symptoms after mild traumatic brain injury (mTBI), and performing imaging within 72 hours of injury can better predict clinical recovery. This could help in identifying high-risk patients for clinical follow-up or interventional trials.
Article
Critical Care Medicine
Jonas Stenberg, Live Eikenes, Kent Goran Moen, Anne Vik, Asta K. Haberg, Toril Skandsen
Summary: This prospective cohort study investigated the associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild traumatic brain injury (mTBI). Patients who developed PPCS had poorer white matter microstructural integrity acutely after the injury, compared with patients who recovered and healthy controls. Differences became less pronounced when cognitive reserve was controlled for, suggesting that pre-existing individual differences in axonal integrity accounted for some of the observed differences.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Medicine, General & Internal
Sung-Ho Jang, Min-Jye Cho
Summary: This review paper discusses the application of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in the diagnosis of traumatic axonal injury (TAI) in individuals with concussion or mild traumatic brain injury (mTBI). While several hundred DTI-based studies have reported TAI in concussion or mTBI, there are fewer case studies focusing on individual patients. The summary of these studies suggests that DTI can be used as a non-invasive tool for determining the presence and severity of TAI in individual patients with concussion or mTBI. However, certain conditions need to be met for an accurate diagnosis, and further studies are required to improve the precision of TAI diagnosis in individual patients.
Article
Critical Care Medicine
Jonas Stenberg, Toril Skandsen, Kent Goran Moen, Anne Vik, Live Eikenes, Asta K. Haberg
Summary: This prospective cohort study aimed to characterize diffusion changes in white matter the first year after mild traumatic brain injury (MTBI). The results showed that there were significant differences in white matter diffusion between MTBI patients and controls at 72 h, 3 months, and 12 months. These findings suggest that there are differences in white matter integrity between MTBI patients and healthy individuals.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Cell Biology
Sung Ho Jang, You Sung Seo
Summary: Diffusion tensor tractography is a valuable method to evaluate axonal injury in concussion (mTBI) patients. It reveals characteristic features such as tearing, narrowing, and discontinuations of neural tracts, which provide insights into the extent and patterns of axonal injury. Axonal injury in concussion (mTBI) patients is characterized by their occurrence in long neural tracts and multiple injuries. However, the corticospinal tract discontinuation is commonly observed in diffuse axonal injury, while partial tearing and narrowing in subcortical white matter are frequently observed in concussion (mTBI) patients. These differences suggest that the forces causing axonal injury in concussion (mTBI) patients are weaker than those in diffuse axonal injuries. Additionally, the presence of collateral branches in concussion (mTBI) patients indicates a relatively weaker impact on the brain compared to diffuse axonal injury. The characteristics of axonal injury in concussion (mTBI) patients reviewed in this study provide valuable supplementary information for the diagnosis of axonal injury in concussion (mTBI) patients.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B. Jung, Tim L. T. Wiegand, Elena M. Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington, Twishi Puri, Yogesh Rathi, Michael J. Coleman, Ofer Pasternak, Mark S. George, Thomas W. Mcallister, Ross Zafonte, Murray B. Stein, Christine E. Marx, Martha E. Shenton, Inga K. Koerte
Summary: This study analyzed diffusion and structural MRI data of 278 participants with and without military background, and found microstructural alterations at the gray matter/white matter boundary of the brain after mild traumatic brain injury (mTBI) that were associated with post-concussive symptom severity, functional, and cognitive impairment. These findings suggest that microstructural changes at the gray matter/white matter boundary may be sensitive markers of adverse long-term outcomes following mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Ashley L. Ware, Catherine Lebel, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates
Summary: This prospective cohort study investigated the trajectories of brain gray matter macrostructure after pediatric mild traumatic brain injury (mTBI). The study found that mTBI can alter the typical course of cortical gray matter thinning up to 6 months postinjury, even after symptoms typically abate in most children. Therefore, it is important to examine neurobiology in relation to clinical outcomes and within a neurodevelopmental framework.
Article
Clinical Neurology
Hakan Ashina, Rune H. Christensen, Haidar Muhsen Al-Khazali, Afrim Iljazi, Daniel Tolnai, Anna K. Eigenbrodt, Henrik B. W. Larsson, Henrik W. Schytz, Ulrich Lindberg, Faisal Mohammad Amin
Summary: This study compared the prevalence of white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) in patients with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) and healthy controls using magnetic resonance imaging (MRI) techniques. The results showed no significant differences in the numbers of WMHs and CMBs between the two groups. These findings suggest that future studies should focus on other MRI techniques to identify radiologic biomarkers of post-traumatic headache.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Critical Care Medicine
Eva M. Palacios, Esther L. Yuh, Christine L. Mac Donald, Ioanna Bourla, Jamie Wren-Jarvis, Xiaoying Sun, Mary J. Vassar, Ramon Diaz-Arrastia, Joseph T. Giacino, David O. Okonkwo, Claudia S. Robertson, Murray B. Stein, Nancy Temkin, Michael A. McCrea, Harvey S. Levin, Amy J. Markowitz, Sonia Jain, Geoffrey T. Manley, Pratik Mukherjee
Summary: This multi-center study aimed to investigate the acute effects of mild traumatic brain injury (mTBI) on white matter (WM) microstructure and its prognostic significance. The results showed that there were changes in WM microstructure at two weeks and six months post-injury, which were associated with long-term outcome. Diffusion tensor imaging (DTI) provides reliable imaging biomarkers for assessing dynamic WM microstructural changes after mTBI, which could be useful for patient selection and treatment response evaluation in clinical trials.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Rehabilitation
Linda Fordal, Jonas Stenberg, Grant L. Iverson, Simen B. Saksvik, Migle Karaliute, Anne Vik, Alexander Olsen, Toril Skandsen
Summary: This study aimed to examine the trajectories of persistent postconcussion symptoms (PPCS) after mild traumatic brain injury (MTBI) and investigate the factors associated with symptom reporting. The results showed a similar prevalence of moderate to severe PPCS in the MTBI group at 3 and 12 months post-injury. Individual trajectory analysis revealed considerable change in both symptom severity and total scores over time in the MTBI group. In addition, the presence of intracranial lesions was associated with a higher likelihood of improvement. Female gender and personal factors such as reduced employment, pain, poor sleep, low resilience, high neuroticism and pessimism, and a psychiatric history were associated with persistent symptoms. In conclusion, personal factors play an important role in the presence of persistent symptoms during the first year after MTBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Hakan Ashina, Afrim Iljazi, Haidar M. Al-Khazali, Thien Phu Do, Anna K. Eigenbrodt, Eigil L. Larsen, Amalie M. Andersen, Kevin J. Hansen, Karoline B. Brauner, Basit Ali Chaudhry, Casper E. Christensen, Faisal Mohammad Amin, Henrik W. Schytz
Summary: The study found that intravenous infusion of CGRP can induce migraine-like headache in people with persistent post-traumatic headache attributed to mild TBI, emphasizing the importance of CGRP in the genesis of migraine-like headache. Further research is needed to determine the potential contribution of other signaling molecules to the disease mechanisms underlying post-traumatic headache.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Sean O. Mahoney, Nahian F. Chowdhury, Van Ngo, Phoebe Imms, Andrei Irimia
Summary: This study reveals that intracortical demyelination after mild traumatic brain injury is significantly more severe than in typical aging, with different regions of the brain affected differently. Occipital regions may be more susceptible to primary injury, while temporal, cingulate, and insular regions are more vulnerable to later manifestations of injury sequelae.
FRONTIERS IN NEUROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Eunkyung Kim, Roh-Eul Yoo, Min Yong Seong, Byung-Mo Oh
Summary: Diffusion tensor imaging studies of mild traumatic brain injury (mTBI) in adults show a high variability in reported white matter integrity changes, with long-term neurodegenerative processes and possible recovery. Longitudinal cohort studies are needed for further understanding of brain changes after mTBI.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Neurosciences
Yuwen Hung, Marlee Vandewouw, Zahra Emami, Sonya Bells, Nicole Rudberg, Leodante da Costa, Benjamin T. Dunkley
Summary: Using multi-modality imaging methods, this study found disruptions in brain-behavior interactions related to working memory in patients with mild traumatic brain injury (mTBI), particularly in the hippocampal-prefrontal and amygdala circuits. These disruptions may leave mTBI patients vulnerable to increased environmental demands exerting memory resources, leading to cognitive and emotional psychopathologies.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Fengzhao Zhu, Yulong Wang, Xiangchuang Kong, Yuan Liu, Lian Zeng, Xirui Jing, Sheng Yao, Kaifang Chen, Lian Yang, Xiaodong Guo
Summary: The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for acute traumatic cervical SCI. Lower intramedullary lesion length and intramedullary hemorrhage length, and higher fractional anisotropy value and connection rates of fiber tractography are linked to better neurological outcomes.
EUROPEAN SPINE JOURNAL
(2022)
Review
Neurosciences
Odile A. van den Heuvel, Premika S. W. Boedhoe, Sara Bertolin, Willem B. Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun S. Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A. van Wingen, Je-Yeon Yun, Chris Vriend, H. Blair Simpson, Daan van Rooij, Marcelo Q. Hoexter, Martine Hoogman, Jan K. Buitelaar, Paul Arnold, Jan C. Beucke, Francesco Benedetti, Irene Bollettini, Anushree Bose, Brian P. Brennan, Alessander S. De Nadai, Kate Fitzgerald, Patricia Gruner, Edna Gruenblatt, Yoshiyuki Hirano, Chaim Huyser, Anthony James, Kathrin Koch, Gerd Kvale, Luisa Lazaro, Christine Lochner, Rachel Marsh, David Mataix-Cols, Pedro Morgado, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Christopher Pittenger, Y. C. Janardhan Reddy, Joao R. Sato, Noam Soreni, S. Evelyn Stewart, Stephan F. Taylor, David Tolin, Sophia I. Thomopoulos, Dick J. Veltman, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Paul M. Thompson, Dan J. Stein
Summary: Neuroimaging has significantly advanced our understanding of OCD's neurobiology, with ENIGMA consortium's collaborative efforts enhancing statistical power. Their work involves samples from multiple countries and regions, utilizing machine learning techniques for research, contributing to the development of neurobiological models of OCD and global scientific collaboration.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Luis F. H. Basile, Joao R. Sato, Henrique A. Pasquini, Bruna Velasques, Pedro Ribeiro, Renato Anghinah
Summary: Analysis of non-averaged SPs showed highly variable generators across subjects, with no specific area common to all participants. Comparisons of combined generators between different tasks and sessions revealed higher correlations between tasks than between sessions. Results support the hypothesis of individual-specific patterns of cortical activity, independent of task conditions.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lucas R. Trambaiolli, Juliana Tossato, Andre M. Cravo, Claudinei E. Biazoli, Joao R. Sato
Summary: The study demonstrated the possibility of inferring human emotional states using brain signal measurements, specifically with fNIRS signals and a specific classifier. By utilizing a small number of biologically relevant features, significant classification accuracies of emotional states were achieved in a subject-independent manner. Further research is needed to explore better combinations of features and classifiers for improved results in affective decoding.
Article
Neurosciences
Amanda Yumi Ambriola Oku, Joao Ricardo Sato
Summary: Increasing student engagement in online classes is a challenge, with tools like fNIRS being used to monitor brain activity and predict performance. Channels F4-F6 and AF3-AFz were found to be most relevant for predicting student engagement during a video lecture.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Candida Barreto, Guilherme de Albuquerque Bruneri, Guilherme Brockington, Hasan Ayaz, Joao Ricardo Sato
Summary: This study proposes a novel methodological approach for fNIRS multi-brain analysis using SVR to predict one brain activity time series using another as the predictor. The results demonstrate that SVR can be used for channel-wise predictions across individuals, and teachers' cortical activity can predict students' brain hemodynamic response.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Lea Baecker, Jessica Dafflon, Pedro F. da Costa, Rafael Garcia-Dias, Sandra Vieira, Cristina Scarpazza, Vince D. Calhoun, Joao R. Sato, Andrea Mechelli, Walter H. L. Pinaya
Summary: Research suggests that using machine learning models for age prediction based on brain features can aid in detecting aging abnormalities, with models trained on voxel-level data with principal component analysis performing the best.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Joyce de Souza Zanirato Maia, Ana Paula Arantes Bueno, Joao Ricardo Sato
Summary: Educational indicators are used to evaluate the quality of the educational system and their impact is often associated with economic and social factors. This study aimed to assess factors related to school performance using a dataset from Brazilian schools, generating different models to predict performance. The non-linear model was found to predict the best performance, and the heterogeneity of variable importance across school cycles and regions could help inform the development of public educational policies.
Article
Psychiatry
Fabrizio Piras, Federica Piras, Yoshinari Abe, Sri Mahavir Agarwal, Alan Anticevic, Stephanie Ameis, Paul Arnold, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan-Carl Beucke, Premika S. W. Boedhoe, Irene Bollettini, Silvia Brem, Anna Calvo, Kang Ik Kevin Cho, Valentina Ciullo, Sara Dallaspezia, Erin Dickie, Benjamin Adam Ely, Siyan Fan, Jean-Paul Fouche, Patricia Gruner, Deniz A. Guersel, Tobias Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Mariangela Iorio, Anthony James, Y. C. Janardhan Reddy, Christian Kaufmann, Kathrin Koch, Peter Kochunov, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Yuki Sakai, Eiji Shimizu, Daniela Simon, Helen Blair Simpson, Noam Soreni, Philipp Staempfli, Emily R. Stern, Philip Szeszko, Jumpei Takahashi, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Odile A. van den Heuvel, Gianfranco Spalletta, Francesca Assogna, Rosa Calvo, Stella J. de Wit, Morgan Hough, Masaru Kuno, Euripedes C. Miguel, Astrid Morer, Christopher Pittenger, Sara Poletti, Enrico Smeraldi, Joao R. Sato, Aki Tsuchiyagaito, Susanne Walitza, Ysbrand D. van der Werf, Daniela Vecchio, Mojtaba Zarei
Summary: The study investigated microstructural alterations in cortico-subcortical connections in OCD patients, finding significant FA reduction in certain brain regions in adults but not in children. Lower FA was associated with younger age of onset, longer duration of illness, and higher percentage of medicated patients.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Physics, Multidisciplinary
Adele Helena Ribeiro, Maciel Calebe Vidal, Joao Ricardo Sato, Andre Fujita
Summary: This study focuses on inferring Granger causality between networks' time series to understand information flow, proposing a theoretical framework for modeling time-varying graphs, showing that the spectral radius can be a reasonable estimate of some random graph model parameters, and demonstrating differences in G-causality intensity between brain hemispheres of controls and children diagnosed with ASD.
Article
Neurosciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Andre Zugman, Pedro Mario Pan, Ana Paula Arantes Bueno, Luciana Monteiro Moura, Ary Gadelha, Felipe Almeida Picon, Edson Amaro Jr, Giovanni Abrahao Salum, Euripedes Constantino Miguel, Luis Augusto Rohde, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski
Summary: The study found that the identification accuracy of the whole brain functional profile in children and adolescents is moderate at 38%, while the cortical volumetric profile has an accuracy of 95%. Among large-scale networks, the default-mode, frontoparietal, and dorsal-attention networks are the most discriminative. These results support the protracted development of specific individual structural and functional connectivity profiles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Mathematical & Computational Biology
Sergio Leonardo Mendes, Walter Hugo Lopez Pinaya, Pedro Pan, Joao Ricardo Sato
Summary: Despite ongoing challenges, this study successfully used brain structural MRI and a convolutional neural network to estimate gender, age, and mental health status, achieving satisfactory prediction results. The approach demonstrated the latest applications of machine learning in neuroimaging.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Raimundo da Silva Soares Jr, Katerina Lukasova, Maria Teresa Carthery-Goulart, Joao Ricardo Sato
Summary: This article discusses the possible contributions of eye-tracking (ET) to Educational Neuroscience through the use of this tool in schools. By having teachers view ET videos of students solving math problems, it was found that the tool could accurately predict student performance and provide insights into their cognitive strategies. Qualitative analysis was shown to be important in identifying students' gaze strategies and providing valuable feedback on student behavior.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Health Care Sciences & Services
Carmen Simone Grilo Diniz, Ana Carolina Arruda Franzon, Beatriz Fioretti-Foschi, Denise Yoshie Niy, Livia Sanches Pedrilio, Edson Amaro Jr, Joao Ricardo Sato
Summary: This study aims to develop and evaluate an information and communication strategy through a smartphone app to facilitate informed choices for safer and evidence-based care during the COVID-19 pandemic. The study includes a randomized controlled trial with an intervention group receiving information about childbirth options and a control group receiving information about diapers, comparing their alignment with guidelines for a positive childbirth experience. Overall, this innovative intervention has the potential to improve communication between women and providers during the pandemic.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Neuroimaging
Mateus G. Nogueira, Mateus Silvestrin, Candida S. F. Barreto, Joao Ricardo Sato, Rickson C. Mesquita, Claudinei Biazoli, Abrahao F. Baptista
Summary: Attention is a basic human function that is involved in cognitive processes. Functional Magnetic Resonance Imaging studies have shown that frontoparietal networks are associated with attentive performance, while default mode networks are associated with inattentive performance. This study used functional Near-Infrared Spectroscopy to investigate the differences in hemodynamic activity between fast and slow responses during a simple sustained attention task. The results revealed differences in medial frontal cortex and inferior parietal cortex channels, both before and after stimulus onset.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Behavioral Sciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Ana Paula Arantes Bueno, Arthur Caye, Pedro Mario Pan, Marcos Santoro, Jessica Honorato-Mauer, Giovanni Abrahao Salum, Marcelo Queiroz Hoexter, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski, Euripedes Constantino Miguel, Sintia Belangero, Luis Augusto Rohde
Summary: Neuroimaging studies suggest that brain development mechanisms may explain some ADHD symptoms. However, the mechanisms by which genetic factors influence brain development in relation to ADHD remain largely unknown. This study aimed to investigate the associations between an ADHD polygenic risk score and brain network functioning. The findings suggest correlations between the ADHD polygenic risk score and the segregation of cingulo-opercular networks and the default mode network, supporting the role of attentional networks and DMN in attention processes. However, these associations were not found at follow-up.
GENES BRAIN AND BEHAVIOR
(2023)
