Review
Cell Biology
Jun Sun, Yong-Guo Zhang
Summary: VDR plays a crucial role in the biological functions of vitamin D and acts as a transcriptional factor regulating the expression of target genes; Research shows that VDR regulation of intestinal barriers influences health and disease; Understanding the mechanisms by which VDR signaling regulates intestinal barrier functions can help develop efficient therapeutic strategies for human diseases.
Article
Physiology
Senyue Liu, Lin Luo, Fengyuan Zuo, Xiaoli Huang, Liang Zhong, Sha Liu, Yi Geng, Yangping Ou, Defang Chen, Wenlong Cai, Yongqiang Deng
Summary: This study reveals the toxic effect of ammonia nitrogen stress on the intestine of Pelteobagrus fulvidraco. Ammonia nitrogen stress causes structural damage to the intestine, reduction in mucous cells, and decreased enzyme activity. Ultrastructural pathology shows sparse microvilli, badly degraded tight junctions, and impaired intestinal mucosal barrier. Immunohistochemistry and qRT-PCR analysis further confirm the damage to the intestinal mucosal barrier and the occurrence of intestinal inflammation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Fisheries
Hongxia Zhao, Dongqiang Hou, Peijia Li, Min Li, Bing Chen, Xifeng Zhu, Junming Cao
Summary: The study investigated the effects of dietary tributyrin on growth, intestinal health, inflammatory response, and antioxidant status in juvenile Pelteobagrus fulvidraco. The results showed that tributyrin improved growth and lipid deposition, but decreased inflammatory response in the fish. These effects may be attributed to modulation of tight junction proteins and lipid metabolism-related genes expression, as well as activation of the antioxidant system.
AQUACULTURE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun Sun
Summary: Inflammatory bowel disease is a chronic inflammation of the GI tract, including Crohn's disease and ulcerative colitis, associated with microbiota dysbiosis and vitamin D deficiency. Further studies are needed to explore the mechanisms and therapeutic potential related to vitamin D/VDR in gut microbiota modulation for IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Peijia Li, Dongqiang Hou, Hongxia Zhao, Hairui Wang, Kai Peng, Junming Cao
Summary: Dietary Clostridium butyricum has positive effects on growth performance and resistance to ammonia stress in yellow catfish by increasing intestinal short-chain fatty acid (SCFA) productions, upregulating genes encoding tight junction proteins, downregulating transcription of proinflammatory factors Il-1 and Il-8, and inhibiting the Mlck/Nf-kappa b signaling pathway.
AQUACULTURE NUTRITION
(2022)
Article
Nutrition & Dietetics
Junrui Cheng, Emilio Balbuena, Baxter Miller, Abdulkerim Eroglu
Summary: The study found that beta-carotene can alleviate colonic inflammation and enhance tight junction proteins levels in an in vitro epithelial cell model, potentially improving barrier function.
FRONTIERS IN NUTRITION
(2021)
Article
Food Science & Technology
Zheng Cao, Jinsong Gao, Wanyue Huang, Juli Yan, Anshan Shan, Xiang Gao
Summary: Curcumin protects against Deoxynivalenol-induced disruption of intestinal epithelial barrier by regulating apoptotic pathway and TJs pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Fisheries
Peijia Li, Dongqiang Hou, Hongxia Zhao, Wenqing Huang, Kai Peng, Junming Cao
Summary: The experimental trial examined the effects of dietary pyridoxine on the growth performance, intestinal enzymatic activities, and antioxidant properties of Pelteobagrus fulvidraco. The results demonstrated that an appropriate amount of pyridoxine supplementation could improve the growth performance, intestinal health, and antioxidant capacity of the yellow catfish.
AQUACULTURE REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
M. Pena-Rodriguez, N. Vega-Magana, Leonel Garcia-Benavides, J. S. Zepeda-Nuno, G. Y. Gutierrez-Silerio, L. A. Gonzalez-Hernandez, J. F. Andrade-Villanueva, S. Del Toro-Arreola, A. L. Pereira-Suarez, M. R. Bueno-Topete
Summary: The study showed that butyrate effectively regulates inflammatory response, tight junction protein expression, and limits bacterial diversity loss in cirrhosis patients. This research suggests that butyrate could be an interesting postbiotic metabolomic intervention for intestinal epithelium dysfunction in liver disease.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yong-Guo Zhang, Yinglin Xia, Jilei Zhang, Shreya Deb, Shari Garrett, Jun Sun
Summary: The microbiota plays a critical role in regulating intestinal and extraintestinal health. This study investigates the potential connection between the intestinal microbiome and breast cancer. Through the examination of mice with VDR deficiency and dysbiosis, the researchers found that VDR deficiency leads to an increased susceptibility to breast cancer. Moreover, they identified the mechanisms by which VDR deficiency disrupts gut health and increases the risk of breast tumorigenesis. Treatment with beneficial bacteria or their metabolites showed promising results in reducing breast tumors and improving gut health.
Article
Physiology
Junru Hu, Hongxia Zhao, Guoxia Wang, Yuping Sun, Lei Wang
Summary: This study investigated the metabolic and intestinal microbiota changes in yellow catfish under cold stress. The results showed that cold stress increased the consumption of glucose and triglycerides in yellow catfish, as well as activated several biological processes including thermogenesis and oxidative phosphorylation. Furthermore, cold stress reduced the diversity of intestinal microbiota and increased the abundance of pathogenic bacteria.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Xu Zhou, Gui-Rong Zhang, Wei Ji, Ze-Chao Shi, Xu-Fa Ma, Zun-Lan Luo, Kai-Jian Wei
Summary: The study revealed that the immune response of yellow catfish against E. ictaluri infection is mainly manifested in the spleen and liver, with key gene expression peaking at 72 hours post-infection. Cytokines were continuously transcribed in the spleen, while the liver mainly secreted components of the complement system, and metabolic regulation was activated from 12 to 120 hours post-infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Shidong Wang, Xue Li, Muzi Zhang, Haibo Jiang, Rixin Wang, Yunxia Qian, Ming Li
Summary: The study found that ammonia accumulated in the intestine and muscle, disrupted protein digestive enzyme function, altered amino acid composition in muscle, and increased the activities of alanine aminotransferase and aspartate aminotransferase in muscle. Additionally, ammonia stress reduced diversity, richness, and altered microbiota structure in the intestine, with an increase in the abundance of Fusobacteria and beneficial microbiota Cetobacterium.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Zhuoran Han, Lunhua Ge, Siyi Wen, Jingfeng Sun
Summary: In this study, bacterial infection induced intestinal inflammation and increased intestinal permeability in tongue sole. Gene expression patterns of inflammatory factors, tight junction molecules, and keratins were altered in response to the infection. These findings provide important evidence for the relationship between intestinal inflammation and dysfunction of the intestinal physical barrier.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Wei Li, Bingdong Liu, Zhihong Liu, Yulong Yin, Guohuan Xu, Mulan Han, Liwei Xie
Summary: The study found that histamine-rich diets resulted in severe abnormalities in the intestine of yellow catfish, including reduced villi length and number. Additionally, histamine-rich diets altered gut microbiota composition and diversity, impacting the stability of the intestinal microbiota community. Pearson correlation analysis identified certain bacterial species that were negatively correlated with pro-inflammatory factors and positively correlated with anti-inflammatory factors, suggesting their potential anti-inflammatory properties.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)