Article
Gastroenterology & Hepatology
Sarah C. McKay, Melissa L. DeSouza, Christy M. Dunst, Kevin M. Reavis, Daniel Davila Bradley, Steven R. DeMeester
Summary: Despite nearly half of patients ultimately diagnosed with EA having undergone one or more SCs, only 18% of patients had an EGD prior to the EA diagnosis. In these patients, most had GERD symptoms, were using acid suppression medications or had an ASGE indication for a screening EGD. Therefore, adding an EGD at the time of SC in these patients may have allowed for the early endoscopic detection of BE or EA and represents a missed opportunity to intervene in the natural history of this disease.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Sanne J. M. Hoefnagel, Jurjen J. Boonstra, Marjolein J. A. M. Russchen, Kausilia K. Krishnadath
Summary: Esophageal adenocarcinoma (EAC) is a major subtype of esophageal cancer with most patients being asymptomatic in the early stages. Current treatment involves chemotherapy, radiotherapy, and surgical resection, but there is heterogeneity in treatment response. Personalized treatment approaches could lead to better patient outcomes.
Article
Gastroenterology & Hepatology
Seitaro Shimada, Yohei Yabuuchi, Noboru Kawata, Yuki Maeda, Masao Yoshida, Yoichi Yamamoto, Tatsunori Minamide, Kohei Shigeta, Kazunori Takada, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
Summary: This study aimed to elucidate the endoscopic causes and characteristics of missed gastric cancers (MGCs) after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). The results showed that the endoscopic causes of MGCs included perceptual errors, exposure errors, sampling errors, and inadequate preparation. Logistic regression analysis revealed the risk factors for perceptual errors and the sites of exposure errors.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Claire Gordon, Desmond Chee, Ben Hamilton, Neel M. Heerasing, Peter Hendy, Neil Chanchlani, Simeng Lin, Emma Wesley, Ian R. Daniels, Nishanthi Silva, Melanie Osborne, Nicholas A. Kennedy, James R. Goodhand, Tariq Ahmad
Summary: The study found that patients with IBD have an increased risk of developing CRC compared to the general population, and the incidence of IBD-associated CRC has remained stable over the past 20 years. However, two-thirds of patients eligible for colonoscopic surveillance missed opportunities to diagnose CRC, indicating that surveillance programs lack comprehensive and fully integrated recall systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Andromachi Kotsafti, Matteo Fassan, Francesco Cavallin, Valentina Angerilli, Luca Saadeh, Matteo Cagol, Rita Alfieri, Pierluigi Pilati, Carlo Castoro, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa
Summary: This study found that immune marker expression, oncogene status, and intra- and peritumoral immune infiltrating cells are associated with lymph node metastasis in patients with esophageal adenocarcinoma. These results suggest that immune surveillance failure is the key driver of lymph node metastasis.
Article
Gastroenterology & Hepatology
Linda C. Cummings, Tzuyung Doug Kou, Amitabh Chak, Mark D. Schluchter, Seunghee Margevicius, Gregory S. Cooper
Summary: This study aimed to refine previous analysis by evaluating surveillance through serial endoscopy before EAC diagnosis and assessing its association with stage and survival. Sustained endoscopy was associated with earlier stage and improved survival, supporting the role of sustained surveillance in early detection of EAC.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Jessie R. Elliott, Sheraz Markar, Fredrik Klevebro, Asif Johar, Lucas Goense, Pernilla Lagergren, Giovanni Zaninotto, Richard I. van Hillegersberg, Mark van Berge Henegouwen, Magnus B. Nilsson, George V. Hanna, John Reynolds
Summary: Regular surveillance after curative surgery for esophageal cancer has a significant impact on the recurrence pattern, treatment, survival, and quality of life. Intensive surveillance reduces symptomatic recurrence and increases tumor-directed therapy, particularly in patients with early-stage disease or favorable pathological stage. No overall survival benefit was observed, but improved survival was seen in select patient cohorts.
Article
Surgery
Yuto Shimamura, Yugo Iwaya, Ryosuke Kobayashi, Enrique Rodriguez de Santiago, Niroshan Muwanwella, Spiro Raftopoulos, Jeffrey D. Mosko, Gary R. May, Gabor Kandel, Paul Kortan, Norman Marcon, Christopher W. Teshima
Summary: The study identified predictors of failure to achieve complete eradication of neoplasia and complete eradication of intestinal metaplasia in patients with Barrett's esophagus related high-grade dysplasia and early esophageal adenocarcinoma. Long-segment Barrett's esophagus and other clinical variables were associated with failure to achieve complete eradication. Patients with these predictors should be considered for a more intensive endoscopic treatment approach at expert centers.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Julie A. Webster, Alain Wuethrich, Karthik B. Shanmugasundaram, Renee S. Richards, Wioleta M. Zelek, Alok K. Shah, Louisa G. Gordon, Bradley J. Kendall, Gunter Hartel, B. Paul Morgan, Matt Trau, Michelle M. Hill
Summary: This study developed the technology of the microfluidic EndoScreen chip and validated the blood biomarker JAC-C9 for early detection of esophageal adenocarcinoma (EAC). The use of blood biomarkers JAC-C9 and total C9 in addition to clinical risk factors improved EAC prediction in a test cohort, suggesting the potential for a simple blood test to help prioritize patients for endoscopic evaluation. Future work will expand the panel of markers on the EndoScreen chip to enable population screening and early diagnosis of EAC.
Article
Gastroenterology & Hepatology
Jill Tinmouth, Deepak Swain, Katherine Chorneyko, Vicki Lee, Barbara Bowes, Yingzi Li, Julia Gao, David Morgan
Summary: This study developed and validated an NLP algorithm to identify colorectal adenomas and report ADR at the population level in Ontario, Canada. The algorithm showed high sensitivity and specificity in identifying adenomas, and it was accurately used to measure ADR at the system level.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Hirofumi Abe, Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Hiroya Sakaguchi, Tatsuya Nakai, Nobuaki Ikezawa, Chise Ueda, Satoshi Urakami, Yuzo Kodama
Summary: This study aimed to determine the proportion of patients with missed esophageal motility disorders during endoscopy and their clinical characteristics. Retrospective analysis revealed that 15% of esophageal motility disorders were missed during endoscopy. Non-dilated esophagus, the presence of epiphrenic diverticulum, the use of transnasal endoscopy, and the combined use of esophagram were identified as independent predictors of missed esophageal motility disorders.
Article
Gastroenterology & Hepatology
Sachin Wani, Dag Holmberg, Giola Santoni, Joonas H. Kauppila, Martti Farkkila, My von Euler-Chelpin, Nicholas J. Shaheen, Jesper Lagergren
Summary: A significant number of esophageal adenocarcinoma cases are diagnosed within a year after an ostensibly negative upper endoscopy in patients with newly diagnosed Barrett's esophagus. Interventions to improve detection rates and reduce post-endoscopy esophageal adenocarcinoma and neoplasia are needed.
Article
Surgery
Matthieu Antoine, Usha Krishnan, Michael Manfredi, Julija Cervinskiene, Jerome Viala, Julia Brendel, Christos Tzivinikos, Audrey Vanrenterghem, Georges Dimitrov, Bruno Hauser, Noemie Laverdure, Barbara Rohmer, Helene Behal, Audrey Nicolas, Frederic Gottrand
Summary: Esophageal mucosal bridge (EMB) is commonly seen in children with esophageal atresia (EA) and is associated with a history of nasogastric tube feeding and severe gastroesophageal reflux disease. Endoscopic management with electrocoagulation is a safe and effective treatment option.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Immunology
Meritxell Urtecho, Victor D. Torres Roldan, Tarek Nayfeh, Nataly R. Espinoza Suarez, Nischal Ranganath, Priya Sampathkumar, Vineet Chopra, Nasia Safdar, Larry J. Prokop, John C. O'Horo
Summary: A systematic review and meta-analysis compared the complications of midline catheters and peripherally inserted central catheters (PICCs), focusing on catheter-related bloodstream infection (CRBSI) and thrombosis. The results showed that midline catheters were associated with fewer CRBSIs but a higher risk of superficial venous thrombosis compared to PICCs. These findings provide guidance for future cost-benefit analyses and direct comparative trials to better understand the efficacy and risks of midline catheters versus PICCs.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Jomana Madieh, Bashar Hasan, Iman Khamayseh, Alaa Hrizat, Tareq Salah, Tarek Nayfeh, Kamel Gharaibeh, Abdurrahman Hamadah
Summary: This article presents a systematic review and meta-analysis of the complications associated with peripheral infusion of 3% hypertonic saline (3% HTS). The study found that peripheral administration of 3% HTS has a low rate of complications and is considered a safe and possibly preferred option.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Anas Hashem, Mohamed Salah Mohamed, Khaled Alabdullah, Ahmed Elkhapery, Amani Khalouf, Samer Saadi, Tarek Nayfeh, Devesh Rai, Omar Alali, Elissa A. Kinzelman-Vesely, Vishal Parikh, Scott C. Feitell
Summary: This study analyzed and evaluated articles published between January 2000 and July 2022 to identify mortality-predicting factors in patients with CA supported with VA-ECMO. The study found that predictors of mortality include age >65, history of chronic kidney disease, cardiopulmonary resuscitation duration prior to ECMO >40 minutes, initial rhythm being non-shockable, and Sequential Organ Failure Assessment score >14. These findings are important for improving patient survival rates and guiding treatment decisions.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Critical Care Medicine
Anas Hashem, Amani Khalouf, Mohamed Salah Mohamed, Tarek Nayfeh, Ahmed Elkhapery, Mohammad Elbahnasawy, Devesh Rai, Himanshu Deshwal, Scott Feitell, Sudarshan Balla
Summary: Patients with acute heart failure (AHF) exacerbation are at risk for complications when infected with COVID-19. Limited data exists on the clinical outcomes of COVID-19 in AHF patients. This study used a national inpatient sample database to compare AHF patients with and without COVID-19. It found that COVID-19 infection in AHF patients is associated with higher in-hospital mortality, need for mechanical ventilation, septic shock, and AKI, as well as longer hospital stays and higher costs. The study highlights the importance of understanding the impact of COVID-19 on AHF patients. Rating: 9/10
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Nabil Noureddin, Veeral Ajmera, Jaclyn Bergstrom, Richele Bettencourt, Daniel Q. Huang, Harris Siddiqi, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramzan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Rohit Loomba
Summary: MEFIB-Index and MAST-Score, which combine MRI-based biomarkers and blood tests, can predict the risk of hepatic decompensation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Anas Hashem, Amani Khalouf, Mohamed Salah Mohamed, Mahmoud Ismayl, Anthony Kashou, Rody G. Bou Chaaya, Tarek Nayfeh, Devesh Rai, Samian Sulaiman, Sudarshan Balla
Summary: This study used the National Inpatient Sample to evaluate the clinical outcomes of percutaneous closure of ASD after TEER and TMVR procedures. It was found that the rate of percutaneous closure of ASD was higher in TMVR cases and was associated with higher in-hospital mortality and longer hospital stays. Further clinical trials are needed to identify patients who would benefit from closure of iatrogenic ASD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Nabil Noureddin, Veeral Ajmera, Maral Amangurbanova, Ricki Bettencourt, Emily Truong, Tolga Gidener, Harris Siddiqi, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Masato Yoneda, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Alina M. Allen, Mazen Noureddin, Rohit Loomba
Summary: The presence of type 2 diabetes in patients with NAFLD is associated with a significantly higher risk of hepatic decompensation and hepatocellular carcinoma.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Khaled Alabdallah, Tarek Nayfeh, Samer Saadi, Shazia Aziz, Mohammad Aldiabat, Edward Wilson Grandin, Arthur R. Garan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sung Won Lee, Daniel Q. Huang, Ricki Bettencourt, Veeral Ajmera, Monica Tincopa, Nabil Noureddin, Maral Amangurbanova, Harris Siddiqi, Egbert Madamba, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Masato Yoneda, Ramzan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Rohit Loomba
Summary: Low liver fat content in patients with NASH-related significant fibrosis and cirrhosis is associated with an increase in hepatic decompensation, HCC, and mortality.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cardiac & Cardiovascular Systems
Anas Hashem, Amani Khalouf, Ankit Agrawal, Mohamad Salah Mohamad, Tarek Nayfeh, Anthony Kashou, Rody G. Bou Chaaya, Devesh Rai, Basil Verghese, Stephen H. Little, Andrew Goldsweig, Srihari Naidu, Sachin S. Goel
Summary: This study evaluated the feasibility, safety, and clinical outcomes of intracardiac echocardiography (ICE) guided mitral transcatheter edge-to-edge repair (mTEER) procedure. The results showed no significant differences in in-hospital mortality, complications, and hospital costs compared to transesophageal echocardiography (TEE) guided mTEER.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Meeting Abstract
Gastroenterology & Hepatology
Nabil Noureddin, Daniel Huang, Richele Bettencourt, Harris Siddiqi, Abdul Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Emily Truong, Tolga Gidener, Alina M. Allen, Mazen Noureddin, Veeral Ajmera, Rohit Loomba
Meeting Abstract
Gastroenterology & Hepatology
Karim Osman, Tarek Nayfeh, Judy Alrukby, Neev N. Mehta, Asahi Hoque, Carol Spencer, Lina Elkhabiry, Rowan Elhamamy
Meeting Abstract
Gastroenterology & Hepatology
Karim Osman, Tarek Nayfeh, Neev N. Mehta, Carol Spencer, Anastasia Naritsin, Lina Elkhabiry, Rowan Elhamamy
Meeting Abstract
Gastroenterology & Hepatology
Daniel Huang, Nabil Noureddin, Veeral Ajmera, Maral Amangurbanova, Richele Bettencourt, Emily Truong, Tolga Gidener, Harris Siddiqi, Tarek Nayfeh, Abdul Majzoub, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Mazen Noureddin, Alina M. Allen, Rohit Loomba
Meeting Abstract
Gastroenterology & Hepatology
Sung Won Lee, Daniel Huang, Veeral Ajmera, Monica Tincopa, Jaclyn Bergstrom, Nabil Noureddin, Maral Amangurbanova, Harris Siddiqi, Egbert Madamba, Abdul Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Mazen Noureddin, Rohit Loomba
JOURNAL OF HEPATOLOGY
(2023)
