Precision oncology for breast cancer through clinical trials

THE MOLECULAR ANALYSIS FOR THERAPY CHOICE (NCI-MATCH) TRIAL: LESSONS for GENOMIC TRIAL DESIGN

(2020) Keith T Flaherty et al.   JNCI-Journal of the National Cancer Institute

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

(2019) Yi-Zhou Jiang et al.   CANCER CELL

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

(2019) Leticia De Mattos-Arruda et al.   Cell Reports

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

(2019) Michael Olivier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systematic Functional Annotation of Somatic Mutations in Cancer

(2018) Patrick Kwok-Shing Ng et al.   CANCER CELL

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

(2018) Ashton C. Berger et al.   CANCER CELL

Crosstalk between cancer and the neuro-immune system

(2018) Nyanbol Kuol et al.   JOURNAL OF NEUROIMMUNOLOGY

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Molecular heterogeneity in breast cancer: State of the science and implications for patient care

(2017) Rachel E. Ellsworth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

(2017) David Brown et al.   Nature Communications

Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

(2017) Eirini Pectasides et al.   Cancer Discovery

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Perspective: The precision-oncology illusion

(2016) Vinay Prasad   NATURE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Functional annotation of rare gene aberration drivers of pancreatic cancer

(2016) Yiu Huen Tsang et al.   Nature Communications

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

(2015) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

The Master Protocol Concept

(2015) Mary W. Redman et al.   SEMINARS IN ONCOLOGY

The AURORA initiative for metastatic breast cancer

(2014) D Zardavas et al.   BRITISH JOURNAL OF CANCER

Molecular Pathways: Myeloid Complicity in Cancer

(2014) I. M. Stromnes et al.   CLINICAL CANCER RESEARCH

Genome-wide transcriptome profiling of homologous recombination DNA repair

(2014) Guang Peng et al.   Nature Communications

Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry

(2013) Hatem Soliman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Pathologic Complete Response Predicts Recurrence-Free Survival More Effectively by Cancer Subset: Results From the I-SPY 1 TRIAL—CALGB 150007/150012, ACRIN 6657

(2012) Laura J. Esserman et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

(2009) AD Barker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE