Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 57, Issue 4, Pages 462-466Publisher
SPRINGER
DOI: 10.1007/s10593-021-02924-4
Keywords
1,2,4-triazines; antiviral activity; ipso substitution; nucleophilic hydrogen substitution; solvent-free reactions; vaccinia virus
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Funding
- Russian Science Foundation [19-73-10144]
- Russian Foundation for Basic Research [19-53-55002]
- National Natural Science Foundation of China [81961138011]
- Beijing Natural Science Foundation [7192106]
- Russian Science Foundation [19-73-10144] Funding Source: Russian Science Foundation
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Newly synthesized 3-(pyridin-4-yl)-1,2,4-triazine compounds and their 4-nitrophenyl analogs show promising characteristics in relation to antiviral activity, particularly when compared to the antiviral drug Cidofovir.
Using atom-economical approaches, new representatives of 3-(pyridin-4-yl)-1,2,4-triazines and their 4-nitrophenyl analogs were obtained, and their activity in relation to the vaccinia virus was studied. The new compounds have shown promising characteristics, in particular, in comparison to the antiviral drug Cidofovir.
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