Exploring the human lacrimal gland using organoids and single-cell sequencing

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

(2020) Maarten H. Geurts et al.   Cell Stem Cell

Establishment of long-term serum-free culture for lacrimal gland stem cells aiming at lacrimal gland repair

(2020) Sa Xiao et al.   Stem Cell Research & Therapy

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study

(2019) Sushma Kalmodia et al.   Scientific Reports

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

(2019) Hui Lin et al.   Translational Vision Science & Technology

Diagnosis and genetics of alacrima

(2018) J. Adams et al.   CLINICAL GENETICS

Development of lacrimal gland spheroids for lacrimal gland tissue regeneration

(2018) Isobel Massie et al.   Journal of Tissue Engineering and Regenerative Medicine

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

(2018) Josip S Herman et al.   NATURE METHODS

Histatins, wound healing, and cell migration

(2018) P Torres et al.   ORAL DISEASES

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

The Role of BPIFA1 in Upper Airway Microbial Infections and Correlated Diseases

(2018) Yung-An Tsou et al.   Biomed Research International

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Investigation of the global protein content from healthy human tears

(2018) Marianne Dor et al.   EXPERIMENTAL EYE RESEARCH

The Human Cell Atlas

(2017) Aviv Regev et al.   eLife

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland

(2016) Robin R. Hodges et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

(2016) Martti Maimets et al.   Stem Cell Reports

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Sjögren syndrome

(2016) Pilar Brito-Zerón et al.   Nature Reviews Disease Primers

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients

(2016) Natarajan Perumal et al.   Scientific Reports

Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif

(2015) Chris D. St. Laurent et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium

(2015) Xiao Wen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Efficient genetic engineering of human intestinal organoids using electroporation

(2015) Masayuki Fujii et al.   Nature Protocols

Retinoic acid and the ocular surface

(2015) Chameen Samarawickrama et al.   SURVEY OF OPHTHALMOLOGY

Necessity of Smad4 for the normal development of the mouse lacrimal gland

(2014) Ying Liu et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

A Cleavage-potentiated Fragment of Tear Lacritin Is Bactericidal

(2014) Robert L. McKown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and biochemical characterization of recombinant human epididymis protein 4

(2014) Ling Hua et al.   PROTEIN EXPRESSION AND PURIFICATION

Diadenosine tetraphosphate contributes to carbachol-induced tear secretion

(2014) Begoña Fonseca et al.   Purinergic Signalling

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

(2013) Masatoshi Hirayama et al.   Nature Communications

Establishing Human Lacrimal Gland Cultures with Secretory Function

(2012) Shubha Tiwari et al.   PLoS One

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases

(2009) Darlene A. Dartt   PROGRESS IN RETINAL AND EYE RESEARCH

Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line

(2008) Alan L. Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antimicrobial properties of lactoferrin

(2008) H JENSSEN et al.   BIOCHIMIE