Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

(2019) Mohammad Arifuzzaman et al.   Science Advances

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

(2019) Dustin P. Green et al.   NEURON

Beta-defensins are proinflammatory pruritogens that activate Mrgprs

(2019) Li Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cis-Regulatory Atlas of the Mouse Immune System

(2019) Hideyuki Yoshida et al.   CELL

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

(2019) Jonathan A. Cohen et al.   CELL

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

(2019) Priyanka Pundir et al.   Cell Host & Microbe

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

(2019) Nadine Serhan et al.   NATURE IMMUNOLOGY

Charting the cis-regulome of activated B cells by coupling structural and functional genomics

(2019) Virendra K. Chaudhri et al.   NATURE IMMUNOLOGY

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain

(2018) Changming Wang et al.   FASEB JOURNAL

Botulinum toxin blocks mast cells and prevents rosacea like inflammation

(2018) Jae Eun Choi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein–coupled receptor D

(2018) Tereza Bautzova et al.   Science Signaling

LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2

(2017) Yangyang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers

(2017) Hélène Beaudry et al.   PAIN

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

(2016) Hariharan Subramanian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

(2016) Daniel F Dwyer et al.   NATURE IMMUNOLOGY

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity

(2015) Sakeen W. Kashem et al.   IMMUNITY

Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs

(2015) Ana Reynders et al.   Cell Reports

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

(2015) Jan Dudeck et al.   Cell Reports

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

(2014) Lintao Qu et al.   BRAIN

Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors

(2014) Srinivasan Tupal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mast Cells Are Key Mediators of Cathelicidin-Initiated Skin Inflammation in Rosacea

(2014) Yumiko Muto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Langerhans cells regulate cutaneous innervation density and mechanical sensitivity in mouse footpad

(2014) Argenia L.N. Doss et al.   NEUROSCIENCE LETTERS

Diversification and Specialization of Touch Receptors in Skin

(2014) D. M. Owens et al.   Cold Spring Harbor Perspectives in Medicine

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency

(2012) Tatsuyoshi Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

(2011) Anne Dudeck et al.   IMMUNITY

Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells

(2011) Hariharan Subramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Assembly Mechanism for Heteromeric Kainate Receptors

(2011) Janesh Kumar et al.   NEURON

Acute Ablation of Langerhans Cells Enhances Skin Immune Responses

(2010) A. Bobr et al.   JOURNAL OF IMMUNOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity

(2010) G. Scherrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors

(2009) K. K. Rau et al.   JOURNAL OF NEUROSCIENCE

vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol

(2009) Anneleen Schallier et al.   NEUROCHEMISTRY INTERNATIONAL

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Langerhans cell function from Langerhans cell ablation models

(2008) Daniel H. Kaplan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Langerhans Cells Are Not Required for Efficient Skin Graft Rejection

(2008) Jagdeep S. Obhrai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY