Psychedelic-inspired drug discovery using an engineered biosensor

A genetically encoded sensor for measuring serotonin dynamics

(2021) Jinxia Wan et al.   NATURE NEUROSCIENCE

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure–Activity Relationship Studies

(2020) Lee E. Dunlap et al.   JOURNAL OF MEDICINAL CHEMISTRY

A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses

(2020) Tingying Chi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species

(2020) Adam L. Halberstadt et al.   NEUROPHARMACOLOGY

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning

(2020) Elizabeth K. Unger et al.   CELL

A non-hallucinogenic psychedelic analogue with therapeutic potential

(2020) Lindsay P. Cameron et al.   NATURE

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

(2019) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR

(2019) Robert J. Tombari et al.   ACS Chemical Biology

Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine

(2018) Lee E. Dunlap et al.   ACS Chemical Neuroscience

Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression

(2018) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems

(2018) Jing Ren et al.   CELL

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

(2018) Katrin H Preller et al.   eLife

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Serotonin modulates spike probability in the axon initial segment through HCN channels

(2016) Kwang Woo Ko et al.   NATURE NEUROSCIENCE

De novo synaptogenesis induced by GABA in the developing mouse cortex

(2016) Won Chan Oh et al.   SCIENCE

Biased Agonism at G Protein-Coupled Receptors: The Promise and the Challenges-A Medicinal Chemistry Perspective

(2014) Jeremy Shonberg et al.   MEDICINAL RESEARCH REVIEWS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Animal Models of Serotonergic Psychedelics

(2012) James B. Hanks et al.   ACS Chemical Neuroscience

Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number

(2012) Hyung-Bae Kwon et al.   NATURE NEUROSCIENCE

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Characterization of 3,4-Methylenedioxymethamphetamine (MDMA) Enantiomers In Vitro and in the MPTP-Lesioned Primate: R-MDMA Reduces Severity of Dyskinesia, Whereas S-MDMA Extends Duration of ON-Time

(2011) P. Huot et al.   JOURNAL OF NEUROSCIENCE

Circular polymerase extension cloning for high-throughput cloning of complex and combinatorial DNA libraries

(2011) Jiayuan Quan et al.   Nature Protocols

Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a  -Arrestin2/Src/Akt Signaling Complex In Vivo

(2010) C. L. Schmid et al.   JOURNAL OF NEUROSCIENCE

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Microwave-promoted mono-N-alkylation of aromatic amines in water: a new efficient and green method for an old and problematic reaction

(2009) Giovanni Marzaro et al.   GREEN CHEMISTRY

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

(2008) Didier Cussac et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Agonist-directed signaling of the serotonin 2A receptor depends on  -arrestin-2 interactions in vivo

(2008) C. L. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA