Article
Infectious Diseases
Carolin E. M. Jakob, Ujjwal Mukund Mahajan, Marcus Oswald, Melanie Stecher, Maximilian Schons, Julia Mayerle, Siegbert Rieg, Mathias Pletz, Uta Merle, Kai Wille, Stefan Borgmann, Christoph D. Spinner, Sebastian Dolff, Clemens Scherer, Lisa Pilgram, Maria Ruethrich, Frank Hanses, Martin Hower, Richard Strauss, Steffen Massberg, Ahmet Gorkem Er, Norma Jung, Joerg Janne Vehreschild, Hans Stubbe, Lukas Tometten, Rainer Koenig
Summary: This study developed a machine learning-based predictor model and a clinical score for identifying patients at risk of progressing to advanced COVID-19, with a focus on better prioritizing patients in need for hospitalization. The predictor model included variables such as temperature, age, body mass index, smoking habit, pulmonary involvement, inflammation markers, and acute kidney injury to predict the disease severity of COVID-19 patients.
Article
Psychiatry
Risha Govind, Daniela Fonseca de Freitas, Megan Pritchard, Richard D. Hayes, James H. MacCabe
Summary: During the COVID-19 pandemic, patients with schizophrenia-spectrum disorders receiving clozapine treatment had a higher risk of COVID-19 infection, although the risk was attenuated after adjusting for certain confounders. These findings provide support for the hypothesis that clozapine treatment is associated with an increased risk of COVID-19 infection, and further research in other populations is needed to confirm this association.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Virology
Ranran Xu, Junwei Cui, Liu Hu, Yiru Wang, Tao Wang, Dawei Ye, Yongman Lv, Qingquan Liu
Summary: This study aims to identify predictors of critical cases among COVID-19 patients and develop a simple-to-use nomogram for clinical utility. The study found that age, comorbid diseases, neutrophil-to-lymphocyte ratio, d-dimer, C-reactive protein, and platelet count were independent predictors of progression to critical cases in COVID-19 patients. The nomogram demonstrated good discrimination and calibration, and external validations supported its clinical relevance.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biology
Riku Klen, Ivan A. Huespe, Felipe Anibal Gregalio, Antonio Lalueza Lalueza Blanco, MiguelPedrera Jimenez, Noelia Garcia Barrio, Pascual Ruben Valdez, Matias A. Mirofsky, Bruno Boietti, Ricardo Gomez-Huelgas, Jose Manuel Casas-Rojo, Juan Miguel Anton-Santos, Javier Alberto Pollan, David Gomez-Varela
Summary: This study developed an early warning score system (COEWS) that can automatically calculate the risk of complications in COVID-19 patients within the next 24-48 hours based on widely available laboratory parameters. The COEWS model includes complete blood count, blood glucose, and oxygen saturation features, and it can predict the need for mechanical ventilation or death in the next 48 hours. The COEWS score showed high accuracy and reliability in external validation, positioning it as a valuable tool in guiding clinical decisions and improving patient care in the future pandemic waves.
Article
Medicine, Research & Experimental
Ghodsiyeh Azarkar, Freshteh Osmani
Summary: The mortality rate of inpatients with COVID-19 was 17.4%, and patients with lower lymphocyte counts, platelet counts, C-reactive protein levels, and comorbidities may have a higher risk of death.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Infectious Diseases
Yi Zhou, Qiao Yang, Jun Ye, Xiaocheng Wu, Xianhua Hou, Yimei Feng, Bangyu Luo, Jixi Li, Guangrong Yang, Lingchen Li, Xiu Yang, Bin Wang, Songtao Zhao, Li Li, Qi Li, Zhi Xu, Hao Wu, Jianguo Sun
Summary: A retrospective study was conducted on 103 COVID-19 patients with cancer to analyze their clinical features and determine death outcome related risk factors. The study found significant differences in clinical features and laboratory results between severe and non-severe patients, with NLR and CRP identified as predictors of death outcome.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Aristotelis Tsiakalos, Panayiotis D. Ziakas, Eleni Polyzou, Georgios Schinas, Karolina Akinosoglou
Summary: In this retrospective study, the potential benefit of fluvoxamine on early-stage COVID-19 patients was explored. It was found that adding fluvoxamine to the treatment of symptomatic COVID-19 patients in the early stages could reduce the risk of clinical deterioration. This study provides a basis for further investigation into the low-cost, low-toxicity option of fluvoxamine in the community setting.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Palmisano, Chiara Gnasso, Alberto Cereda, Davide Vignale, Riccardo Leone, Valeria Nicoletti, Simone Barbieri, Marco Toselli, Francesco Giannini, Marco Loffi, Gianluigi Patelli, Alberto Monello, Gianmarco Iannopollo, Davide Ippolito, Elisabetta Maria Mancini, Gianluca Pontone, Luigi Vignali, Elisa Scarnecchia, Mario Iannaccone, Lucio Baffoni, Massimiliano Spernadio, Caterina Chiara de Carlini, Sandro Sironi, Claudio Rapezzi, Antonio Esposito
Summary: This study aims to evaluate the value of opportunistic biomarkers derived from chest CT at hospital admission of COVID-19 patients for the phenotypization of high-risk patients. The analysis of chest CT results from 1845 consecutive COVID-19 patients revealed that opportunistic data related to treatment and outcome (such as atherosclerosis, liver steatosis, myosteatosis, and osteoporosis) were more prevalent in high-risk patients. The combination of clinical and CT variables in a multivariate model improved the prediction of non-critical pneumonia and patient death.
EUROPEAN RADIOLOGY
(2023)
Article
Infectious Diseases
Peipei Hu, Mengmeng Ma, Qinlong Jing, Yu Ma, Lin Gan, Yan Chen, Jundi Liu, Dahu Wang, Zhoubin Zhang, Dingmei Zhang
Summary: The study found that children may be less susceptible to COVID-19, while close contacts with frequent contact with patients and those exposed to patients with cough symptoms have a higher risk of infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Yu Shionoya, Toshibumi Taniguchi, Hajime Kasai, Noriko Sakuma, Shun Imai, Kohei Shikano, Shin Takayanagi, Misuzu Yahaba, Taka-aki Nakada, Hidetoshi Igari, Seiichiro Sakao, Takuji Suzuki
Summary: This study suggests that administering steroids before antiviral drugs in patients with COVID-19 pneumonia may worsen disease severity. Initiating antiviral drugs first could be safer when considering the use of steroids soon after symptom onset.
Article
Multidisciplinary Sciences
Nathanael Fillmore, Steven Bell, Ciyue Shen, Vinh Nguyen, Jennifer La, Maureen Dubreuil, Judith Strymish, Mary Brophy, Gautam Mehta, Hao Wu, Judy Lieberman, Nhan Do, Chris Sander
Summary: The study suggests that Disulfiram may reduce the risk of SARS-CoV-2 infection and severity of COVID-19. Further clinical trials are needed to assess its therapeutic effects.
Article
Medicine, General & Internal
Brenda M. Juan Guardela, Jiehuan Sun, Tong Zhang, Bing Xu, Joseph Balnis, Yong Huang, Shwu-Fan Ma, Philip L. Molyneaux, Toby M. Maher, Imre Noth, Gaetane Michaud, Ariel Jaitovich, Jose D. Herazo-Maya
Summary: Blood transcript levels of 50 genes can be used to predict outcomes in COVID-19 and IPF patients, suggesting common immune responses in both diseases. The 50-gene risk profiles are effective in distinguishing severe from mild COVID-19 and predicting disease progression and mortality.
Article
Virology
Maaike van Gerwen, Mathilda Alsen, Christine Little, Joshua Barlow, Eric Genden, Leonard Naymagon, Douglas Tremblay
Summary: Male gender, age over 60, congestive heart failure, dementia, and having more than two comorbidities are associated with a higher risk of severe outcomes, hospitalization, mechanical ventilation, and death among patients with COVID-19. These patients should be closely monitored.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Fen Xiao, Ying-Chu Zhou, Mei-Biao Zhang, Dong Chen, Shao-Lin Peng, Hao-Neng Tang, Long Li, Chen-Yi Tang, Ji-Yang Liu, Bo Li, Hou-De Zhou
Summary: This study aimed to assess the use of blood glucose control as predictors for the severity of COVID-19 and to improve the management of diabetic patients with COVID-19. The results showed that admission hyperglycemia and blood glucose deterioration were risk factors for severe COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, General & Internal
Renin Chang, Thomas Yen-Ting Chen, Shiow-Ing Wang, Yao-Min Hung, Hui-Yuan Chen, Cheng-Chung James Wei
Summary: This retrospective cohort study reveals that there is a significant association between COVID-19 and the risk of autoimmune diseases. However, further research is needed to replicate these findings in an independent dataset and understand the underlying mechanisms.
Article
Geochemistry & Geophysics
Shikai Wei, Haichun Guo, Jiantao Cao, Guodong Jia, Mingzhi Chen, Zhiguo Rao
Summary: This study investigates the origin of brGDGTs in the Shiwangutian peatland in southern China and finds that they are primarily generated in-situ. Similar conclusions are drawn from comparisons of globally-distributed surface peat sediments and surface soils. Additionally, the origin of brGDGTs may vary in specific environments.
ORGANIC GEOCHEMISTRY
(2022)
Article
Agronomy
Hailing Li, Maohong Wei, Longwei Dong, Weigang Hu, Junlan Xiong, Ying Sun, Yuan Sun, Shuran Yao, Haiyang Gong, Yahui Zhang, Qingqing Hou, Xiaoting Wang, Shubin Xie, Liang Zhang, Muhammad Adnan Akram, Zhiguo Rao, A. Allan Degen, Karl J. Niklas, Jinzhi Ran, Jian-sheng Ye, Jianming Deng
Summary: This study compares global-scale patterns and drivers of leaf and ecosystem water use efficiency (WUE), revealing almost opposite trends in response to abiotic factors. Leaf intrinsic WUE is highest in arid regions and lowest in humid regions, while ecosystem WUE is lowest in arid regions and highest in humid regions. Phylogeny significantly affects leaf intrinsic WUE, while leaf area index is the most robust predictor of ecosystem WUE.
AGRICULTURAL AND FOREST METEOROLOGY
(2022)
Article
Geochemistry & Geophysics
Zhiguo Rao, Haichun Guo, Shikai Wei, Jiantao Cao, Guodong Jia
Summary: This study compares surface peat samples from peatlands with different environmental conditions in China, and finds that water conditions have a clear influence on the molecular distribution of peat brGDGTs. This indicates that factors other than temperature can affect the interpretation of brGDGTs as temperature indicators.
Article
Oncology
Ziyue Zhang, Yi Dong, Bin Wu, Yingge Li, Zehui Liu, Zheming Liu, Yanjun Gao, Likun Gao, Qibin Song, Zhongliang Zheng, Yi Yao
Summary: The study revealed that radiation can activate CAFs, which in turn, promote the proliferation, migration, radiotherapy resistance, and tumorigenesis of lung cancer cells. The findings suggest that inhibiting the activation of CAFs may be a crucial way to enhance the efficacy of clinical radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Yi Dong, Lina Yi, Qibin Song, Yi Yao
Summary: This study investigates the relationship between lung adenocarcinoma (LUAD) and pyroptosis, a new form of programmed cell death. A clinical model based on pyroptosis-related genes was developed and shown to accurately predict the prognosis of LUAD patients. The model was also associated with tumor microenvironment, tumor mutational burden, and drug sensitivity.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Songjiang He, Shi Zhang, Yi Yao, Bin Xu, Zhili Niu, Fuben Liao, Jie Wu, Qibin Song, Minglun Li, Zheming Liu
Summary: Glutamine metabolism is significant in the clinical outcomes of patients with pan-cancer and is closely associated with several hallmarks of a malignant tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingge Li, Jie Chen, Bin Wang, Ziwen Xu, Ci Wu, Junfeng Ma, Qibin Song, Qing Geng, Jinming Yu, Huadong Pei, Yi Yao
Summary: This study aims to investigate the regulatory mechanisms of nucleotide de novo synthesis and drug resistance. By analyzing ChIP-Seq data, RNA sequencing, and luciferase-based promoter assay, the researchers identified FOXK2 as a key regulator of nucleotide de novo synthesis. FOXK2 directly regulates the expression of nucleotide synthetic genes, promoting tumor growth and cancer cell resistance to chemotherapy. In clinical analysis, elevated expression of FOXK2 is associated with increased nucleotide synthetic gene expression and poor prognosis in hepatocellular carcinoma patients.
DRUG RESISTANCE UPDATES
(2023)
Article
Meteorology & Atmospheric Sciences
Zhongli Liu, Xinping Zhang, Zhuoyong Xiao, Xinguang He, Zhiguo Rao, Huade Guan
Summary: The stable oxygen isotope composition of precipitation in southern China is studied as a valuable proxy for climatic conditions. The results suggest a significant negative correlation between summer precipitation and the stable isotope composition of precipitation in the Dongting Lake basin. Additionally, local factors such as precipitation amount and large-scale circulation play important roles in determining the oxygen isotope composition.
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2023)
Article
Geography, Physical
Shikai Wei, Zhiguo Rao, Jiantao Cao, Guodong Jia, Yunxia Li, Haichun Guo, Zixian Feng, Kaiyue Guang, Qianqian Qin, Yiping Tian, Jiayan Li, Siqi Li, Mingzhi Chen
Summary: Recent syntheses of marine paleoclimate records have shown a long-term Holocene warming trend, especially in mean annual temperature (MAT), which differs from terrestrial records on continental and global scales. A record of branched glycerol dialkyl glycerol tetraethers (brGDGTs) from the Shiwangutian (SWGT) peatland in China supports this trend and demonstrates the potential of brGDGTs as a local environmental change indicator. Comparative studies from peatlands across China further highlight the complexity of brGDGTs as a climate indicator and emphasize the need for more research in this area.
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shuting Xiao, Yi Yao, Shuilin Liao, Bin Xu, Xue Li, Yuxiao Zhang, Lei Zhang, Qiang Chen, Haoneng Tang, Qibin Song, Ming Dong
Summary: Researchers have developed an EV-MPDS system based on FRET signals, which allows convenient diagnosis of lung cancer without the need for EV extraction and purification. In clinical samples, this system demonstrated improved accuracy and sensitivity compared to the ELISA detection method, with early screening accuracy further enhanced through machine learning analysis of five biomarkers.
Article
Oncology
Zheming Liu, Songjiang He, Zhou Huang, Jiahui Liu, Yiping Gong, Yi Yao, Xue Zhang
Summary: Drug resistance is a major challenge in immunotherapy for triple negative breast cancer patients. This study investigated the mechanisms of drug resistance using single-cell RNA sequencing data and TCGA transcriptomic data. CD8+ NKT cells and classical monocytes were found to play vital roles in the immunotherapy response, and DUSP1 was identified as a potential key factor in immunotherapy resistance.
Review
Oncology
Yingmei Wen, Yi Dong, Lina Yi, Guifang Yang, Mengxia Xiao, Qingqing Li, Chen Zhao, Dafu Ye, Yi Yao
Summary: This study reports the treatment course of a patient with advanced pulmonary sarcomatoid carcinoma. The patient initially received treatment with anlotinib, followed by the addition of Pembrolizumab, leading to partial response. The patient survived for 14 months with no significant adverse reactions during treatment. Genomic analysis revealed mutations associated with treatment efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jie Chen, Siqi Yang, Yingge Li, Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei
Summary: The de novo nucleotide biosynthetic pathway is a highly conserved and crucial biochemical pathway found in almost all organisms. Dysregulation of this pathway has been linked to the development of many human diseases, including cancer. In this review, the authors provide a comprehensive overview of the pathway, its regulatory mechanisms, its role in tumorigenesis, and potential targeting opportunities.
Article
Oncology
Zixin Guo, Liwen Hu, Qingwen Wang, Yujin Wang, Xiao-Ping Liu, Chen Chen, Sheng Li, Weidong Hu
Summary: This study explores lactate-related genes (LRGs) in lung adenocarcinoma (LUAD) using multiple methods. Lactate subtypes are found to be independent prognostic biomarkers and closely related to the tumor microenvironment (TME). Comprehensive evaluation of lactate subtypes helps understand TME infiltration characteristics and guide immunotherapy strategies.
Article
Geography, Physical
Lidan Liu, Hengyu Liu, Zhiguo Rao, Chao Huang, Lin Zhao, Yunxia Li
Summary: By analyzing the topsoil phytolith assemblages and establishing a modern soil phytolith reference dataset, this study confirms the reliability of phytolith analysis for reconstructing the past vegetation in the mid-subtropical zone of China. The phytolith-based Holocene vegetation types are consistent with pollen-based reconstructions, and the phytolith analysis provides additional information on understory herbaceous plants and grasses.
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2023)