Review
Pharmacology & Pharmacy
Shiqi Li, Hui Zeng, Junli Fan, Fubing Wang, Chen Xu, Yirong Li, Jiancheng Tu, Kenneth P. Nephew, Xinghua Long
Summary: Cancer cells reprogram their metabolism to promote growth, with altered metabolic pathways adapting to the uncontrolled proliferation of cancer cells. Glucose and glutamine are important nutrients for cancer cell growth, with increased glucose uptake and lactate production known as the Warburg effect. Glutamine metabolism also plays a crucial role, providing carbon and nitrogen sources for cancer cell growth while compensating for the reduction in oxidative phosphorylation. Targeting the metabolic differences between tumor and normal cells may lead to promising anticancer strategies, with glutamine metabolic compartments emerging as potential treatment targets for breast cancer and drug resistance.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Qi Shen, Rui Wang, Xinling Liu, Ping Song, Mingzhu Zheng, Xiaomin Ren, Jingang Ma, Zhong Lu, Jiaqiu Li
Summary: Based on recent research, this study explores the regulatory mechanism of glutamine metabolism in cancer cells, focusing on the activation of super-enhancers and their relationship to the transcription factor HSF1. The study identifies an HSF1-mediated super enhancer, lncRNA-LINC00857, which promotes the expression of SLC1A5/ASCT2 and facilitates glutamine transport. Targeting the HSF1/LINC00857/ANXA11 axis may provide a valuable therapeutic strategy against colorectal cancer.
Review
Chemistry, Medicinal
Tyler Sniegowski, Ksenija Korac, Yangzom D. Bhutia, Vadivel Ganapathy
Summary: Glutaminolysis and serine-glycine-one-carbon pathways in cancer cells are reprogrammed and upregulated to support the growth and proliferation of cancer cells. These pathways play crucial roles in the synthesis of purines, pyrimidines, and epigenetic modifications, with methionine being essential for methyl-transfer reactions.
Review
Medicine, General & Internal
Fen Xu, Hong-Liang Jiang, Wei-Wei Feng, Chen Fu, Jiang-Chang Zhou
Summary: Metabolomics research in cancer screening and treatment has gained attention in recent years. It is a popular technique for quantitatively characterizing small molecular compounds in biological cells, tissues, organs, or organisms. Changes in amino acid metabolism in tumors play a crucial role in their growth and metabolism, making the study of amino acid metabolism characteristics particularly important in colorectal cancer.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Chemistry, Multidisciplinary
Xiao Dong, Shu Xia, Shubo Du, Mao-Hua Zhu, Xing Lai, Shao Q. Yao, Hong-Zhuan Chen, Chao Fang
Summary: Cancer immunotherapy is a established therapeutic approach in oncology, but its effectiveness in most cancer patients is still unsatisfactory. The tumor microenvironment, characterized by acidity, oxygen and nutrient deprivation, and immunosuppressive metabolites, can impair the function of tumor-infiltrating immune cells and compromise immunotherapy. Tumor metabolism-rewriting nanomedicines have emerged as an attractive strategy to enhance antitumor immunity by targeting tumor metabolism. This review summarizes the progress in the development of multifunctional tumor metabolism-rewriting nanomedicines and discusses the prospects and challenges in this field.
ACS CENTRAL SCIENCE
(2023)
Article
Genetics & Heredity
Yin-wei Dai, Zhi-kai Wen, Zhi-xuan Wu, Hao-dong Wu, Lin-xi Lv, Cong-zhi Yan, Cong-hui Liu, Zi-qiong Wang, Chen Zheng
Summary: This study established a prognostic model for breast cancer based on amino acid metabolism-related lncRNAs, which can predict the outcome of patients and identify immune and molecular characteristics.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Robert B. Hamanaka, Gokhan M. Mutlu
Summary: Fibrosis is a pathological condition resulting from abnormal wound healing responses, contributing to significant mortality worldwide. Metabolic reprogramming plays a crucial role in the pathogenic phenotype of fibrotic diseases, particularly in myofibroblast differentiation. Understanding metabolic changes and amino acid synthesis is essential for developing novel therapeutic approaches.
Review
Biochemistry & Molecular Biology
Go Woon Kim, Dong Hoon Lee, Yu Hyun Jeon, Jung Yoo, So Yeon Kim, Sang Wu Lee, Ha Young Cho, So Hee Kwon
Summary: Glutamine plays a crucial role in cancer metabolism, with cancer cells consuming excessive amounts for rapid proliferation, especially in poorly vascularized cancers. Glutamine synthetase (GS) is essential in cancer metabolism as the sole enzyme responsible for synthesizing glutamine, which supports nucleotide synthesis. GS exhibits pro-tumoral features by providing glutamine to cancer cells in the tumor microenvironment, enabling cancer cells to maintain sufficient glutamine levels for catabolism, ultimately supporting cancer cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Vivek Anand, Bin Yuan, Fouad El-Dana, Yuanqing Yan, Zoe Arvanitis, Danthasinghe Waduge Badrajee Piyarathna, Nagireddy Putluri, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, V. Lokesh Battula
Summary: This study demonstrates that metabolic stress induces the GD2(+) BCSC phenotype in triple-negative breast cancer (TNBC) and highlights the role of glutamine in this phenotype. Inhibiting glutamine transporters can reduce BCSC characteristics in TNBC cells, suggesting a potential complementary approach to conventional chemotherapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Julio Jose Jimenez-Alonso, Emilio Guillen-Mancina, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: The study evaluated the therapeutic potential of selective amino acid restriction in colon cancer and found that artificial diets based on this restriction can improve survival rates.
Article
Oncology
Xinbo Wang, Yueqing Chen, Xudong Wang, Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu'e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang, Ping Wang
Summary: This study uncovers a SOX2-SLC7A11 regulatory axis that confers resistance to ferroptosis in lung cancer stem-like cells.
Article
Oncology
Lirong Zhai, Xiao Yang, Yuan Cheng, Jianliu Wang
Summary: This study developed a prognostic model related to glutamine metabolism for endometrial cancer (EC) and explored potential targets for cancer treatment.
Article
Biochemistry & Molecular Biology
Abhijit Das, Gregory Gauthier-Coles, Stefan Broer, Caroline D. Rae
Summary: This study examined the cycling of glutamine and alanine in the cerebellum by inhibiting amino acid transporters. The results indicate that the cerebellum has tightly coupled cells and that glutamate/glutamine, as well as alanine cycling, play a major role in this part of the brain.
Article
Chemistry, Multidisciplinary
Hanaa M. Morad, Mohamed M. Abou-Elzahab, Salah Aref, Ahmed M. A. EL-Sokkary
Summary: This study used NMR as a noninvasive diagnostic tool to analyze plasma and urine samples from patients diagnosed with acute lymphoblastic leukemia, acute myeloid leukemia, and breast cancer. The results showed that the metabolite levels in the plasma were higher in cancer patients compared to healthy controls, while the metabolite levels in urine were lower in cancer patients. These findings suggest that H-1 NMR can be a successful and noninvasive tool for the diagnosis of different types of cancer.
Article
Multidisciplinary Sciences
Yoojeong Seo, Joyeon Kang, Tae Il Kim, Chan Gyu Joo
Summary: This study used MRI to investigate the correlation between glutamine uptake and the distribution of glutamine transporters, glutaminase, and CSC markers. The results showed a positive correlation between glutamine uptake and the distribution of ASCT2 and certain CSC markers.
SCIENTIFIC REPORTS
(2022)
