Article
Cell Biology
Meifang Song, Luyuan Ma, Chuan Shen, Wenpeng Liu, Pengfei Zhang, Ranran Bi, Caiyan Zhao
Summary: The key gene identified in causing lenvatinib resistance was PINK1, which maintains mitochondrial structure and function. The FGD5-AS1/miR-5590-3p/PINK1 axis may be a promising strategy to overcome lenvatinib resistance in treatment-negative patients.
CELLULAR SIGNALLING
(2023)
Article
Multidisciplinary Sciences
Wenxin Qi, Qian Liu, Wenjun Fu, Jiaming Shi, Minmin Shi, Songqi Duan, Zhe Li, Shaohua Song, Jiao Wang, Yihao Liu
Summary: This study found that BHLHE40 is highly expressed in pancreatic cancer tissues and is associated with poor prognosis of patients. Further experiments revealed that BHLHE40 may be involved in immunosuppression of pancreatic cancer. Silencing BHLHE40 can inhibit the proliferation, invasion, and apoptosis of pancreatic cancer cells, suggesting that BHLHE40 is a potential therapeutic target for pancreatic cancer.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Yue Yang, Zhibo Sun, Feng Liu, Yuanzhang Bai, Fei Wu
Summary: This study revealed that FGD5-AS1 was downregulated in cartilage tissues of OA patients, while miR-302d-3p was upregulated. It is suggested that FGD5-AS1 may inhibit OA progression by regulating the miR-302d-3p/TGFBR2 axis.
Article
Cell Biology
Qixuan Cai, Xin Zhao, Yanbing Wang, Shuai Li, Jincheng Wang, Zhuoyuan Xin, Fan Li
Summary: The study identified that LINC01614 is significantly upregulated in osteosarcoma tissues and promotes the proliferation and invasion activities of osteosarcoma cells through the miR-520a-3p/SNX3 axis.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Zhang Aichen, Wang Kun, Sun Xiaochun, Tong Lingling
Summary: FGD5-AS1 is markedly up-regulated in ovarian cancer and its high expression is associated with positive local lymph node metastasis and higher T stage in patients. Mechanistically, FGD5-AS1 promotes the proliferation, migration, and invasion of OC cells by targeting miR-142-5p.
Article
Oncology
Wei-Tao Zhang, Ji-Jun Zhang, Quan Shao, Ying-Kai Wang, Jie-Peng Jia, Bo Qian, Xiao-Wen Tian, Wen-Ji Yan
Summary: This study reveals that the upregulated expression of FGD5-AS1 in pancreatic cancer activates the Wnt/β-catenin signaling pathway and promotes cancer cell proliferation, migration, and invasion by suppressing miR-577.
Article
Health Care Sciences & Services
Yi Wang, Yanzhi Zou, Qingmei Zhang, Defu Chen, Lin Lin
Summary: The study found that SBF2-AS1 is highly expressed in NSCLC, while miR-520a-3p expression is decreased. SBF2-AS1 promotes the proliferation, migration, and invasion of NSCLC cells by regulating miR-520a-3p. High expression of SBF2-AS1 is associated with poor overall survival in NSCLC patients.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Oncology
Zhiwei He, Jie Wang, Changhao Zhu, Jian Xu, Peng Chen, Xueyi Jiang, Yankun Chen, Jianxin Jiang, Chengyi Sun
Summary: In this study, it was found that PC cells generate exosomes rich in FGD5-AS1, which promote M2 macrophage polarization and malignant behaviors of PC cells. FGD5-AS1 activates the STAT3/ NF-Kappa B pathway and interacts with p300, leading to STAT3 acetylation and nuclear localization. These findings highlight the important role of exosomal FGD5-AS1 in PC.
Article
Oncology
Yu Zhao, Cuancuan Wang, Tiejun Cui, Qiaoyi Wang, Yingchun Xu, Chunbo Miao, Shaoyan Liu
Summary: This study revealed the significant role of FGD5-AS1 in acute myocardial infarction (AMI), showing that it reduces myocardial injury by modulating the miR-223-3p/Akt pathway.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Su-Jie Gao, Sheng-Nan Ren, Yi-Ting Liu, Hong-Wei Yan, Xue-Bo Chen
Summary: This study reveals the key roles of EGFR and lncRNA-FGD5-AS1 in 5-Fu resistance in CRC, promoting glycolysis through miR-330-3p-HK2 axis and leading to resistance to 5-Fu. Inhibiting EGFR effectively enhances the anti-tumor toxicity of 5-Fu.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Orthopedics
Ou Shuang, Jianmin Zhou, Zijun Cai, Longteng Liao, Yuehua Wang, Wenyu Wang, Meng Xu
Summary: In this study, we found that G3BP2 is highly expressed in osteosarcoma cells and exacerbates their malignant behavior. MiR-124-3p was shown to negatively regulate the expression of G3BP2 in osteosarcoma cells. FGD5-AS1 was identified as a sponge for miR-124-3p and positively modulated G3BP2 expression. FGA5-AS1 promotes osteosarcoma cell proliferation by upregulating G3BP2. EBF1 was identified as the transcription factor for FGA5-AS1 and serves as a tumor facilitator in osteosarcoma cells.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Allergy
Binbin Li, Xiaoping Yu, Fuzhen Pang
Summary: This study reveals that the FGD5-AS1/miR-223-3p/COX11 axis plays a crucial role in the pathogenesis of allergic rhinitis, suggesting that FGD5-AS1 could serve as a potential diagnostic biomarker and therapeutic target for AR.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Na He, Linbiao Xiang, Lei Chen, Haobin Tong, Keshen Wang, Jie Zhao, Feixue Song, Hanteng Yang, Xinyuan Wei, Zuoyi Jiao
Summary: This review highlights the clinical significance of FGD5-AS1 in human cancer and its role in tumorigenesis and tumor progression. It emphasizes the abnormal high expression of FGD5-AS1 in various cancers and its close correlation with tumor characteristics such as lymph node metastasis and tumor invasion. Additionally, the potential application of FGD5-AS1 as a diagnostic or prognostic biomarker is discussed.
Article
Cell Biology
Junqing Chen, Ling Cheng, Weibin Zou, Rong Wang, Xiaojia Wang, Zhanhong Chen
Summary: The study reveals that ADAMTS9-AS1 can inhibit the progression of breast cancer by sequestering miR-301b-3p, involving the TGFBR2/JAK STAT signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiufang Yang, Huilan Du, Wenhui Bian, Qingxue Li, Hairu Sun
Summary: This study demonstrated that FOXD3-AS1 is upregulated in cervical cancer tissues and cells, promoting cell proliferation, migration, and invasion. High FOXD3-AS1 expression is associated with poor tumor differentiation, increased tumor size, and lymph node metastasis. FOXD3-AS1 directly targets miR-128-3p, leading to upregulation of LIMK1 expression in cervical cancer cells, thus facilitating cervical cancer progression.