Article
Oncology
Hala T. Borno, Mi-Ok Kim, Julian C. Hong, Sasha Yousefi, Amy Lin, Irina Tolstykh, Sylvia Zhang, Rana R. McKay, Olivier Harismendy, Pelin Cinar, Hope Rugo, Vadim S. Koshkin, Maya Rabow, Christine Wang, Adina Bailey, Eric J. Small
Summary: This study observed that patients with active cancer or advanced age are at an increased risk of death from COVID-19. These study observations can inform risk counseling for patients with cancer regarding COVID-19.
Article
Oncology
Noha Sharafeldin, Benjamin Bates, Qianqian Song, Vithal Madhira, Yao Yan, Sharlene Dong, Eileen Lee, Nathaniel Kuhrt, Yu Raymond Shao, Feifan Liu, Timothy Bergquist, Justin Guinney, Jing Su, Umit Topaloglu
Summary: The largest multicenter cohort of cancer patients with COVID-19 to date was constructed by the U.S. N3C collaboration. It was found that COVID-19 positivity significantly increased the risk of all-cause mortality in cancer patients. Factors such as age, gender, region, comorbidities, and specific cancer types were associated with increased mortality risk in cancer patients with COVID-19.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Julie Fu, Sonya A. Reid, Benjamin French, Cassandra Hennessy, Clara Hwang, Na Tosha Gatson, Narjust Duma, Sanjay Mishra, Ryan Nguyen, Jessica E. Hawley, Sunny R. K. Singh, David D. Chism, Neeta K. Venepalli, Jeremy L. Warner, Toni K. Choueiri, Andrew L. Schmidt, Leslie A. Fecher, Jennifer E. Girard, Mehmet A. Bilen, Deepak Ravindranathan, Sharad Goyal, Trisha M. Wise-Draper, Cathleen Park, Corrie A. Painter, Sheila M. McGlown, Gilberto de Lima Lopes Jr, Oscar K. Serrano, Dimpy P. Shah
Summary: This study aimed to investigate racial disparities in severity, clinical complications, and outcomes of COVID-19 between Black patients and non-Hispanic White patients with cancer. The study found that Black patients with cancer had worse COVID-19 outcomes, indicating a greater burden of COVID-19 in this population.
Article
Oncology
Manju Sengar, Girish Chinnaswamy, Priya Ranganathan, Apurva Ashok, Shilpushp Bhosale, Sanjay Biswas, Pankaj Chaturvedi, Chetan Dhamne, Jigeeshu Divatia, Karishma D'Sa, Hasmukh Jain, Sarbani Laskar, Nirmalya Roy Moulik, Naveen Mummudi, Sindhu Nair, Lingaraj Nayak, Prakash Nayak, Shraddha Patkar, Preeti Pawaskar, Anant Ramaswamy, Omshree Shetty, Arjun Singh, Epari Sridhar, Jayashree Thorat, Rajendra Badwe, C. S. Pramesh
Summary: Pramesh and colleagues conducted a study on the risk factors and outcomes in cancer patients infected with SARS-CoV-2 in India. They found that cancer patients are at higher risk for severe COVID-19. Advancing age, smoking history, concurrent comorbidities, and palliative intent of treatment were independently associated with severe COVID-19 or death.
Article
Oncology
Isaac A. Klein, Shoshana M. Rosenberg, Kerry L. Reynolds, Leyre Zubiri, Rachel Rosovsky, Andrew J. Piper-Vallillo, Xin Gao, Genevieve Boland, Aditya Bardia, Rachel Gaither, Hannah Freeman, Gregory J. Kirkner, Chanu Rhee, Michael Klompas, Meghan A. Baker, Martha Wadleigh, Eric P. Winer, Camille N. Kotton, Ann H. Partridge
Summary: The study found that patients with a history of cancer hospitalized for COVID-19 had similar mortality rates to matched hospitalized patients with COVID-19 without cancer, and a lower risk of complications. Active cancer, systemic cancer therapy, and a cancer history are not independent risk factors for death from COVID-19 among hospitalized patients, and hospitalized patients without cancer are more likely to have severe COVID-19.
Article
Virology
Toshiki Kuno, Matsuo So, Yoshihisa Miyamoto, Masao Iwagami, Mai Takahashi, Natalia N. Egorova
Summary: The study aimed to explore the association between hospitalizations of patients who tested positive for COVID-19 antibodies and reduced in-hospital mortality. Patients with positive COVID-19 antibody tests showed lower in-hospital mortality compared to those with negative test results after adjustments for patient characteristics and treatments. In conclusion, positive COVID-19 antibody test results were linked to a decreased risk of in-hospital mortality for COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Gretchen E. Glaser, Olivia D. Lara, Bhavana Pothuri, Carolina Gomez Grimaldi, Lauren S. Prescott, Spyridon A. Mastroyannis, Sarah Kim, Adam C. ElNaggar, Diogo Torres, Lesley B. Conrad, Michaela McGree, Amy Weaver, Warner K. Huh, David E. Cohn, S. Diane Yamada, Amanda N. Fader
Summary: This study aimed to describe the clinical courses, treatment changes, and short-term clinical outcomes for gynecologic oncology patients with concurrent COVID-19 in the United States. The results showed that gynecologic oncology patients diagnosed with COVID-19 are at risk for hospitalization, delay of anti-cancer treatments, and death. Approximately 5% of patients died within 30 days after COVID-19 diagnosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jessica E. Hawley, Tianyi Sun, David D. Chism, Narjust Duma, Julie C. Fu, Na Tosha N. Gatson, Sanjay Mishra, Ryan H. Nguyen, Sonya A. Reid, Oscar K. Serrano, Sunny R. K. Singh, Neeta K. Venepalli, Ziad Bakouny, Babar Bashir, Mehmet A. Bilen, Paolo F. Caimi, Toni K. Choueiri, Scott J. Dawsey, Leslie A. Fecher, Daniel B. Flora, Christopher R. Friese, Michael J. Glover, Cyndi J. Gonzalez, Sharad Goyal, Thorvardur R. Halfdanarson, Dawn L. Hershman, Hina Khan, Chris Labaki, Mark A. Lewis, Rana R. McKay, Ian Messing, Nathan A. Pennell, Matthew Puc, Deepak Ravindranathan, Terence D. Rhodes, Andrea Rivera, John Roller, Gary K. Schwartz, Sumit A. Shah, Justin A. Shaya, Mitrianna Streckfuss, Michael A. Thompson, Elizabeth M. Wulff-Burchfield, Zhuoer Xie, Peter Paul Yu, Jeremy L. Warner, Dimpy P. Shah, Benjamin French, Clara Hwang
Summary: The study aimed to quantify spatiotemporal variation in COVID-19 outcomes among cancer patients in the US. Results showed no significant differences in outcomes across US census divisions, but substantial heterogeneity was found across cancer care delivery centers.
Article
Oncology
Hitomi Suzuki, Tomohiro Akiyama, Nobuko Ueda, Satoko Matsumura, Miki Mori, Masatoshi Namiki, Norikazu Yamada, Chika Tsutsumi, Satoshi Tozaki, Hisayuki Iwamoto, Shun Torii, Yuichiro Okubo, Kiyosuke Ishiguro
Summary: Cancer patients are concerned about the effects of the COVID-19 vaccination. Consulting with a physician can alleviate their concerns and encourage vaccination.
Article
Biochemistry & Molecular Biology
Ittai Dayan, Holger R. Roth, Aoxiao Zhong, Ahmed Harouni, Amilcare Gentili, Anas Z. Abidin, Andrew Liu, Anthony Beardsworth Costa, Bradford J. Wood, Chien-Sung Tsai, Chih-Hung Wang, Chun-Nan Hsu, C. K. Lee, Peiying Ruan, Daguang Xu, Dufan Wu, Eddie Huang, Felipe Campos Kitamura, Griffin Lacey, Gustavo Cesar de Antonio Corradi, Gustavo Nino, Hao-Hsin Shin, Hirofumi Obinata, Hui Ren, Jason C. Crane, Jesse Tetreault, Jiahui Guan, John W. Garrett, Joshua D. Kaggie, Jung Gil Park, Keith Dreyer, Krishna Juluru, Kristopher Kersten, Marcio Aloisio Bezerra Cavalcanti Rockenbach, Marius George Linguraru, Masoom A. Haider, Meena AbdelMaseeh, Nicola Rieke, Pablo F. Damasceno, Pedro Mario Cruz E. Silva, Pochuan Wang, Sheng Xu, Shuichi Kawano, Sira Sriswasdi, Soo Young Park, Thomas M. Grist, Varun Buch, Watsamon Jantarabenjakul, Weichung Wang, Won Young Tak, Xiang Li, Xihong Lin, Young Joon Kwon, Abood Quraini, Andrew Feng, Andrew N. Priest, Baris Turkbey, Benjamin Glicksberg, Bernardo Bizzo, Byung Seok Kim, Carlos Tor-Diez, Chia-Cheng Lee, Chia-Jung Hsu, Chin Lin, Chiu-Ling Lai, Christopher P. Hess, Colin Compas, Deepeksha Bhatia, Eric K. Oermann, Evan Leibovitz, Hisashi Sasaki, Hitoshi Mori, Isaac Yang, Jae Ho Sohn, Krishna Nand Keshava Murthy, Li-Chen Fu, Matheus Ribeiro Furtado de Mendonca, Mike Fralick, Min Kyu Kang, Mohammad Adil, Natalie Gangai, Peerapon Vateekul, Pierre Elnajjar, Sarah Hickman, Sharmila Majumdar, Shelley L. McLeod, Sheridan Reed, Stefan Graf, Stephanie Harmon, Tatsuya Kodama, Thanyawee Puthanakit, Tony Mazzulli, Vitor Lima de Lavor, Yothin Rakvongthai, Yu Rim Lee, Yuhong Wen, Fiona J. Gilbert, Mona G. Flores, Quanzheng Li
Summary: Federated learning, a method for training artificial intelligence algorithms while protecting data privacy, was used to predict future oxygen requirements of symptomatic patients with COVID-19 using data from 20 different institutes globally. The study showed improved predictive accuracy and generalizability, setting the stage for wider applications in healthcare.
Article
Oncology
Haris Hatic, Kristine R. R. Hearld, Devika Das, Jessy Deshane
Summary: Patients with cancer who contract COVID-19 while receiving chemotherapy or immune checkpoint inhibitors (ICIs) are at higher risk of complications and mortality. This retrospective study found that COVID-19-related ICI mortality was higher compared to patients receiving chemotherapy. However, patients with better functional status and COVID-19 vaccination had reduced mortality.
Article
Oncology
Lisa Bondeson, Anna Thulin, Lars Ny, Max Levin, Johanna Svensson, Magnus Lindh, Zhiyuan Zhao
Summary: This study examined the incidence of COVID-19 among cancer patients at a large oncology department in Sweden and identified factors associated with poor outcomes and death. Among the findings, older age, palliative treatment intent, and transition to end-of-life care were associated with increased odds of death within 30 days. Male sex was found to be associated with needing hospital care for COVID-19. The case fatality rate among cancer patients with COVID-19 in this study was within the lower range of reported rates.
Article
Oncology
Shuchi Gulati, Chih-Yuan Hsu, Surbhi Shah, Pankil K. Shah, Rebecca Zon, Susan Alsamarai, Joy Awosika, Ziad El-Bakouny, Babar Bashir, Alicia Beeghly, Stephanie Berg, Daniel de-la-Rosa-Martinez, Deborah B. Doroshow, Pamela C. Egan, Joshua Fein, Daniel B. Flora, Christopher R. Friese, Ariel Fromowitz, Elizabeth A. Griffiths, Clara Hwang, Chinmay Jani, Monika Joshi, Hina Khan, Elizabeth J. Klein, Natalie Knox Heater, Vadim S. Koshkin, Daniel H. Kwon, Chris Labaki, Tahir Latif, Rana R. McKay, Gayathri Nagaraj, Elizabeth S. Nakasone, Taylor Nonato, Hyma V. Polimera, Matthew Puc, Pedram Razavi, Erika Ruiz-Garcia, Renee Maria Saliby, Aditi Shastri, Sunny R. K. Singh, Vicky Tagalakis, Diana Vilar-Compte, Lisa B. Weissmann, Cy R. Wilkins, Trisha M. Wise-Draper, Michael T. Wotman, James J. Yoon, Sanjay Mishra, Petros Grivas, Yu Shyr, Jeremy L. Warner, Jean M. Connors, Dimpy P. Shah, Rachel P. Rosovsky
Summary: This cohort study found that patients receiving anticancer therapy had a high risk of developing thromboembolic events in the context of COVID-19, and the risk varied by type of therapy, underlying risk factors, and demographics such as race and ethnicity. These findings highlight the importance of close monitoring and personalized thromboprophylaxis for patients with cancer to prevent COVID-19-related thromboembolism and associated morbidity and mortality.
Article
Oncology
Rebecca S. Parker, Justin Le, Andrew Doan, Paibel Aguayo-Hiraldo, Pia S. Pannaraj, Teresa Rushing, Jemily Malvar, Maurice R. O'Gorman, Jennifer Dien Bard, Chintan Parekh
Summary: Pediatric oncology patients are at higher risk for hospitalization with COVID-19, but the majority can undergo chemotherapy without delays in treatment. Viral load may be a potential predictor for the outcome of COVID-19 in pediatric cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Akin Osibogun, Mobolanle Balogun, Akin Abayomi, Jide Idris, Yetunde Kuyinu, Oluwakemi Odukoya, Ololade Wright, Remi Adeseun, Bamidele Mutiu, Babatunde Saka, Nike Osa, Dayo Lajide, Ismael Abdus-Salam, Bodunrin Osikomaiya, Oluwatosin Onasanya, Bisola Adebayo, Yewande Oshodi, Sunday Adesola, Olu Adejumo, Olufemi Erinoso, Hussein Abdur-Razzaq, Abimbola Bowale, Kingsley Akinroye
Summary: Data on comorbidities and their impact on COVID-19 outcomes among African populations are scarce. This study from Nigeria identified hypertension, diabetes, renal disease, cancer, and HIV as comorbidities that predict death in COVID-19 patients. The study suggests the importance of public awareness, early detection, and tailored care for COVID-19 patients with comorbidities.
