Article
Neurosciences
Chen-Long Yang, Jun-Jie Jing, Si-Yin Fu, Yu-Ling Zhong, Xiu-Zhu Su, Zhong-Mou Shi, Xiao-Zhi Wu, Fei Yang, Guo-Zhong Chen
Summary: This study assessed the impact of ropivacaine-induced seizures on pain hypersensitivity and found that seizures caused pain hypersensitivity for up to 5 days, with enhanced pronociceptive effects on postsurgical pain and acute inflammatory pain. The involvement of spinal 5-HT/5-HT3R signaling was identified as a crucial factor in the pain sensitization caused by seizures, suggesting it as a potential target for precise treatment of local anesthetic toxicity.
Article
Neurosciences
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Summary: This study demonstrates that mice harboring an Scn8a allele with a patient-derived mutation are susceptible to audiogenic seizures and seizure-induced death, providing a new model for studying seizure-induced death. Activation of adrenergic receptors is necessary and sufficient for recovery of breathing and prevention of seizure-induced death in this novel audiogenic seizure-induced death model.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Isra Tamim, David Y. Chung, Andreia Lopes de Morais, Inge C. M. Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J. Schiff, Cenk Ayata
Summary: The study demonstrates a reciprocal relationship between spreading depression and seizures in an animal model, showing that seizures trigger spreading depression, which then terminates the seizure and prevents its generalization.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Juan-Manuel Bonet-Fernandez, Pedro Tranque, Jose Daniel Aroca-Aguilar, Luis J. Munoz, Dolores E. Lopez, Julio Escribano, Carlos de Cabo
Summary: This study investigated the expression of NKCC1 protein in the GASH/Sal epilepsy model and found that seizure induction caused changes in NKCC1 expression, which were associated with alterations in GABA release. These findings suggest a critical role of NKCC1 in neuronal excitability during seizures and support NKCC1 contribution to the development of secondary foci of epileptogenic activity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Aoife Campbell, Gareth Morris, Albert Sanfeliu, Joana Augusto, Elena Langa, Jaideep C. Kesavan, Ngoc T. Nguyen, Ronan M. Conroy, Jesper Worm, Lukasz Kielpinski, Mads Aaboe Jensen, Meghan T. Miller, Thomas Kremer, Cristina R. Reschke, David C. Henshall
Summary: Angelman syndrome (AS) is a severe neurodevelopmental disorder. Inhibiting miR-134 and possibly other microRNAs may be beneficial in treating clinically relevant phenotypes with a later developmental window in AS.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Pharmacology & Pharmacy
Caterina De Sarro, Martina Tallarico, Maria Pisano, Luca Gallelli, Rita Citraro, Giovambattista De Sarro, Antonio Leo
Summary: The hormone GLP-1 has been identified as a potential target for the treatment of neurological diseases such as epilepsy. In this study, the effects of acute and chronic treatment with LIRA on epilepsy-prone rats were investigated. It was found that chronic treatment with LIRA had a modest antiseizure effect, while acute treatment did not show significant results. Additionally, chronic use of diazepam led to the development of tolerance, but when combined with LIRA, a reduced development of tolerance and an enhanced antiseizure effect were observed. Overall, LIRA as an add-on therapy showed superior benefits compared to single antiseizure medications in treating epilepsy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Sahika Guner, Tamila Akhayeva, Charles D. Nichols, Hakan Gurdal
Summary: The interaction between serotonin receptors and epidermal growth factor receptors (EGFR) was investigated in this study, with a focus on their role in vascular constriction. It was found that EGFR, Src, and PI3K play a role in serotonin-induced vasoconstriction, especially in the mesenteric artery. The upstream mediators of EGFR transactivation by serotonin were identified as Ca2+/CaM, Src, and PI3K, with Erk1/2 and Akt activation playing a partial role. Furthermore, different subtypes of serotonin receptors (5-HT2A and 5-HT1B) have varying effects on EGFR transactivation through Src and/or PI3K, with 5-HT2A having a greater impact than 5-HT1B receptors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Qiyi You, Qijun Li, Liyuan Lv, Zhihua Lin, Yinghui Dong, Hanhan Yao
Summary: Serotonin is a crucial substance in the gastrointestinal and central nervous systems, and its functions are regulated by binding to 5-HT receptors. This study identified and analyzed seven 5-HTR genes in Sinonovacula constricta, providing insights into their expression patterns and potential influences.
Article
Pharmacology & Pharmacy
Yu-Xin Zhang, Chen Li, Xiu-Rui Liang, Jia-Qi Jin, Yi Zhang, Fan Xu, Jing Guan, Ying-Ying Ma, Xiao-Nan Ma, Run-Kun Liu, Ji-Hua Fu
Summary: 5-hydroxytryptamine (5-HT) is involved in the pathological processes of several liver diseases, particularly acute liver injury induced by carbon tetrachloride (CCl4). The study showed that the expression of 5-HT2A receptor, 5-HT synthetase, and MAO-A in hepatocytes is upregulated by CCl4, leading to increased degradation of mitochondrial 5-HT and overproduction of reactive oxygen species (ROS). This may contribute to the development of acute liver injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychiatry
Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-Koenig, Deborah Janowitz, Hans J. Grabe
Summary: Previous studies have suggested a connection between childhood trauma, serotonergic neurotransmission, and alexithymia. The study found that childhood trauma and the rs6295 polymorphism have a significant interaction effect on alexithymia in male subjects.
PSYCHIATRY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Carlo N. G. Giachello, Yuen Ngan Fan, Matthias Landgraf, Richard A. Baines
Summary: The study shows that manipulation of neuronal activity during critical periods can permanently alter network function, and identifies nitric oxide as a key mediator of this activity, affecting synaptic transmission and susceptibility to seizures.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Minjie Wan, Zhanchuan Ma, Jiawen Han, Min Rao, Feng Hu, Pujun Gao, Xiaocong Wang
Summary: The 5-HT/5-HT7R signaling pathway helps to constrain inflammation through functional Bregs in ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Firas Fahoum, Sara Eyal
Summary: Intracerebroventricular (ICV) administration is explored as a means to deliver antiseizure and antiepileptic therapies to epileptic brain tissue. This route bypasses the blood-brain barrier, allowing restricted therapeutics to reach the brain while reducing systemic adverse reactions. However, efficacy may be limited when epileptogenic tissue is far from the ventricles. This article provides an overview of ICV delivery and its challenges, and compares it with other administration routes.
Article
Clinical Neurology
Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F. Cotten, Hua-Jun Feng
Article
Behavioral Sciences
Honghai Zhang, Haiting Zhao, Hua-Jun Feng
EPILEPSY & BEHAVIOR
(2017)
Article
Behavioral Sciences
Hua-Jun Feng, Carl L. Faingold
EPILEPSY & BEHAVIOR
(2017)
Article
Clinical Neurology
Hafting Zhao, Joseph F. Cotten, Xiaoyan Long, Hua-Jun Feng
Article
Neurosciences
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L. Faingold, Norman E. Taylor, Ken Solt, Hua-Jun Feng
NEUROBIOLOGY OF DISEASE
(2018)
Review
Pharmacology & Pharmacy
Hua-Jun Feng, Stuart A. Forman
PHARMACOLOGICAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Yiwei Liao, Xiang Liu, Youssef Jounaidi, Stuart A. Forman, Hua-Jun Feng
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Behavioral Sciences
Haiting Zhao, Honghai Zhang, Frederick J. Schoen, Steven C. Schachter, Hua-Jun Feng
EPILEPSY & BEHAVIOR
(2019)
Article
Chemistry, Medicinal
Abdelrahman R. Shalabi, Zhiyi Yu, Xiaojuan Zhou, Youssef Jounaidi, Hanwen Chen, Jiajia Dai, Daniel E. Kent, Hua-Jun Feng, Stuart A. Forman, Jonathan B. Cohen, Karol S. Bruzik, Keith W. Miller
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Anesthesiology
Yongyan Yang, Feng Liang, Jie Gao, Yuanlin Dong, Yiying Zhang, Guang Yang, Sulpicio G. Soriano, Hua-Jun Feng, Zhongcong Xie
Summary: The study showed that lower brain testosterone concentrations in neonatal male mice compared to adult male mice contributed to age-dependent tau phosphorylation and cognitive impairment after sevoflurane anesthesia. Testosterone treatment increased brain testosterone concentrations and alleviated anesthesia-induced tau phosphorylation and cognitive impairment.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medicine, Research & Experimental
Rui Zhang, Zheren Tan, Jianguo Niu, Hua-Jun Feng
Summary: The study demonstrates that noradrenergic neurotransmission modulates S-IRA predominantly via alpha 2 adrenoceptors in DBA/1 mice, indicating that selective activation of alpha 2 adrenoceptors can potentially prevent SUDEP.
Article
Clinical Neurology
Jialing Guo, Daniel Min, Hua-Jun Feng
Summary: The study demonstrates that genistein can significantly reduce the incidence of S-IRA in DBA/1 mice and specifically block S-IRA, effectively suppressing its occurrence. The inhibitory effect of genistein on S-IRA is dependent on activating alpha 2 adrenoceptors.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Carl L. Faingold, Hua-Jun Feng
Summary: Sudden unexpected death in epilepsy (SUDEP) is a common cause of death in epilepsy patients. Respiratory depression, caused by the release of adenosine during seizures, is the main factor leading to fatal cardiac arrest in witnessed SUDEP cases. However, the release of serotonin during seizures can counteract the respiratory depression caused by adenosine, potentially facilitating respiratory response mechanisms. Serotonergic drugs have shown promise in preventing post-seizure death and reducing postictal respiratory depression. The activation of brainstem sites, such as the periaqueductal gray (PAG), through serotonergic or direct approaches, may be beneficial for preventing SUDEP.
Editorial Material
Clinical Neurology
Carl L. L. Faingold, Hua-Jun Feng
Summary: We agree that more research is needed in response to the comments by Singh and colleagues. However, we believe that our hypothesis is timely and based on the progress in SUDEP-related research. We propose testing drugs and electrical stimulation for SUDEP prevention, and experiments using these methods are currently being carried out in animal studies. Temporizing treatments may help reduce the incidence of SUDEP sooner, which is urgently needed.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)