Article
Multidisciplinary Sciences
Yangming Hou, Yingjuan Xu, Dequan Wu
Summary: In this study, the infiltration of immune and stromal cells in gastric cancer patients was analyzed using bioinformatics algorithms, revealing that the expression of ADAMTS12 was significantly associated with poor prognosis and potentially served as a tumor promoter in the tumor microenvironment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Chenchen Mao, Liangliang Ma, Yingpeng Huang, Xinxin Yang, He Huang, Wentao Cai, Andriamifehimanjaka Sitrakiniaina, Ruihong Gu, Xiangyang Xue, Xian Shen
Summary: This study established an ASIRGPI prognostic index for Asian GC, showing high accuracy in predicting survival, with TGF beta 1 and EDNRB identified as potential therapeutic targets. The ASIRGPI model provides an effective approach for evaluating prognosis of Asian GC and selecting individualized therapy to potentially prolong OS.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Xiangyu Sui, Guohao Wu
Summary: By studying the molecular and immune aspects of gastric cancer, particularly focusing on cachexia, this research provides a deeper understanding of the mechanisms behind cachexia in gastric cancer, shedding light on potential advancements in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yin Jiang Zhang, Lin Yi Zhao, Xu He, Rong Fei Yao, Fan Lu, Bi Nan Lu, Zong Ran Pang
Summary: This study identified a prognostic CBXs model comprising five genes (CBX1, CBX2, CBX3, CBX7, and CBX8) for gastric cancer patients through bioinformatics analysis. CBXs were found to be associated with chromatin modifications and histone methylation, and significantly correlated with immune and molecular subtypes in gastric cancer. The risk score of the CBXs-related prognostic gene model was also found to be correlated with immune-cell infiltration and may predict the response to immune checkpoint inhibitors.
Article
Multidisciplinary Sciences
Lili Yi, Yongqiang Lei, Fengjiao Yuan, Conghui Tian, Jian Chai, Mingliang Gu
Summary: This study explores the relationship between NTN4 and prognosis as well as immune infiltration in breast cancer using public databases and immunohistochemistry. It found that NTN4 expression is significantly lower in invasive breast carcinoma and low expression is associated with poorer survival. Furthermore, NTN4 is closely related to infiltration levels of specific immune cells and varies among different subtypes of breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mengya Wang, Jingjing Jing, Hao Li, Jingwei Liu, Yuan Yuan, Liping Sun
Summary: The study identified specific characteristics of ATG gene expression in gastric cancer, with certain genes in the autophagy pathway playing key roles in tumor development and prognosis. Further research is needed to investigate specific ATG8/LC3 forms in order to provide insights for the discovery, diagnosis, or targeting of gastric cancer.
Article
Surgery
Zhaojun Xu, Xiaobin Chen, Jiaqi Yuan, Cheng Wang, Juan An, Xiaoming Ma
Summary: This study explores the correlations of a preoperative systemic immune-inflammation index and prognostic nutritional index with the prognosis of patients after radical gastric cancer surgery. The results demonstrate that both indices are independent risk factors for the prognosis of patients with gastric cancer, and their combination improves prediction efficiency.
Article
Mathematical & Computational Biology
Sizhe Hu, Peipei Li, Chenying Wang, Xiyong Liu
Summary: This study evaluated the prognostic significance of Biglycan (BGN) in gastric cancer. The results showed that high expression of BGN mRNA was significantly associated with poor prognosis, suggesting that BGN could be a potential prognostic biomarker and therapeutic target for gastric cancer.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kang Cao, Yanping Lyu, Jingwen Chen, Chenzhou He, Xuejie Lyu, Yuling Zhang, Liangping Chen, Yu Jiang, Jianjun Xiang, Baoying Liu, Chuancheng Wu
Summary: This study established a prognostic prediction model for gastric cancer patients based on a metabolism-associated signature and identified the unique role of metabolites in gastric cancer prognosis. The results indicated that purine metabolism and arachidonic acid metabolism play important roles in gastric cancer prognosis. The study highlights the important role of metabolites in the progression of gastric cancer and suggests that newly identified metabolites could be potential biomarkers or therapeutic targets for gastric cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Longxiang Xie, Qiang Wang, Zhongyi Yan, Yali Han, Xiaoyu Ma, Huimin Li, Lu Zhang, Xianzhe Li, Xiangqian Guo
Summary: In this study, a web-based portal called OSgc was developed to facilitate the evaluation of prognostic value of known and novel biomarker candidates in gastric cancer (GC). OSgc includes gene expression data and clinical follow-up information of 1,824 GC cases, and provides evaluation results for multiple survival endpoints.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Li Wei, Tian-Qi Luo, Jia-Ning Li, Zhi-Cheng Xue, Yun Wang, You Zhang, Ying-Bo Chen, Chuan Peng
Summary: A novel 19-gene risk predictive score model based on lipid metabolism-related genes was developed, which showed stability and reliability in gastric cancer patients. High-risk scores were associated with unfavorable overall survival, indicating it could be a potential prognostic indicator and therapeutic target for GC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Peipei Wang, Ying Zhu, Xinru Jia, Xiangchang Ying, Leitao Sun, Shanming Ruan
Summary: This study investigated the promoting effect of OSGIN2 on gastric cancer through databases and in vitro experiments. The relationship between OSGIN2 expression, prognosis, functional enrichment of differential genes, immune infiltration, and mutational information in gastric cancer was comprehensively analyzed. Knockdown of OSGIN2 inhibited tumor cell proliferation and affected the immune function. OSING2 is a potential biomarker and target for gastric cancer treatment.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Y. Li, X. He, L. Fan, X. Zhang, Y. Xu, X. Xu
Summary: This study developed an immune-related risk model for predicting prognosis and assessing the immune status of gastric cancer patients. The model, based on seven immune-related genes, showed potential in stratifying patients into different risk groups with different prognostic outcomes. Furthermore, the high-risk group exhibited higher levels of immunosuppressive cells and inhibitory immune checkpoints, suggesting a suppressive immune microenvironment in these patients.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Surgery
Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
Summary: This study retrospectively analyzed data from 5678 gastric cancer patients and found that fluorescent lymphography-guided lymphadenectomy (FL) can improve survival in stage III gastric cancer patients. Therefore, the use of FL is recommended in clinical practice.
INTERNATIONAL JOURNAL OF SURGERY
(2023)