Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
S. S. Prime, N. Cirillo, S. C. Cheong, M. S. Prime, E. K. Parkinson
Summary: This study reviews the molecular landscape of oral potentially malignant disorders, examining the impact of tumour heterogeneity and driver mutations on tumour progression. It proposes monitoring OPMD through liquid biopsies and highlights the identification of functional genes using CRISPR-Cas9 technology as translational implications for drug development.
Article
Oncology
Luigi Lorini, Michele Tomasoni, Cristina Gurizzan, Chiara Magri, Mattia Facchetti, Simonetta Battocchio, Chiara Romani, Marco Ravanelli, Arianna Oberti, Anna Bozzola, Elena Bardellini, Alberto Paderno, Davide Mattavelli, Davide Lombardi, Alberto Grammatica, Alberto Deganello, Fabio Facchetti, Stefano Calza, Alessandra Majorana, Cesare Piazza, Paolo Bossi
Summary: Oral potentially malignant disorders (OPMDs) are a group of tissue lesions that have the ability to transform into oral squamous cell carcinoma (OSCC). Despite optimal surgical treatment, approximately 20%-30% of OPMDs may progress into OSCC. No clear clinical/histological factors can identify OPMDs at higher risk of malignant transformation.
FRONTIERS IN ONCOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rishi S. Ramani, Ivy Tan, Lindsay Bussau, Christopher M. Angel, Michael McCullough, Tami Yap
Summary: Confocal microscopy has been explored for its utility in diagnosing oral squamous cell carcinoma and oral epithelial dysplasia. Quantitative software-based studies show potential in objectifying the diagnostic process for identifying abnormalities within the oral mucosa.
Review
Dentistry, Oral Surgery & Medicine
Alexander Ross Kerr, Giovanni Lodi
Summary: Managing patients with oral potentially malignant disorders is challenging due to the lack of understanding of natural history and validated predictive markers. Evidence-based health promotion is not widely embraced, and research on medical interventions often suffers from methodologic flaws and lack of focus on patient quality of life. Global networks with well-characterized patient populations are needed for better intervention trials.
Article
Dentistry, Oral Surgery & Medicine
Bassel Tarakji
Summary: This study assessed the knowledge, attitudes, and awareness of oral potentially malignant disorders (OPMDs) among general dentists and dental specialists in Saudi Arabia. The results showed that dental specialists had better knowledge and awareness of OPMDs compared to general dentists.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Health Care Sciences & Services
Olga Di Fede, Vera Panzarella, Fortunato Buttacavoli, Gaetano La Mantia, Giuseppina Campisi
Summary: Oral potentially malignant disorders are mucosal lesions and conditions with a higher risk of cancer development. Unfortunately, these disorders are often diagnosed late due to lack of attention in routine dental practice and a limited number of specialized oral medicine centers. This report discusses the DoctOral experience, which offers a smartphone-based decision support tool for healthcare professionals, allowing for immediate examination and diagnosis of oral lesions through interactive decision trees. The DoctOral mobile app has successfully revolutionized oral pathology by serving as an interactive platform for dental students and professionals to recognize and diagnose oral lesions.
Review
Medicine, General & Internal
Tanya Walsh, Saman Warnakulasuriya, Mark W. Lingen, Alexander R. Kerr, Graham R. Ogden, Anne-Marie Glenny, Richard Macey
Summary: This study aimed to evaluate the accuracy of different methods for early detection of oral cavity cancer, such as conventional oral examination, light-based detection, remote screening, and biomarker analysis. The results indicate that caution should be exercised in screening for oral cancer, as there is insufficient evidence to support the use of screening programs.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hans P. Sathasivam, John Casement, Timothy Bates, Philip Sloan, Peter Thomson, Max Robinson, Ralf Kist
Summary: This study identified 41 genes that were significantly differentially expressed between OPMD cases that underwent malignant transformation and those that did not. These candidate genes, including 23 downregulated and 11 upregulated protein-coding genes, may play a role in the malignant transformation of OPMD. Experiments are underway to validate these findings and contribute to a better understanding of the etiopathogenesis of OPMD.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Health Care Sciences & Services
Jewel Kai Lin See, Xinyao Liu, Federica Canfora, Caroline Moore, Michael Mccullough, Tami Yap, Rita Paolini, Antonio Celentano
Summary: This study systematically reviewed the evidence on the therapeutic effects of vitamin supplementation for oral potentially malignant disorders (OPMDs) and oral cancer (OC). The results showed that vitamin K, vitamin C, vitamin A, vitamin B, and vitamin D all had therapeutic benefits. The research on oral cancer was extensive, with a focus on oral lichen planus and oral leukoplakia among the OPMDs. However, standardizing the study design and outcomes is needed to enhance future research.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sivaraj Raman, Asrul Akmal Shafie, Mannil Thomas Abraham, Chen Kiong Shim, Thaddius Herman Maling, Senthilmani Rajendran, Sok Ching Cheong
Summary: Oral cancer poses a significant challenge to healthcare systems, particularly in Malaysia. This study aimed to determine the cost of treating oral potentially malignant disorders (OPMD) and oral cancer from a public healthcare provider's perspective. The research found that the cost of treating oral cancer is significantly higher than that of OPMD, with surgical care and personnel costs being the main contributors to the higher expenditure.
Article
Biochemistry & Molecular Biology
Maria Rosa Buenahora, Gloria Ines Lafaurie, Sandra J. Perdomo
Summary: The study found that DNA methylation regulation in oral potentially malignant disorders (OPMD) is associated with the involvement of HPV16-p16(INK4a), and hypermethylated genes in HPV infection are related to signaling pathways.
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Maria del Mar Roca-Rodriguez, Manuel Aguilar-Diosdado, Miguel Angel Gonzalez-Moles
Summary: The study revealed that patients with diabetes mellitus have a higher prevalence and greater chance of developing oral cancer and potentially malignant oral disorders compared to non-diabetic patients, with higher mortality rates for diabetic patients with oral cancer.
Article
Oncology
Kazuki Mori, Tomofumi Hamada, Mahiro Beppu, Hiroki Tsuchihashi, Yuichi Goto, Kenichi Kume, Hiroshi Hijioka, Keitaro Nishi, Yumiko Mishima, Tsuyoshi Sugiura
Summary: Using gargle fluid as a noninvasive screening tool can accurately diagnose early-stage oral cancer and distinguish it from oral potentially malignant disorders (OPMDs). The methylation panel of genes in gargle fluid is a reliable and noninvasive method for early cancer detection.
Article
Medicine, General & Internal
Sheng-Fu Chiu, Chung-Han Ho, Yi-Chen Chen, Li-Wha Wu, Yuh-Ling Chen, Jer-Horng Wu, Wei-Sheng Wu, Hui-Kun Hung, Wei-Fan Chiang
Summary: The study aimed to analyze the malignant transformation rate of oral potentially malignant disorders (OPMDs) and found that oral verrucous hyperplasia (OVH) had the highest malignant transformation possibility, with female OPMD patients having a relatively high malignant transformation rate.
Article
Oncology
Elisabetta Schiavello, Veronica Biassoni, Giovanna Gattuso, Marta Podda, Stefano Chiaravalli, Francesco Barretta, Manila Antonelli, Loris De Cecco, Emilia Pecori, Lorenza Gandola, Maura Massimino
Summary: This is a small series of homogeneously-treated DMG patients with H3K27M mutation. The treatment approach is similar to DIPG and the results obtained are comparable with those of DIPG patients. Therefore, these DMG patients should be included in registries and protocols of DIPG.
Article
Oncology
Giancarla Bernardo, Valentino Le Noci, Emerenziana Ottaviano, Loris De Cecco, Chiara Camisaschi, Simone Guglielmetti, Martina Di Modica, Giorgio Gargari, Francesca Bianchi, Serena Indino, Patrizia Sartori, Elisa Borghi, Michele Sommariva, Elda Tagliabue, Tiziana Triulzi, Lucia Sfondrini
Summary: This study highlights the significant influence of mammary tumor microbiota on local immune status and the relevance of its treatment with antibiotics, in combination with breast cancer therapies.
Review
Geriatrics & Gerontology
Maria Cossu Rocca, Luigi Lorini, Petr Szturz, Paolo Bossi, Jan B. Vermorken
Summary: Head and neck cancer, mainly squamous cell carcinoma, is a group of diseases that affect the mucosa lining the upper aerodigestive tract. Despite multimodality treatment, they often recur or progress, leading to poor prognosis. The treatment of older patients with head and neck squamous cell carcinoma is challenging due to their underrepresentation in clinical trials and lack of evidence-based guidelines. This article aims to address the specific needs of older patients, including differences in epidemiology and biology, measurement and use of frailty in treatment personalization, desired outcomes, and considerations for new treatments.
Article
Otorhinolaryngology
Anna Kaleva, Amit Raithatha, Michele Tomasoni, Daniele Borsetto, Ananth Vijendren
Summary: This study aims to compare the success rates and tolerability of local anaesthetic myringoplasty with those undertaken under general anaesthetic myringoplasty. The results showed no significant difference in the success rate of myringoplasty surgery between local and general anaesthesia. Factors such as minimizing anaesthetic risks, reducing costs, and reducing environmental impact can drive the choice of local anaesthetic surgery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Letter
Otorhinolaryngology
Davide Mattavelli, Michele Tomasoni, Marco Ferrari, Alberto Schreiber, Vittorio Rampinelli, Paolo Bossi, Cesare Piazza, Piero Nicolai
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Biology
Amelia Barcellini, Alexandra Charalampopoulou, Loris De Cecco, Andrei Fodor, Emanuela Rabaiotti, Giorgio Candotti, Simona Secondino, Angelica Facoetti, Laura Deborah Locati, Sandro Pignata, Ester Orlandi, Giorgia Mangili
Summary: Radiotherapy is increasingly being used in combination with surgery, chemotherapy, and novel drugs to treat ovarian cancer. This review aims to summarize the current understanding of the radiosensitivity and radioresistance of ovarian cancer, which is the deadliest gynecological cancer worldwide. Understanding the mechanisms of radiosensitivity and identifying potential biomarkers of radioresistance could be crucial in guiding clinical decision-making, considering the high rate of recurrence in and out of the radiotherapy fields, especially in the era of personalized oncology.
Review
Otorhinolaryngology
Michele Tomasoni, Elisa Marazzi, Vittorio Rampinelli, Davide Mattavelli, Alberto Schreiber, Alberto Deganello, Cesare Piazza
Summary: The aim of this study was to investigate the prevalence of cervical nodal metastasis in primary, treatment-naive olfactory neuroblastoma (ONB) at presentation and as disease relapse, as well as to review treatment modalities and risk factors for regional failure and survival outcomes based on nodal status. A systematic review and meta-analysis were conducted based on PubMed, Web of Science, and Scopus. The results showed that cervical nodal involvement is common in both the presentation and during follow-up of cN0 ONB. The highest risk of developing late nodal metastasis is seen in cN0 patients with Kadish stage C tumors not receiving elective neck treatment. Based on these findings, selective neck treatment should be encouraged in selected patients to improve regional control.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosue Scognamiglio, Michele Del Sesto, Germana Tognon, Daniela Califano, Clorinda Schettino, Paolo Chiodini, Francesco Perrone, Delia Mezzanzanica, Sandro Pignata, Antonella Tomassetti
Summary: The membrane expression of EGFR can serve as a prognostic biomarker in ovarian cancer patients and is associated with the efficacy of anti-angiogenic therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ivana Fiz, Marta Filauro, Claudio Sampieri, Alessandro Ioppi, Alberto Vallin, Francesco Fiz, Jan Costantin Koelmel, Davide Lancini, Cesare Piazza, Christian Sittel, Giorgio Peretti
Summary: This study investigated the impact of different stenosis and patient-related factors on complications in patients undergoing partial crico-tracheal or tracheal resection and anastomosis for advanced laryngotracheal stenosis. The presence of systemic comorbidities was found to be the only independent predictor of postoperative complications. Patients with complications required additional surgeries more frequently and had a longer duration of hospitalization.
Review
Otorhinolaryngology
Shravan V. Gowrishankar, Alex Fleet, Michele Tomasoni, Rory Durham, Rishi Umeria, Serena A. Merchant, Syed F. H. Shah, Jameel Muzaffar, Hassan Mohammed, Isla Kuhn, James Tysome, Matthew E. Smith, Neil Donnelly, Patrick Axon, Manohar Bance, Daniele Borsetto
Summary: This study aimed to estimate the rate of postoperative meningitis in patients following cochlear implants through a systematic review and meta-analysis. The overall rate of postoperative meningitis was estimated to be 0.07%, which is lower than prior estimates but still higher than the general population.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Gabriele Molteni, Riccardo Nocini, Francesco Mattioli, Meijin Nakayama, Rogerio A. Dedivitis, Giuditta Mannelli, Erika Crosetti, Carlos Miguel Chiesa-Estomba, Jon A. Sistiaga-Suarez, Leone Giordano, Andrea Galli, Marco Lionello, Giuseppe Mercante, Massimo Ralli, Matteo Fermi, Alejandro Klein-Rodriguez, Miguel Mayo-Yanez, Edoardo Serafini, Francesca Pirola, Alberto Paderno, Francesca Cambria, Nobuhiko Oridate, Daisuke Sano, Paolo Boscolo-Rizzo, Alberto Vito Marcuzzo, Giampiero Parrinello, Filippo Marchi, Alberto Maria Saibene, Manuel Tucciarone, Guillem Viscasillas, Karol Zelenik, Daniel Marin Ramos, Jose Palacios-Garcia, Giancarlo Tirelli, Raul Pellini, Gaetano Paludetti, Jacopo Galli, Giorgia Rossi, Marco De Vincentiis, Claudio Roberto Cernea, Giuseppe Spriano, Mario Bussi, Giorgio Peretti, Giovanni Succo, Cesare Piazza, Andy Bertolin, Luiz Paulo Kowalski, Livio Presutti, Andrea Sacchetto
Summary: This study aims to evaluate the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. The results showed significant differences in disease-specific survival (DSS) and disease-free survival (DFS) among patient groups stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN outperformed pN staging in stratifying patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Multidisciplinary Sciences
Chiara Romani, Luigi Lorini, Anna Bozzola, Eliana Bignotti, Michele Tomasoni, Laura Ardighieri, Mattia Bugatti, Simonetta Battocchio, Antonella Ravaggi, Davide Tomasini, Marco Ravanelli, Cristina Gurizzan, Davide Lombardi, Davide Mattavelli, Stefano Calza, Cesare Piazza, Paolo Bossi
Summary: Adenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor with a tendency to recur and decreased survival rates. Through gene expression analysis, specific pathway alterations associated with aggressive ACC were identified, providing new avenues for therapeutic intervention.
SCIENTIFIC REPORTS
(2023)
Letter
Surgery
Armando G. Licata, Chiara M. Ciniselli, Luca Sorrentino, Arianna Micali, Maria Grazia Daidone, Marcello Guaglio, Manuela Gariboldi, Paolo Verderio, Loris De Cecco, Maurizio Cosimelli
BRITISH JOURNAL OF SURGERY
(2023)
