Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion

EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review

(2020) François Fagotto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cathepsin L secretion by host and neoplastic cells potentiates invasion

(2019) Samantha S. Dykes et al.   Oncotarget

EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome

(2018) Sagar J. Pathak et al.   HUMAN MUTATION

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer

(2017) N V Sankpal et al.   ONCOGENE

Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells

(2016) Mei-ling Han et al.   ACTA PHARMACOLOGICA SINICA

Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer

(2016) Hongying Sui et al.   Oncotarget

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro

(2015) Andreas Seeber et al.   BMC CANCER

Cathepsin L targeting in cancer treatment

(2015) Dhivya R. Sudhan et al.   PHARMACOLOGY & THERAPEUTICS

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab

(2015) Andreas Seeber et al.   Oncotarget

Crystal structure and its bearing towards an understanding of key biological functions of EpCAM

(2014) Miha Pavšič et al.   Nature Communications

EpCAM proteolysis: new fragments with distinct functions?

(2013) Ulrike Schnell et al.   BIOSCIENCE REPORTS

EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2+, basal-like and HER2 intrinsic subtypes of breast cancer

(2013) S D Soysal et al.   BRITISH JOURNAL OF CANCER

Absence of cell-surface EpCAM in congenital tufting enteropathy

(2013) Ulrike Schnell et al.   HUMAN MOLECULAR GENETICS

EpCAM Modulates NF-κB Signaling and Interleukin-8 Expression in Breast Cancer

(2013) Narendra V. Sankpal et al.   MOLECULAR CANCER RESEARCH

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Expression, crystallization and preliminary X-ray characterization of the human epithelial cell-adhesion molecule ectodomain

(2011) Miha Pavšič et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Effects of EpCAM overexpression on human breast cancer cell lines

(2011) Johanna M Gostner et al.   BMC CANCER

Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancer

(2011) B T F van der Gun et al.   BRITISH JOURNAL OF CANCER

Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients

(2011) QINGYONG CHEN et al.   Oncology Letters

EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

(2010) Ranju Ralhan et al.   BMC CANCER

Catumaxomab

(2010) Rolf Linke et al.   mAbs

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

Nuclear signalling by tumour-associated antigen EpCAM

(2009) Dorothea Maetzel et al.   NATURE CELL BIOLOGY

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES