Synthesis, in-vitro evaluation, molecular docking, and kinetic studies of pyridazine-triazole hybrid system as novel α-glucosidase inhibitors

An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity

(2020) Fariba Peytam et al.   Scientific Reports

A decade of advances in the reaction of nitrogen sources and alkynes for the synthesis of triazoles

(2020) Jose S.S. Neto et al.   COORDINATION CHEMISTRY REVIEWS

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

(2020) Maria Villiou et al.   ACS Applied Materials & Interfaces

Glycosides and Glycoconjugates of the Diterpenoid Isosteviol with a 1,2,3-Triazolyl Moiety: Synthesis and Cytotoxicity Evaluation

(2020) Olga V. Andreeva et al.   JOURNAL OF NATURAL PRODUCTS

Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies

(2020) Setareh Moghimi et al.   BIOORGANIC CHEMISTRY

Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses

(2020) Nadjet Rezki et al.   BIOORGANIC CHEMISTRY

Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

(2019) Jacob Krall et al.   JOURNAL OF MEDICINAL CHEMISTRY

Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

(2019) Girdhar Singh Deora et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminoalkyl-substituted flavonoids: synthesis, cholinesterase inhibition, β-amyloid aggregation, and neuroprotective study

(2019) Laleh Faraji et al.   MEDICINAL CHEMISTRY RESEARCH

Design, click synthesis, anticancer screening and docking studies of novel benzothiazole-1,2,3-triazoles appended with some bioactive benzofused heterocycles

(2019) Mohamed Reda Aouad et al.   JOURNAL OF MOLECULAR STRUCTURE

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

(2019) Khurshed Bozorov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1,2,3/1,2,4-Triazole containing liquid crystalline materials: An up-to-date review of their synthetic design and mesomorphic behavior

(2019) Leon David Rodrigues et al.   JOURNAL OF MOLECULAR LIQUIDS

New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation

(2019) Eman M. Ahmed et al.   BIOORGANIC CHEMISTRY

6-Cinnamoyl-4-arylaminothienopyrimidines as highly potent cytotoxic agents: Design, synthesis and structure-activity relationship studies

(2019) Mahsa Toolabi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structures and biological evaluation of new pyridazine derivatives

(2019) Bholey Singh et al.   JOURNAL OF MOLECULAR STRUCTURE

Recent advances in the chemistry of pyridazine — an important representative of six-membered nitrogen heterocycles

(2019) P G Sergeev et al.   RUSSIAN CHEMICAL REVIEWS

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids

(2018) Mohamed Aouad et al.   MOLECULES

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study

(2018) Mina Saeedi et al.   BIOORGANIC CHEMISTRY

Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors

(2017) Guangcheng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α -Glucosidase inhibition by prenylated and lavandulyl compounds from Sophora flavescens roots and in silico analysis

(2017) Jang Hoon Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A mini review of the synthesis of poly-1,2,3-triazole-based functional materials

(2017) Jingpei Huo et al.   RSC Advances

Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors

(2016) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-substituted-4-aryl-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents with cardioprotective and ulcerogenic sparing effects

(2016) Deepika Sharma et al.   MEDICINAL CHEMISTRY RESEARCH

Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies

(2015) Fazal Rahim et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

(2013) Yakaiah Chinthala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents

(2012) Yasser M. S. A. Al-kahraman et al.   ARCHIVES OF PHARMACAL RESEARCH

Pyridazin-3(2H)-ones: the versatile pharmacophore of medicinal significance

(2012) Ranju Bansal et al.   MEDICINAL CHEMISTRY RESEARCH

Studies on α-Glucosidase Inhibitors Development: Magic Molecules for the Treatment of Carbohydrate Mediated Diseases

(2012) N. S.H.N. Moorthy et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations

(2012) Christoph Rosak et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

An evaluation of the potential side-effects of α-glucosidase inhibitors used for the management of diabetes mellitus

(2010) A. J. J. REUSER et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update

(2010) R. Tundis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY