Article
Chemistry, Medicinal
Celine Moriou, Damien Lacroix, Sylvain Petek, Amr El-Demerdash, Rozenn Trepos, Tinihauarii Mareva Leu, Cristina Florean, Marc Diederich, Claire Hellio, Cecile Debitus, Ali Al-Mourabit
Summary: Chemical investigation of the South-Pacific marine sponge led to the isolation of new bromotyrosine metabolites along with known congeners. Detailed configuration determination and absolute configurations of the compounds were achieved using various techniques. Additionally, evaluation of biological activities such as acetylcholinesterase inhibition and antifouling activities were conducted.
Article
Microbiology
Ipsita Mohanty, Subhasish Tapadar, Samuel G. Moore, Jason S. Biggs, Christopher J. Freeman, David A. Gaul, Neha Garg, Vinayak Agarwal
Summary: The study investigates the presence of bromotyrosine alkaloids in marine sponges from different geographical locations, revealing significant correlations between microbiomes and metabolomes. It also demonstrates a conservation of biosynthetic logic between different classes of sponge-derived natural products. Overall, the study highlights the interconnectedness between microbiomes and metabolomes in marine sponges.
Article
Chemistry, Organic
Shin-ichiro Kurimoto, Ayano Okamoto, Satsuki Seino, Jane Fromont, Jun'ichi Kobayashi, Takaaki Kubota
Summary: Two new bromotyrosine alkaloids were isolated from an Okinawan marine sponge Suberea sp., showing moderate cytotoxicity against L1210 murine leukemia cells in vitro.
TETRAHEDRON LETTERS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Michael Gross
Summary: Despite being often viewed as the most 'primitive' of multicellular animals, sponges play a crucial role in the early evolution of complex life and are important for marine ecology and environmental health. Their unique abilities in biomineralisation could also inspire advancements in modern materials science.
Article
Chemistry, Medicinal
Tomas Duminis, Marcin Heljak, Wojciech Swieszkowski, Alexander Ereskovsky, Izabela Dziedzic, Marek Nowicki, Martyna Pajewska-Szmyt, Alona Voronkina, Stefan R. Bornstein, Hermann Ehrlich
Summary: Skeletal constructs of marine sponges, especially those isolated from cultivated demosponges, have the potential to be sustainable sources of biocompatible porous biopolymer-based 3D scaffolds for tissue engineering. These chitinous scaffolds have shown promising results in biomimetics and tissue engineering due to their renewability and broad diversity of cells. However, the mechanical features of these constructs have been poorly studied before.
Article
Chemistry, Medicinal
Charifat Said Hassane, Gaetan Herbette, Elnur Garayev, Fathi Mabrouki, Patricia Clerc, Nicole J. de Voogd, Stephane Greff, Ioannis P. Trougakos, Jamal Ouazzani, Mireille Fouillaud, Laurent Dufosse, Beatrice Baghdikian, Evelyne Ollivier, Anne Gauvin-Bialecki
Summary: This study focused on the biological screening of marine sponge extracts and selected Scopalina hapalia extract for chemical study. Four new compounds were discovered through detailed spectroscopic analysis, and molecular networking was employed to further understand the chemical composition of this species.
Article
Chemistry, Medicinal
Marta Carnovali, Maria Letizia Ciavatta, Ernesto Mollo, Vassilios Roussis, Giuseppe Banfi, Marianna Carbone, Massimo Mariotti
Summary: With longer life expectancy, there has been an increased focus on discovering new healing agents for age-related disorders, including bone diseases. Marine organisms, known for their diverse bioactive metabolites, are being recognized as potential sources for therapeutic options. Additionally, the zebrafish model has proven to be an efficient and cost-effective platform for screening molecules that regulate bone development. In this study, the effects of the crude acetonic extract from the marine sponge Aplysina aerophoba and its bromotyrosine components on bone development were evaluated using zebrafish larvae. The results led to the identification of aerophobin-1 as a promising candidate for regenerative medicine and a potential novel therapeutic option for osteoporosis treatment.
Article
Environmental Sciences
Sasha D. Giametti, Christopher M. Finelli
Summary: Plastic waste is a common form of marine pollution that poses threats to wildlife. A method to detect plastic-associated compounds in sponge tissue was developed and applied to samples from the Florida Keys.
MARINE POLLUTION BULLETIN
(2022)
Review
Biology
Osama Mostafa, Mohammed Al-Shehri, Mahmoud Moustafa
Summary: Research has shown that compounds extracted from marine sponges contain a variety of active ingredients that are effective against parasites, including alkaloids, peroxides, and terpenoids, which have the potential to become antiparasitic drugs.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Disha Varijakzhan, Jiun-Yan Loh, Wai-Sum Yap, Khatijah Yusoff, Rabiha Seboussi, Swee-Hua Erin Lim, Kok-Song Lai, Chou-Min Chong
Summary: Marine sponges are valuable sources of bioactive compounds with antimicrobial and antiviral properties. These compounds can be used as antibacterial, antiviral, anti-malarial, and antifungal agents against human pathogens and fish pathogens. Their application as antimicrobial agents in veterinary commodities is also discussed.
Review
Biology
Tyler J. Carrier, Manuel Maldonado, Lara Schmittmann, Lucia Pita, Thomas C. G. Bosch, Ute Hentschel
Summary: This article integrates embryology and microbiology to review the transmission of symbiotic microorganisms in marine sponges. The study finds that vertical transmission is common but not universal, and that transmission occurs during specific developmental stages. Additionally, the microbial abundance in sponges influences the properties of the developmental microbiome.
Review
Biochemistry & Molecular Biology
Ahmed M. Elissawy, Ebrahim Soleiman Dehkordi, Negin Mehdinezhad, Mohamed L. Ashour, Pardis Mohammadi Pour
Summary: Marine sponges are a rich source of unique bioactive secondary metabolites, with alkaloids standing out for their unprecedented structures and outstanding biological activities. A comprehensive survey of demospongian bioactive alkaloids from 1987 to 2020 revealed that sponges from different genera within the phylum porifera are prolific sources of alkaloidal molecules. The production of alkaloids from sponges is a promising approach that merits more attention in future studies to address constraints related to drug supply from marine organisms.
Article
Chemistry, Medicinal
Alexander J. Craig, Yuri Ermolovich, Alan Cameron, Agnes Rodler, Helen Wang, Jeffrey A. Hawkes, Madlen Hubert, Fredrik Bjoerkling, Natalia Molchanova, Margaret A. Brimble, Lindon W. K. Moodie, Johan Svenson
Summary: Small synthetic mimics of cationic antimicrobial peptides are promising compounds for treating persistent microbial infections. In this study, we investigated the activity of 19 linear cationic tripeptides against pathogenic bacteria and fungi, including clinical isolates. Modified hydrophobic amino acids inspired by bioactive marine secondary metabolites were used to create compounds with improved safety profiles. Several compounds showed high activity, particularly against fungal strains, with low off-target toxicity to erythrocytes and HeLa cells, indicating effective ways to tune the activity and selectivity of short antimicrobial peptides.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
James J. Bell, Robert O. Smith, Valerio Micaroni, Francesca Strano, Celia A. Balemi, Paul E. Caiger, Kelsey I. Miller, Arie J. P. Spyksma, Nick T. Shears
Summary: Marine heat waves pose a greater threat to marine ecosystems than gradual increases in sea surface temperature. Unprecedented heat waves in New Zealand have severely impacted millions of sponges, leading to tissue necrosis and bleaching, with potential ecosystem-level consequences.
Article
Biochemistry & Molecular Biology
Tam M. T. Tran, Russell S. Addison, Rohan A. Davis, Bernd H. A. Rehm
Summary: The sponge-derived natural products ianthelliformisamines A-C can work synergistically with ciprofloxacin to reduce the minimum inhibitory concentration (MIC) of Pseudomonas aeruginosa biofilms. Ianthelliformisamine C exhibits bactericidal effects on both free-living and biofilm populations of various strains, including the clinically relevant mucoid variant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Tapan Kumar Jena, Faiz Ahmed Khan
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Review
Genetics & Heredity
Roy Anindya
Article
Chemistry, Organic
Tapan Kumar Jena, Faiz Ahmed Khan
TETRAHEDRON LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Deepa Akula, Timothy R. O'Connor, Roy Anindya
Summary: ALKBH5, known as a RNA N6-methyladenine demethylase, is also found to have weak DNA repair activity and can demethylate DNA 3-methylcytosine. Overexpression of ALKBH5 reduces the level of 3-methylcytosine in genomic DNA and decreases the cytotoxic effects of the DNA damaging alkylating agent. This suggests that demethylation by ALKBH5 may play a supporting role in maintaining genome integrity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Tapan Kumar Jena, Faiz Ahmed Khan
TETRAHEDRON LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Richa Nigam, Kaki Raveendra Babu, Topi Ghosh, Bhavini Kumari, Prolay Das, Roy Anindya, Faiz Ahmed Khan
Summary: The synthesized 2-chloro-3-amino indenone derivative 3o was identified as an inhibitor of AlkB, which could sensitize cells to methyl methanesulfonate that mainly produce DNA alkylation damage. This study established the potential of indenone-derived compounds as inhibitors of Fe(II)/2-oxoglutarate-dependent dioxygenase AlkB.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Review
Chemistry, Multidisciplinary
Sarwat Asma Ziya Ahmad, Tapan Kumar Jena, Faiz Ahmed Khan
Summary: Alkyl enol ethers (AEE) are versatile synthetic intermediates with unique reactivity patterns, capable of forming various bonds in intermolecular reactions. Their synthetic applications include metal-catalyzed reactions, cycloaddition, heterocycle formation, and reactions in natural product synthesis, showcasing their impressive potential in organic synthesis. The review aims to highlight the extensive use of AEE in reactions with both electrophiles and nucleophiles, demonstrating its ambiphilic reactivity and attracting chemists to explore AEE chemistry further. The intermolecular reactions of AEE with other functionalized moieties remain an unexplored area for future research.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Monisha Mohan, Mulla Althafh Hussain, Faiz Ahmed Khan, Roy Anindya
Summary: In this study, sixteen novel analogues of curcumin were investigated for their inhibition of COX-1 and COX-2. Most analogues displayed selective inhibition of COX-2, while a few suppressed COX-1 activity. Molecular docking analysis showed that compounds with pronounced selectivity for COX-2 exhibited better binding to COX-2 compared to curcumin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Unnikrishnan Paruthiyezhath Shaji, Nikhil Tuti, Susmita Das, Roy Anindya, Monisha Mohan
Summary: ALKBH2 is a human DNA repair enzyme that repairs methyl adducts in genomic DNA. Overexpression of ALKBH2 has been associated with tumorigenesis and chemotherapy resistance in certain cancers. In this study, we identified Ritonavir as a potential inhibitor of ALKBH2 through in silico evaluation of HIV protease inhibitors. Molecular dynamics simulation provided insights into the interaction between Ritonavir and ALKBH2. This suggests that Ritonavir could be used to target ALKBH2-mediated DNA alkylation repair.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Organic
Shivaji Narayan Khadake, Mosim Amin Pathan, Faiz Ahmed Khan
Summary: A general and catalyst-free method for synthesizing pyrido-oxazepine-3-ols and benzo-oxazin-2-yl methanol is described, involving tandem epoxide opening and SNAr reactions. The reaction of oxiranes derived from tribromopyridine yields seven-membered pyrido-oxazepine-3-ols, predominantly in the 2-cyclized form. On the other hand, oxiranes derived from tribromonitrobenzene produce six-membered benzo-oxazin-2-yl methanol, with primary amines favoring 2-cyclization and secondary amines leading to regioselective 4-cyclization.
Article
Engineering, Electrical & Electronic
Nabanita Chakraborty, Swati Ghosh Acharyya, Roy Anindya
Summary: A nanocomposite of graphene oxide, zinc oxide, and curcumin (GO-ZnO-cur) with a large surface area and abundant hydroxyl and carboxyl groups was synthesized for efficient removal of toxic Cd (II) ions from water. By optimizing the concentration of curcumin, the nanocomposite exhibited improved hydrophilicity and stability, and showed excellent adsorption capacity for Cd (II) at neutral pH and room temperature.
IEEE TRANSACTIONS ON NANOTECHNOLOGY
(2023)
Article
Chemistry, Organic
Rollania Negi, Tapan Kumar Jena, Jyoti, Nikhil Kumar Tuti, Roy Anindya, Faiz Ahmed Khan
Summary: A novel metal-free oxygenation reaction was reported, leading to the synthesis of several bioactive epoxy indenones and alpha-hydroxy indanones. The reaction mechanism was proposed, and a one-pot cis-hydroxy indanone protocol was achieved directly from biaryl indenone. The synthesized compounds were evaluated for inhibitory activity against the DNA repair protein AlkB, and one epoxide derivative showed specific inhibitory effects.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
