Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton

A facile synthesis, drug-likeness, and in silico molecular docking of certain new azidosulfonamide–chalcones and their in vitro antimicrobial activity

(2020) Muhamad Mustafa et al.   MONATSHEFTE FUR CHEMIE

Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)

(2020) Yang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model

(2019) Yan Jia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study

(2019) Muhamad Mustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

(2018) Mehlika Dilek Altıntop et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues

(2017) Muhamad Mustafa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Collagen I promotes hepatocellular carcinoma cell proliferation by regulating integrin β1/FAK signaling pathway in nonalcoholic fatty liver

(2017) Xinglong Zheng et al.   Oncotarget

Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

(2016) Nishant P. Visavadiya et al.   Cell Communication and Signaling

Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin-332/α3 integrin axis recovery of focal adhesion kinase ubiquitination

(2016) Amalia Azzariti et al.   HEPATOLOGY

Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway

(2015) DEBO KONG et al.   Experimental and Therapeutic Medicine

Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer

(2012) Hui-fang Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents

(2012) Xian-Hui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

(2012) Li-Rong Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, molecular modeling, and biological evaluation of 1,2,4-triazole derivatives containing pyridine as potential anti-tumor agents

(2012) Yan-Bin Zhang et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents

(2011) Juan Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

(2011) Craig A. Zificsak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

(2008) Daniel Lietha et al.   PLoS One