Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines

Recent human genetic errors of innate immunity leading to increased susceptibility to infection

(2020) Leen Moens et al.   CURRENT OPINION IN IMMUNOLOGY

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Coronavirus infections and immune responses

(2020) Geng Li et al.   JOURNAL OF MEDICAL VIROLOGY

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Viral load of SARS-CoV-2 in clinical samples

(2020) Yang Pan et al.   LANCET INFECTIOUS DISEASES

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

(2020) Lan T. Phan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies

(2020) Syed Faraz Ahmed et al.   Viruses-Basel

Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure

(2020) Chenjun Tang et al.   Viruses-Basel

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic?

(2020) Mayda Gursel et al.   ALLERGY

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

(2020) Ahmet Kursat Azkur et al.   ALLERGY

Eleven faces of coronavirus disease 2019

(2020) Xiang Dong et al.   ALLERGY

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

(2020) Mihai G. Netea et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 infection: the perspectives on immune responses

(2020) Yufang Shi et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)

(2020) Li Guo et al.   CLINICAL INFECTIOUS DISEASES

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

(2020) Jerome R. Lechien et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

(2020) Rong-Hui Du et al.   EUROPEAN RESPIRATORY JOURNAL

Herd Immunity: Understanding COVID-19

(2020) Haley E. Randolph et al.   IMMUNITY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage

(2020) Jingyuan Liu et al.   Journal of Translational Medicine

Human leukocyte antigen susceptibility map for SARS-CoV-2

(2020) Austin Nguyen et al.   JOURNAL OF VIROLOGY

Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures

(2020) Rachael Pung et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Phylogenetic network analysis of SARS-CoV-2 genomes

(2020) Peter Forster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection

(2020) Sedat G Kandemirli et al.   RADIOLOGY

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

(2020) Maria Romano et al.   Cells

Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment

(2020) Takahiko Koyama et al.   Pathogens

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

(2020) Houcemeddine Othman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Variant analysis of SARS-CoV-2 genomes

(2020) Takahiko Koyama et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2

(2020) Hui Wang et al.   CELL

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

(2020) Erik Alm et al.   Eurosurveillance

Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu

(2020) Yongli Zheng et al.   JOURNAL OF CLINICAL VIROLOGY

Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound?

(2020) Dominique Batisse et al.   JOURNAL OF INFECTION

SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

(2020) Giovanni Salvatori et al.   Journal of Translational Medicine

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Feng-Cai Zhu et al.   LANCET

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

(2020) Pedro M Folegatti et al.   LANCET

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

(2020) Noe B. Mercado et al.   NATURE

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

(2020) Neeltje van Doremalen et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

(2020) F. Javier Ibarrondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

(2020) Luis E. Escobar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presentation of New Onset Anosmia During the COVID-19 Pandemic

(2020) C. Hopkins et al.   RHINOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

(2020) Wei Deng et al.   SCIENCE

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

(2020) Andrew Rambaut et al.   Nature Microbiology

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine Design

(2020) Dongliang Wang et al.   Vaccines

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Natural history of COVID-19 and current knowledge on treatment therapeutic options

(2020) Wagner Gouvea dos Santos   BIOMEDICINE & PHARMACOTHERAPY

Symptomatic SARS-CoV-2 reinfection by a phylogenetically distinct strain

(2020) Jan Van Elslande et al.   CLINICAL INFECTIOUS DISEASES

Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis

(2020) Andreas Kronbichler et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of accessory genes in coronavirus genomes

(2020) Christian Jean Michel et al.   Virology Journal

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

(2020) Anita S. Iyer et al.   Science Immunology

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

(2020) Katharina Röltgen et al.   Science Immunology

Antibody responses to viral infections: a structural perspective across three different enveloped viruses

(2019) Charles D. Murin et al.   Nature Microbiology

Non-specific effects of BCG vaccine on viral infections

(2019) S.J.C.F.M. Moorlag et al.   CLINICAL MICROBIOLOGY AND INFECTION

Membrane binding proteins of coronaviruses

(2019) Entedar A J Alsaadi et al.   Future Virology

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development

(2019) Ayman Mubarak et al.   Journal of Immunology Research

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

(2018) Christin Müller et al.   ANTIVIRAL RESEARCH

Nextstrain: real-time tracking of pathogen evolution

(2018) James Hadfield et al.   BIOINFORMATICS

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

Molecular characteristic and pathogenicity analysis of a virulent recombinant avain infectious bronchitis virus isolated in China

(2018) K Y Feng et al.   POULTRY SCIENCE

Induction of adaptive immune response by self-aggregating peptides

(2018) Jesus Zepeda-Cervantes et al.   Expert Review of Vaccines

Why are RNA virus mutation rates so damn high?

(2018) Siobain Duffy   PLOS BIOLOGY

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Two novel porcine epidemic diarrhea virus (PEDV) recombinants from a natural recombinant and distinct subtypes of PEDV variants

(2017) Nanhua Chen et al.   VIRUS RESEARCH

Assessing the transmission dynamics of measles in Japan, 2016

(2017) Hiroshi Nishiura et al.   Epidemics

Ten-year immune persistence and safety of the HPV-16/18 AS04-adjuvanted vaccine in females vaccinated at 15-55 years of age

(2017) Tino F. Schwarz et al.   Cancer Medicine

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

(2016) Andrew J. Broadbent et al.   VACCINE

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

(2015) G. D. Grass et al.   BIOSCIENCE REPORTS

Editorial (Thematic Issue: Recent Advances in the Structure-Based Drug Design and Discovery)

(2015) Imtaiyaz Hassan   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Live attenuated vaccines: Historical successes and current challenges

(2015) Philip D. Minor   VIROLOGY

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

(2014) Kam-Leung Siu et al.   Cellular & Molecular Immunology

Structural Disorder in Viral Proteins

(2014) Bin Xue et al.   CHEMICAL REVIEWS

Coronaviruses: Important Emerging Human Pathogens

(2014) C. M. Coleman et al.   JOURNAL OF VIROLOGY

History of vaccination

(2014) S. Plotkin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nomenclature for Immune Correlates of Protection After Vaccination

(2012) S. A. Plotkin et al.   CLINICAL INFECTIOUS DISEASES

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-like particles: The new frontier of vaccines for animal viral infections

(2012) Elisa Crisci et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Vaccine discovery and translation of new vaccine technology

(2011) Rino Rappuoli et al.   LANCET

The development of vaccines: how the past led to the future

(2011) Stanley A. Plotkin et al.   NATURE REVIEWS MICROBIOLOGY

Vaccines: the Fourth Century

(2009) S. A. Plotkin   Clinical and Vaccine Immunology

HLA and Infectious Diseases

(2009) J. M. Blackwell et al.   CLINICAL MICROBIOLOGY REVIEWS

Future of polio vaccines

(2009) Ellie Ehrenfeld et al.   Expert Review of Vaccines

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

(2008) Yumiko Imai et al.   EXPERIMENTAL PHYSIOLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Does Mutation Rate Depend on Itself

(2008) Charles F Baer   PLOS BIOLOGY

SARS coronavirus replicase proteins in pathogenesis

(2007) Rachel L. Graham et al.   VIRUS RESEARCH