Article
Physiology
D. Clark Files, Kevin W. Gibbs, Christopher L. Schaich, Sean P. Collins, TanYa M. Gwathmey, Jonathan D. Casey, Wesley H. Self, Mark C. Chappell
Summary: The renin-angiotensin system (RAS) plays a key role in the pathobiology of COVID-19, and precise measurement of circulating RAS components is critical. Challenges in measuring RAS in COVID-19 include improper patient controls and unvalidated laboratory assays, highlighting the importance of studies like the prospective pilot study mentioned in the translation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Joseph Adu-Amankwaah, Richard Mprah, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Hong Sun
Summary: COVID-19 pandemic caused by SARS-CoV-2 has major health implications globally, with the virus entering hosts through ACE2 and affecting the cardiovascular system. Understanding the cardiovascular aspects of COVID-19 is crucial for improving cardiac health during and after the pandemic.
ANNALS OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Somasundaram Raghavan, R. Gayathri, Sudhakar Kancharla, Prachetha Kolli, J. Ranjitha, Vijayalakshmi Shankar
Summary: The SARS-CoV-2 virus not only primarily infects the lungs and respiratory system, but also affects the cardiovascular system and coagulation mechanisms, leading to various cardiovascular diseases. The virus enters endothelial cells through ACE2 receptors, thereby impacting the cardiovascular system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Pharmacology & Pharmacy
Ao Cheng, Honghao Ren, Zeyao Ma, Naqash Alam, Linying Jia, Enqi Liu
Summary: The new coronavirus has caused a worldwide pandemic and its impact on the cardiovascular system is significant. This study analyzed the relationship between COVID-19 and cardiovascular diseases through bibliometrics and visualization techniques. The findings suggest that SARS-CoV-2 has a higher infectivity rate and a higher incidence of cardiovascular diseases compared to SARS-CoV-1. The research focus has shifted from ACE2 and inflammation to the treatment of myocarditis and complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Yifan Zhao, Xiaorong Han, Cheng Li, Yucheng Liu, Jiayu Cheng, Binay Kumar Adhikari, Yonggang Wang
Summary: COVID-19 infection can cause cardiovascular diseases, such as myocarditis, myocardial infarction, and arrhythmia, posing a serious threat to the cardiovascular health of infected populations worldwide. It is still important to study the mechanisms linking COVID-19 to cardiovascular disease, despite slight improvements in cases due to virus mutation and population vaccination.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Larissa E. van Eijk, Mathijs Binkhorst, Arno R. Bourgonje, Annette K. Offringa, Douwe J. Mulder, Eelke M. Bos, Nikola Kolundzic, Amaal E. Abdulle, Peter H. J. van der Voort, Marcel G. M. Olde Rikkert, Johannes G. van der Hoeven, Wilfred F. A. den Dunnen, Jan-Luuk Hillebrands, Harry van Goor
Summary: COVID-19, caused by SARS-CoV-2, is a complex viral disease with varying symptoms, understanding its immunopathology and developing effective treatment strategies are crucial. Pathological observations provide valuable insights, current management strategies include supportive care and drug therapy.
JOURNAL OF PATHOLOGY
(2021)
Review
Chemistry, Medicinal
Choongho Lee, Won Jun Choi
Summary: The novel coronavirus SARS-CoV-2, known as COVID-19, has had a devastating impact on the global economy and healthcare systems, changing the definition of normal life. Developing effective therapeutics and preventive measures is crucial in fighting SARS-CoV-2 infection and restoring normalcy. Understanding COVID-19 pathogenesis is essential in guiding the development of anti-COVID-19 drugs and vaccines.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Barbara Malinowska, Marta Baranowska-Kuczko, Aleksandra Kicman, Eberhard Schlicker
Summary: CBD has shown promise as a potential treatment for COVID-19, with advantages such as reducing viral entry, inhibiting viral replication, and protecting multiple organs; however, further research is needed to explore its side effects, drug interactions, and optimal route of administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Rupinder Kaur, Shareen Singh, Thakur Gurjeet Singh, Pragati Sood, Jiki Robert
Summary: This article discusses the impact of COVID-19 on patients with comorbid conditions such as cardiovascular disease, diabetes, and Parkinson's disease, as well as explores the potential development of other symptoms and complications after infection. The article also mentions the mutation of the virus and the development of vaccines by various countries.
INFLAMMOPHARMACOLOGY
(2022)
Review
Cell Biology
Seyed Ali Ziai, Mitrasadat Rezaei, Sajad Fakhri, Ramin Pouriran
Summary: COVID-19, caused by the novel coronavirus, has posed a global challenge and highlights the urgent need for an effective vaccine. Understanding the virus's structure, entry mechanism, and pathogenesis is crucial in developing treatment strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Filippos Triposkiadis, Andrew Xanthopoulos, Grigorios Giamouzis, Konstantinos Dean Boudoulas, Randall C. Starling, John Skoularigis, Harisios Boudoulas, Efstathios Iliodromitis
Summary: ACE2 acts as the entry receptor for SARS-CoV-2 and can convert harmful substances to protective ones, suggesting that upregulation of ACE2 may be beneficial in mitigating COVID-19 risks. Limited involvement of ACE2 in the lung counter-regulatory RAS axis, increasing ACE2 expression may predispose to more severe disease, particularly in the presence of relevant risk factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Ellen A. Gorman, Jennifer Rynne, Hannah J. Gardiner, Anthony J. Rostron, Jonathan Bannard-Smith, Andrew M. Bentley, David Brealey, Christina Campbell, Gerard Curley, Mike Clarke, Ahilanadan Dushianthan, Phillip Hopkins, Colette Jackson, Kallirroi Kefela, Anna Krasnodembskaya, John G. Laffey, Cliona McDowell, Margaret McFarland, Jamie McFerran, Peter McGuigan, Gavin D. Perkins, Jonathan Silversides, Jon Smythe, Jacqui Thompson, William S. Tunnicliffe, Ingeborg D. M. Welters, Laura Amado-Rodriguez, Guillermo Albaiceta, Barry Williams, Manu Shankar-Hari, Daniel F. McAuley, Cecilia M. O'Kane
Summary: This study investigated the safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-19-related ARDS. The results showed that ORBCEL-C did not improve surrogate outcomes of pulmonary organ dysfunction. Evaluation: 7/10.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Luigi Camporota, Barnaby Sanderson, Davide Chiumello, Nicolas Terzi, Laurent Argaud, Thomas Rimmele, Romain Metuor, Aude Verstraete, Martin Cour, Julien Bohe, Vincent Piriou, Pascal Beuret, Claude Guerin
Summary: This study aimed to compare the response to prone position in patients with coronavirus disease 2019 acute respiratory distress syndrome and acute respiratory distress syndrome, and explore factors associated with survival. The results showed that prone position achieved similar oxygenation response in both patient groups and was associated with improved survival.
CRITICAL CARE MEDICINE
(2022)
Review
Obstetrics & Gynecology
Fei Chen, Shiheng Zhu, Zhiqing Dai, Lanting Hao, Chun Luan, Qi Guo, Chaofan Meng, Yankun Zhang
Summary: The COVID-19 pandemic has led to the rapid development and approval of multiple vaccines, including mRNA vaccines, which are considered ideal candidates. However, concerns about safety and efficacy have been raised, particularly regarding fertility. While current evidence is limited, studies suggest that COVID-19 mRNA vaccines do not have negative effects on fertility, even in pregnant women. Additional research, especially larger population-based studies, are needed to further assess the impact of vaccination on reproduction.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Maryam Besharati, Mahmoud Amouzadeh Tabrizi, Fatemeh Molaabasi, Reza Saber, Mojtaba Shamsipur, Javad Hamedi, Saman Hosseinkhani
Summary: Two biosensing methods utilizing NAD(P)H-dependent TetX2 enzyme activity and thionine were developed to detect tetracycline in milk. The methods showed great potential for being portable instruments for on-site TC measurements.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Biochemical Research Methods
Mohsen Isazadeh, Mojdeh Amandadi, Farnaz Haghdoust, Shima Lotfollazadeh, Mar Orzaez, Saman Hosseinkhani
Summary: This study used the split luciferase complementation assay to investigate the interactions of NLRP3 during inflammasome formation. By mutating the phosphomimetic residue at the interface of NLRP3 interactions, the designed biosensor was able to monitor the NLRP3PYD-NLRP3PYD interaction in vitro. This assay provides a specific method to study the PYD-PYD interaction and can be used to screen chemicals and drugs.
ANALYTICAL BIOCHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Sudabeh Iraninasab, Sana Sharifian, Ahmad Homaei, Mozafar Bagherzadeh Homaee, Tanvi Sharma, Ashok Kumar Nadda, John F. Kennedy, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: The biocatalytic conversion of greenhouse gases into commercial products using microbial enzymes, particularly carbonic anhydrase, is a promising approach to solving the issue of climate change. Carbonic anhydrases play a crucial role in converting CO2 into bicarbonate, thereby solidifying gaseous CO2 and reducing global warming effects.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2022)
Review
Biotechnology & Applied Microbiology
Mozhgan Razzaghi, Ahmad Homaei, Fabio Vianello, Taha Azad, Tanvi Sharma, Ashok Kumar Nadda, Roberto Stevanato, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: Immobilized enzyme-based catalytic constructs can improve industrial processes, while nano-enzymes are popular for their enhanced stability, reusability, and ease of separation. The properties of nanomaterials and protein surface composition play crucial roles in the preparation and catalytic properties of nano-enzymes.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Karim Hemati, Mohammad Hossein Pourhanifeh, Iman Fatemi, Azam Hosseinzadeh, Saeed Mehrzadi
Summary: Intervertebral disc degeneration (IVDD) is a leading cause of lower back pain. Excessive oxidative stress, inflammation, apoptosis, and disrupted autophagy contribute to IVDD pathogenesis. Melatonin, a powerful antioxidant, inhibits the destruction of the extracellular matrix in the disc and preserves ECM contents. These protective effects of melatonin are mediated through inhibition of oxidative stress, inflammation, apoptosis, and regulation of autophagy in IVD cells.
CURRENT DRUG TARGETS
(2022)
Article
Environmental Sciences
Mahmood Askari, Ahmad Homaei, Ehsan Kamrani, Farrokhzad Zeinali, Anna Andreetta
Summary: This study aimed to enhance understanding of biomass and soil carbon sequestration in an arid mangrove forest in Sirik, Hormozgan Province, Iran. The results showed significant differences in carbon storage in above and belowground biomass of mangrove areas, with forest soil storing the highest proportion of organic carbon in the ecosystem.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Marjan Abbasi Kheirabadi, Behnaz Saffar, Roohullah Hemmati, Mojtaba Mortazavi
Summary: In this study, heat- and pH-stable mutant phytases were generated using site-directed mutagenesis and their characteristics were analyzed. The mutants showed optimum activity at specific pH and temperature, and exhibited good thermal and pH stability. They also demonstrated high catalytic efficiency, making them suitable for application in the feed industry to increase mineral bioavailability and reduce soil and water pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Mohammad Ali Azadi, Roohullah Hemmati, Ahmad Homaei, Valiallah Khalaji-Pirbalouty
Summary: A novel aspartic protease was purified from Gammarus bakhteyaricus, showing high activity and stability. The enzyme exhibited high catalytic activity at low temperatures and in the presence of various salt concentrations, indicating its potential application in dairy processing.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Toxicology
Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi, Amir Mohammad Malvandi
Summary: This study analyzed the effects of aflatoxins on rat pancreatic islet cells, finding that these environmental toxins can impair the quality and function of the cells, potentially leading to endocrine disorders such as type-2 diabetes.
Article
Chemistry, Multidisciplinary
Y-S Borghei, S. Hosseinkhani, M. R. Ganjali
Summary: Magnetic nanoparticles (MNPs) have biomedical applications that can be classified based on their unique properties in the presence or removal of an external magnetic field. Magnetite nanoparticles, with their unique physicochemical and catalytic properties, have gained increasing attention in medical fields for diagnosis, imaging, therapy, and cellular/tissue engineering.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Agronomy
Mahdiye Kamali, Davood Samsampour, Abdoolnabi Bagheri, Ali Mehrafarin, Ahmad Homaei
Summary: This study aimed to investigate the genetic diversity and association mapping of germander populations in Iran. 18 ISSR markers and 17 morphophysiological traits were used, and significant differences among populations were observed. The study also identified markers associated with certain traits and provided a platform for future breeding and conservation programs.
GENETIC RESOURCES AND CROP EVOLUTION
(2023)
Article
Chemistry, Medicinal
Soudeh Bahramian Nasab, Ahmad Homaei, Roberto Fernandez-Lafuente, Jon Del Arco, Jesus Fernandez-Lucas
Summary: The use of marine enzymes as catalysts for biotechnological applications is a hot topic. In this study, a liver NADPH-dependent cytochrome P450 reductase (CPR) from the marine fish Liza klunzingeri (LkCPR) was isolated, purified and biochemically characterized. LkCPR showed remarkable catalytic features, such as a wide range of pH and temperature stability, high catalytic activity, and highest thermostability among reported CPRs. These findings suggest that LkCPR has great potential as a biocatalyst.
Article
Chemistry, Physical
Mohammad Reza Erfanimoghadam, Ahmad Homaei
Summary: The study aimed to isolate and identify symbiotic alpha-amylase enzyme-producing bacteria from the intestine of Silago Sihama and Rasterliger Canagorta fish living in Qeshm Island, Hormozgan. The bacteria were isolated using nutrient agar culture medium and screened for alpha-amylase production. The highest enzyme activity was found in four strains of Bacillus, which were identified and registered in the NCBI gene database. The alpha-amylase enzymes isolated from these bacteria have potential applications in various industries.
Article
Energy & Fuels
Robabeh Jafari, Ahmad Homaei, Ali-Reza Ahmadi, Ehsan Kamrani
Summary: This study compared the efficiency of astaxanthin extraction from Penaeus semisulcatus and Penaeus merguensis shrimp waste using two strains of Lactobacillus acidophilus and Lactobacillus plantarum bacteria. The results showed that P. semisulcatus waste had significantly higher extraction yield than P. merguiensis shrimp (p<0.05). L. plantarum bacteria had a higher ability to create better fermentation conditions and extract more astaxanthin from both shrimp species. The optimal conditions for this bacterium were a fermentation temperature of 35°C, a time of 72 hours, and a particle size of 80 mesh.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Ahmad Homaei, Khosro Khajeh, Reyhaneh Sariri, Ehsan Kamrani
Summary: Approximately 80% of luminous organisms live in the oceans, with a significant diversity of life depending on bioluminescence among marine organisms. Among vertebrates, luminous fish species are the only group capable of emitting bioluminescent light. The lantern fish family (Myctophidae) is considered the most prominent among the luminous fish of the deep oceans and seas. Benthosema pterotum, a lantern fish species, possesses bioluminescence due to scattered photophores in its ventral-lateral region. However, no research has been conducted on its bioluminescence system and light emission mechanism. This study aimed to determine the type of bioluminescence system in B. pterotum, specifically whether it involves pigments, photoproteins, or the luciferin-luciferase system. The findings revealed that B. pterotum belongs to the luciferin-luciferase type of light-emitting system. This research not only demonstrated innovation but also has the potential to pave the way for further studies in marine biochemistry and the production of recombinant active enzymes for various purposes.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
