Article
Obstetrics & Gynecology
Xiang Hua, Huahua Jiang, Na Guo, Yaoyao Du, Xiaoqiong Yuan, Taoran Deng, Xuemei Teng, Yangcheng Yao, Yufeng Li
Summary: Prepubertal exposure to Aroclor-1221 (A-1221) in rats resulted in reproductive impairment, including early puberty onset, extended estrous cycle, decreased hormone levels, and ovarian developmental abnormalities.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Patricia C. Henriques, Nayara S. S. Aquino, Ana C. Campideli-Santana, Juneo F. Silva, Roberta Araujo-Lopes, Celso R. Franci, Candido C. Coimbra, Raphael E. Szawka
Summary: The secretion of luteinizing hormone (LH) is regulated by fluctuations in circulating estradiol (E2), which oppositely regulate kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) of the hypothalamus. The different sensitivities of AVPV and ARC neurons to E2 play a key role in the control of periodic secretion of LH required for fertility in females.
Review
Endocrinology & Metabolism
Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara
Summary: Feedback from oestradiol is mediated by KP-neurons in the hypothalamus and RP3V regions, regulating the physiological menstrual cycle. Hypothalamic KP-neurons control GnRH pulsatility through negative feedback, while RP3V KP-neurons induce LH surge and ovulation through positive feedback.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Wenke Dong, Jingwei He, Junqi Wang, Wen Sun, Yanyan Sun, Jian Yu
Summary: This study found that BPA may cause precocious puberty by activating Kiss1 gene in the arcuate nucleus during the juvenile period, subsequently evoking AVPe neurons.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Hiroyuki Enomoto, Kinuyo Iwata, Keisuke Matsumoto, Mai Otsuka, Akio Morita, Hitoshi Ozawa
Summary: This study found that the progression of diabetes mellitus negatively affects Kisspeptin neurons in the arcuate nucleus (ARC) of female rats, but does not affect Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV). These findings suggest a potential role of ARC Kisspeptin neurons in menstrual disorders and infertility.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Tash-Lynn L. Colson, Shane R. de Solla, Valerie S. Langlois
Summary: Despite the ban on PCB production, PCBs are still found in the environment and wildlife tissues. Common snapping turtles have been used as indicators of PCB pollution, but the effects of PCBs on reptiles are largely unknown. This study suggests that juvenile snapping turtles may be able to metabolize low concentrations of PCBs, but further research is needed to assess the effects of PCB burdens on wild snapping turtles.
Article
Multidisciplinary Sciences
Anna Sobek, Sebastian Abel, Hamed Sanei, Stefano Bonaglia, Zhe Li, Gisela Horlitz, Arka Rudra, Kazumasa Oguri, Ronnie N. N. Glud
Summary: Persistent organic pollutants (POPs) are found in hadal trench sediment in the Atacama trench at depths down to 8085 m. High turnover of organic matter in the trench contributes to elevated contaminant concentrations in this extreme and remote place.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Moala K. Bannavti, Jacob C. Jahnke, Rachel F. Marek, Craig L. Just, Keri C. Hornbuckle
Summary: The study reveals that airborne PCB concentrations in schools are higher indoors than outdoors, originating from different sources. There are variations in concentration and congener profiles among different rooms, with higher levels found in older wing of the building. The congener distributions suggest both historical and modern sources of PCBs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Aylin Balci Ozyurt, Pinar Erkekoglu, Naciye Dilara Zeybek, Ali Asci, Unzile Yaman, Ofcan Oflaz, Murat Kizilgun, Evin Iscan, Tugce Batur, Mehmet Ozturk, Belma Kocer-Gumusel
Summary: Polychlorinated biphenyls (PCBs) were widely used in various industries but were later banned due to their high toxicity. Aroclor 1254 (A1254), a commercial PCB congener, accumulates in the environment, leading to high human exposure. A1254 has been found to cause hepatotoxicity, metabolic disorders, and endocrine disorders. Our study on male rats showed that A1254 resulted in histological changes, oxidative stress, and apoptosis in the liver. Selenium deficiency aggravated oxidative stress and apoptosis, while selenium supplementation provided partial protection. More mechanistic in vivo experiments are needed to further evaluate the hepatotoxicity of PCBs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Andrology
Sathish Kumar Thangavelu, Manju Mohan, Ilangovan Ramachandran, Arunakaran Jagadeesan
Summary: The study found that lactational exposure to PCBs may affect the Leydig cell function in progeny rats through epigenetic mechanisms, leading to hypermethylation of SF-1, Sp1/3, LHR and AR genes and potentially transcriptional repression of these genes.
Article
Reproductive Biology
Karen E. Weis, Lindsay M. Thompson, Madeline Streifer, Isabella Guardado, Jodi A. Flaws, Andrea C. Gore, Lori T. Raetzman
Summary: Polychlorinated-biphenyls (PCBs) are industrial compounds that were widely used but are now banned due to health concerns. A specific type of PCB mixture, Aroclor 1221 (A1221), has been found to affect reproductive function in rodents. In this study, the effects of A1221 exposure during different developmental periods on hormone and receptor expression in female rats were investigated. The results showed that prenatal exposure to A1221 increased pituitary luteinizing hormone beta (Lhb) mRNA and gonadotrope cell number in neonates, while decreasing LH hormone concentration. Additionally, exposure to A1221 during postnatal development increased pituitary follicle stimulating hormone beta (Fshb) mRNA levels and estrogen receptor alpha (ER alpha) levels in mature rats. These findings suggest that exposure to A1221 during critical developmental periods can alter pituitary hormone and receptor expression, potentially impacting reproductive function.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Zoology
Michael P. Reilly, M. Nicole Kunkel, Lindsay M. Thompson, Andrew Zentay, Connor D. Weeks, David Crews, Lawrence K. Cormack, Andrea C. Gore
Summary: Exposure to endocrine disrupting chemicals (EDCs) disrupts hormone systems, particularly affecting fetuses and infants. Prenatal exposure to polychlorinated biphenyls (PCBs) can impact hypothalamic development and neuropeptides in rats.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2022)
Article
Engineering, Environmental
Hui Wang, Andrea Adamcakova-Dodd, Hans-Joachim Lehmler, Keri C. Hornbuckle, Peter S. Thorne
Summary: Indoor air in schools contaminated with PCBs may pose health risks to children, teachers, and staff. Our study found that long-term inhalation exposure to PCBs impaired memory, induced anxiety-like behavior, reduced white blood cell counts, and influenced metabolism and gene transcription.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Environmental Sciences
Mathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen
Summary: Exposure to certain flame retardants, PCBs, phthalates, and pesticides may potentially increase the risk of thyroid cancer according to existing literature, but more research is urgently needed to evaluate the carcinogenic effects of different EDCs on the thyroid gland in humans.
Article
Environmental Sciences
Guilherme R. Lotufo, Philip T. Gidley, Andrew D. McQueen, David W. Moore, Deborah A. Edwards, Jeffery Hardenstine, Allen D. Uhler
Summary: This study investigated the bioavailability of PCBs associated with paint chips dispersed in sediment, finding that the bioavailability of PCBs from paint chips mixed in sediment was significantly lower than that of field-collected sediments. These results are important for risk assessment and remediation decision-making at sites where contamination from non-paint PCB sources is present.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)