Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects

Mechanism of Fully Reversible, pH-Sensitive Inhibition of Human Glutamine Synthetase by Tyrosine Nitration

(2020) Benedikt Frieg et al.   Journal of Chemical Theory and Computation

Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency

(2020) Maian Roifman et al.   CLINICAL GENETICS

Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver

(2019) Natalia Qvartskhava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1

(2019) Jing Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

(2018) Thomas Leibing et al.   HEPATOLOGY

Clarifying the Catalytic Mechanism of Human Glutamine Synthetase: A QM/MM Study

(2017) Cátia Moreira et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations

(2016) Federico M. Issoglio et al.   BIOCHEMISTRY

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34

(2016) Verónica Demicheli et al.   BIOCHEMISTRY

Reaction Mechanism ofMycobacterium TuberculosisGlutamine Synthetase Using Quantum Mechanics/Molecular Mechanics Calculations

(2016) Cátia Moreira et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxidative Inactivation of Human Glutamine Synthetase: Biochemical and Computational Studies

(2016) Silvina Bartesaghi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies

(2016) Benedikt Frieg et al.   PLoS Computational Biology

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase

(2015) Natalia Qvartskhava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells

(2015) Ahmad Merhi et al.   PLoS One

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

(2012) Rafael Radi   ACCOUNTS OF CHEMICAL RESEARCH

Glutamine supplementation in a child with inherited GS deficiency improves the clinical status and partially corrects the peripheral and central amino acid imbalance

(2012) Johannes Häberle et al.   Orphanet Journal of Rare Diseases

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

Natural course of glutamine synthetase deficiency in a 3year old patient

(2011) Johannes Häberle et al.   MOLECULAR GENETICS AND METABOLISM

Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration

(2010) Diego M. Moreno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy

(2010) Boris Görg et al.   HEPATOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity

(2009) Dieter Häussinger et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy

(2008) Hans-J. Bidmon et al.   EPILEPSIA

Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

(2007) Wojciech W. Krajewski et al.   JOURNAL OF MOLECULAR BIOLOGY