Detection of Parkinson's disease using automated tunable Q wavelet transform technique with EEG signals

Deep brain simulations play an important role to study physiological and neuronal behavior during Parkinson's disease (PD). Electroencephalogram (EEG) signals may faithfully represent the changes that occur during PD in the brain. But manual analysis of EEG signals is tedious, and time consuming as these signals are complex, non-linear, and non-stationary nature. Therefore EEG signals are required to decompose into multiple subbands (SBs) to get detailed and representative information from it. Experimental selection of basis function for the decomposition may cause system degradation due to information loss and an increased number of misclassification. To address this, an automated tunable Q wavelet transform (A-TQWT) is proposed for automatic decomposition. A-TQWT extracts representative SBs for analysis and provides better reconstruction for the synthesis of EEG signals by automatically selecting the tuning parameters. Five features are extracted from the SBs and classified different machine learning techniques. EEG dataset of 16 healthy controls (HC) and 15 PD (ON and OFF medication) subjects obtained from openneuro is used to develop the automated model. We have aimed to develop an automated model that effectively classify HC subjects from PD patients with and without medication. The proposed method yielded an accuracy of 96.13% and 97.65% while the area under the curve of 97% and 98.56% for the classification of HC vs PD OFF medication and HC vs PD ON medication using least square support vector machine, respectively. (C) 2021 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

Deep brain simulations are important for studying physiological and neuronal behavior in Parkinson's disease. EEG signals can accurately reflect changes in the brain during PD, but manual analysis of these signals is time-consuming due to their complex nature. An automated tunable Q wavelet transform (A-TQWT) was proposed for automatic decomposition of EEG signals, achieving high accuracy in classifying healthy controls and PD patients with and without medication.