Article
Pharmacology & Pharmacy
Eleonore Coppens, Didier Desmaele, Timothee Naret, Sebastien Garcia-Argote, Sophie Feuillastre, Gregory Pieters, Catherine Cailleau, Jean-Louis Paul, Bastien Prost, Audrey Solgadi, Jean-Philippe Michel, Magali Noiray, Patrick Couvreur, Simona Mura
Summary: The study showed that inducing drug insertion into lipoproteins through chemical modification is a simple approach to achieve lipoprotein-mediated drug delivery. While the lipid moiety plays a key role in the interaction between the drug and lipoproteins, the overall physicochemical features of the nanoparticles must also be carefully considered.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Zhuo Yao, Qida Hu, Piaopiao Jin, Bowen Li, Yong Huang, Fu Zhang, Meng Wang, Junming Huang, Jing Huang, Shiyi Shao, Xinyu Zhao, Yuan Ping, Tingbo Liang
Summary: A small molecular self-assembly nano-prodrug was developed for the co-delivery of GEM, Ferrocene, and nutlin-3a, which can induce GEM-induced apoptosis with ferroptosis. The nano-prodrug was encapsulated into plectin1 receptor-targeting phospholipid micelles (DSPE-PEG-PTP) to enhance tumor accumulation and maintain stability in systemic circulations.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Andreas Peil, Ling Xin, Steffen Both, Luyao Shen, Yonggang Ke, Thomas Weiss, Pengfei Zhan, Na Liu
Summary: Researchers have successfully demonstrated the DNA assembly of a rotary nanodevice that mimics the mechanism of bacterial flagellar motor. This study provides new insights for designing and building artificial nanomachinery.
Article
Chemistry, Physical
Yuting Liang, Di Xiang, Ying Hou, Guangshe Li, Shouhua Feng, Ming Yang
Summary: The research shows that size is a common structural driving force for controlling hierarchical assembly of inorganic nanoparticles into anisotropic superstructures. The increase in size creates an effective kinetic barrier at different attachment sites, switching the assembly pathway from thermodynamically preferred 3D to kinetically favored 1D. Furthermore, the size-encoded hierarchical assembly is accompanied by ligand-controlled Oswald ripening process, resulting in the variation of hierarchical patterns from chains to tubules.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yue Wu, Yanqiong Yang, Yan Zhang, Liwei Dai, Wenhao Dong, Huibin He, Hao Li, Zhihong Nie, Yutao Sang
Summary: This study demonstrates a photo-induced self-assembly process of binary nanoparticles with complementary copolymer ligands, leading to the formation of high-yield clusters or linear structures of colloidal molecules. By varying the irradiation duration and mixing order, precise control of different structures can be achieved, offering various applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Michele Dai, Evangelos Georgilis, Guillaume Goudounet, Bertrand Garbay, Jan Pille, Jan C. M. van Hest, Xavier Schultze, Elisabeth Garanger, Sebastien Lecommandoux
Summary: This study reports the design and study of an ELP diblock library based on ELP-[M1V3-i]-[I-j], which showed a thermal phase transition with three distinct regimes by selectively oxidizing methionines of ELP-[M1V3-i] within the different diblocks structures.
Review
Chemistry, Physical
Rituraj Borah, A. G. Karthick Raj, Antony Charles Minja, Sammy W. Verbruggen
Summary: The synthesis and self-assembly of functional nanoparticles have attracted significant attention in recent years. The self-organization of nanoparticles into ordered structures is important for creating functional interfaces and enhancing their properties. This review provides an overview of recent developments in nanoparticle self-assembly and discusses their applications. Different techniques for obtaining these nanostructures and their impact on performance are also discussed.
Article
Chemistry, Multidisciplinary
Arixin Bo, Yawei Liu, Bjoern Kuttich, Tobias Kraus, Asaph Widmer-Cooper, Niels de Jonge
Summary: Self-assembly of nanoscale structures at liquid-solid interfaces plays a crucial role in industrial processes and natural phenomena. The conventional theory is oversimplified, and in situ observations using liquid-phase scanning transmission electron microscopy are required. It has been found that modifying the molecular coating of the substrate can control the self-assembly structures of nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Darya Filimonova, Anastasia Nazarova, Luidmila Yakimova, Ivan Stoikov
Summary: Novel monosubstituted pillar[5]arenes with one or two terminal carboxyl groups were synthesized and their ability for self-assembly in different solvent systems was studied. The synthesized macrocycles can form various types of associates depending on the substituent nature. Under appropriate conditions, stable nanoparticles or nanorods can be formed, which show good stability.
Article
Chemistry, Multidisciplinary
Ji Liu, Tianli Luo, Yifei Xue, Lanqun Mao, Peter J. Stang, Ming Wang
Summary: The hierarchical self-assembly of metal-organic cages into supramolecular nanoparticles allows for efficient encapsulation of proteins for intracellular delivery and potential therapeutic applications, such as CRISPR/Cas9 genome editing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Tuomo Viitaja, Jukka Moilanen, Kirsi Johanna Svedstrom, Filip S. Ekholm, Riku O. Paananen
Summary: The study found that the interaction of different tear film lipid species can improve the evaporation resistance, potentially paving the way for improved dry eye treatments and other applications where water evaporation is a challenge.
Article
Nanoscience & Nanotechnology
Calle Preger, Martin Josefsson, Rasmus Westerstrom, Maria E. Messing
Summary: Directed self-assembly of charged magnetic aerosolized nanoparticles with tunable size and composition has been demonstrated using combined electric and magnetic fields, resulting in a variety of nanostructures. The magnetization of nanoparticles and the orientation of external magnetic fields play key roles in governing the self-assembly process. These results highlight the potential of aerosol deposition in a combined electric and magnetic field for tailored bottom-up fabrication of nanostructures.
Article
Chemistry, Multidisciplinary
Wang Li, Ke Sun, Lisong Yang, Xi Mao, Shuai Deng, Hui Jiang, Pan Gu, Bowen Cao, Wen Li, Mingdong Yi, Colin D. D. Bain, Renhua Deng, Jintao Zhu
Summary: This study provides a solution to the challenge of in situ fabrication of macroscale ordered nanoparticle monolayers on targeted substrates by developing a colloidal ink formulation and employing the direct-ink-writing (DIW) technique. The ordered monolayer, consisting of polystyrene-grafted gold nanoparticles (Au@PS NPs) embedded in a PS thin film, is deposited through on-demand ink delivery and directional evaporation. The approach allows for fine control of NP self-assembly and shows enhanced performance compared to a disordered NP film prepared by spin coating, making it promising for various applications including electronic and optical devices.
Article
Multidisciplinary Sciences
Johannes Menath, Jack Eatson, Robert Brilmayer, Annette Andrieu-Brunsen, D. Martin A. Buzza, Nicolas Vogel
Summary: Researchers have successfully designed two-dimensional assemblies with structural complexity by utilizing the distinct interfacial morphology of soft particles. They found that core-shell particles can form complex chain and cluster structures under interfacial compression. Through a combination of experimental, simulation, and theoretical analysis, the interaction parameter of the system was narrowed down to between 0.9 and 2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Josef Jampilek, Katarina Kralova
Summary: According to the WHO, cancer caused almost 10 million deaths worldwide in 2020, with breast, lung, colon and rectal, and prostate cancers being the most common types. TKIs have revolutionized oncology and hematology as a gentler form of targeted therapy, but they come with significant side effects and limited efficacy. The reformulation of TKIs into lipid-based nanosystems holds promise for improving drug delivery and resistance development.
Article
Pharmacology & Pharmacy
Eleonore Coppens, Didier Desmaele, Timothee Naret, Sebastien Garcia-Argote, Sophie Feuillastre, Gregory Pieters, Catherine Cailleau, Jean-Louis Paul, Bastien Prost, Audrey Solgadi, Jean-Philippe Michel, Magali Noiray, Patrick Couvreur, Simona Mura
Summary: The study showed that inducing drug insertion into lipoproteins through chemical modification is a simple approach to achieve lipoprotein-mediated drug delivery. While the lipid moiety plays a key role in the interaction between the drug and lipoproteins, the overall physicochemical features of the nanoparticles must also be carefully considered.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)