Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis

Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria

(2020) Artyom Y. Baev et al.   BIOCHEMICAL JOURNAL

Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?

(2020) Emily A. Borden et al.   PHARMACOLOGICAL RESEARCH

Role of Polyphosphate in Amyloidogenic Processes

(2019) Justine Lempart et al.   Cold Spring Harbor Perspectives in Biology

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

(2019) Elizabeth Haythorne et al.   Nature Communications

Inorganic polyphosphate is required for sustained free mitochondrial calcium elevation, following calcium uptake

(2019) Maria E. Solesio et al.   CELL CALCIUM

Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity

(2018) María E. Solesio et al.   AGING CELL

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

(2018) Maria Peiris-Pagès et al.   Oncotarget

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

(2018) Shafiul Alam et al.   Journal of the American Heart Association

Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation

(2018) Lea K. Seidlmayer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Rebalancing β-Amyloid-Induced Decrease of ATP Level by Amorphous Nano/Micro Polyphosphate: Suppression of the Neurotoxic Effect of Amyloid β-Protein Fragment 25-35

(2017) Werner Müller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular polyphosphate signals through Ras and Akt to primeDictyostelium discoideumcells for development

(2017) Patrick M. Suess et al.   JOURNAL OF CELL SCIENCE

Polyphosphate as a donor of high-energy phosphate for the synthesis of ADP and ATP

(2017) Werner E. G. Müller et al.   JOURNAL OF CELL SCIENCE

From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore

(2017) Giuseppe Federico Amodeo et al.   Cell Death & Disease

Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore

(2016) M. E. Solesio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium

(2016) M.E. Solesio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Polyphosphate: A Conserved Modifier of Amyloidogenic Processes

(2016) Claudia M. Cremers et al.   MOLECULAR CELL

Developmental accumulation of inorganic polyphosphate affects germination and energetic metabolism inDictyostelium discoideum

(2016) Thomas Miles Livermore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

Oxidative stress protection by polyphosphate—new roles for an old player

(2015) Michael J Gray et al.   CURRENT OPINION IN MICROBIOLOGY

Protein Quality Control under Oxidative Stress Conditions

(2015) Jan-Ulrik Dahl et al.   JOURNAL OF MOLECULAR BIOLOGY

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

(2015) Carmela Guido et al.   Oncotarget

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Methods for Assessing Mitochondrial Function in Diabetes

(2013) C. G. R. Perry et al.   DIABETES

Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System

(2013) Bongki Cho et al.   Experimental Neurobiology

The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease

(2012) María E. Solesio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activatiing the mitochondrial fission pathway

(2012) Maria E Solesio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inorganic polyphosphate–an unusual suspect of the mitochondrial permeability transition mystery

(2012) Lea K. Seidlmayer et al.   Channels

Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes

(2012) Lea K. Seidlmayer et al.   JOURNAL OF GENERAL PHYSIOLOGY

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

(2012) J Hagenbuchner et al.   ONCOGENE

Characterization of Mitophagy in the 6-Hydoxydopamine Parkinson’s Disease Model

(2012) Maria E. Solesio et al.   TOXICOLOGICAL SCIENCES

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase

(2011) S. Bang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Inositol Pyrophosphates on Cellular Energy Dynamics

(2011) Z. Szijgyarto et al.   SCIENCE

Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis

(2010) Olivier Henry et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Development of an in vitro model of neuronal activity induced excitotoxicity using photoconductive stimulation

(2010) Evgeny Pavlov et al.   CELL CALCIUM

Inorganic Polyphosphate and Energy Metabolism in Mammalian Cells

(2010) Evgeny Pavlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

High Sensitivity, Quantitative Measurements of Polyphosphate Using a New DAPI-Based Approach

(2008) Roozbeh Aschar-Sobbi et al.   JOURNAL OF FLUORESCENCE