AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest

(2018) Lucija Belužić et al.   Scientific Reports

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins

(2017) Katsuhiro Kawaai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

(2016) Andrey A. Parkhitko et al.   GENES & DEVELOPMENT

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

IRBIT: A regulator of ion channels and ion transporters

(2014) Hideaki Ando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes

(2014) A. Arnaoutov et al.   SCIENCE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes

(2010) Randall Grubbs et al.   JOURNAL OF INHERITED METABOLIC DISEASE

S-adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome

(2009) Oliver Vugrek et al.   HUMAN MUTATION

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

The IRBIT domain adds new functions to the AHCY family

(2008) Benoit Devogelaere et al.   BIOESSAYS

Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells

(2008) Tanvi S Jani et al.   CELL RESEARCH