Journal
ENZYME AND MICROBIAL TECHNOLOGY
Volume 95, Issue -, Pages 146-154Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.enzmictec.2016.09.008
Keywords
Biosynthesis; Silver nanoparticle; Escherichia coli; Anticancer activity
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Funding
- Ministry of Earth Sciences (MoES), ICMAMPD, Under Coastal Research Scheme entitled Seawater Quality Monitoring Programme [ICMAMPD/SWQM/CASMB/35/2012]
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In the present investigation, the bacterium Escherichia coli (VMI) was isolated from a marine sediments of Ennore coastal water along southeast coast of India was exploited for its capability of Ag NPs synthesis. The derived nanoparticles were characterized employing ultraviolet-visible (UV-vis) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction and High Resolution Transmission Electron Microscopy (HRTEM) studies. The Ag NPs were further subjected to MIT assay to evaluate their anticancer activity against human lung cancer cell line (A549), human cervical cancer cell line (HeLa) and normal (Vero) cell line. The marine E.coli (VMI) synthesized silver nanoparticles exhibited considerable cytotoxic influence against human cancer cell lines, thereby suggesting that they have tremendous potential as effective anticancer agents. (C) 2016 Elsevier Inc. All rights reserved.
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