Overview of structurally homologous flavoprotein oxidoreductases containing the low Mr thioredoxin reductase-like fold – A functionally diverse group

Redox and Thiols in Archaea

(2020) Mamta Rawat et al.   Antioxidants

Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities

(2020) Meilin Zhu et al.   JOURNAL OF NATURAL PRODUCTS

The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase

(2020) Marta Hammerstad et al.   BIOCHEMISTRY

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis

(2020) Yuta Tsunematsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus

(2019) Irina V. Mikheyeva et al.   MOLECULAR MICROBIOLOGY

Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight

(2019) Madhuparna Bose et al.   BIOCHIMIE

Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections

(2019) Nico Linzner et al.   Frontiers in Microbiology

Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

(2019) Raoul De Gasparo et al.   CHEMISTRY-A EUROPEAN JOURNAL

DALI and the persistence of protein shape

(2019) Liisa Holm   PROTEIN SCIENCE

Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase

(2018) Nataliya Archipowa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Role of Bacillithiol in Gram-Positive Firmicutes

(2018) Pete Chandrangsu et al.   ANTIOXIDANTS & REDOX SIGNALING

Review of NAD(P)H-dependent oxidoreductases: Properties, engineering and application

(2018) Lara Sellés Vidal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S -bacillithiolation in Staphylococcus aureus

(2018) Marcel Imber et al.   Redox Biology

The Characterization of Different Flavodoxin Reductase-Flavodoxin (FNR-Fld) Interactions Reveals an Efficient FNR-Fld Redox Pair and Identifies a Novel FNR Subclass

(2018) Ingvild Gudim et al.   BIOCHEMISTRY

Redox regulation by reversible protein S-thiolation in Gram-positive bacteria

(2018) Marcel Imber et al.   Redox Biology

CATH: expanding the horizons of structure-based functional annotations for genome sequences

(2018) Ian Sillitoe et al.   NUCLEIC ACIDS RESEARCH

Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases

(2018) Rubén M. Buey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Member of the Thioredoxin Reductase Family from Early Oxygenic Photosynthetic Organisms

(2017) Rubén M. Buey et al.   Molecular Plant

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

C-terminal residues of ferredoxin-NAD(P)+ reductase from Chlorobaculum tepidum are responsible for reaction dynamics in the hydride transfer and redox equilibria with NADP+/NADPH

(2017) Daisuke Seo et al.   PHOTOSYNTHESIS RESEARCH

Interaction and electron transfer between ferredoxin–NADP+ oxidoreductase and its partners: structural, functional, and physiological implications

(2017) Paula Mulo et al.   PHOTOSYNTHESIS RESEARCH

Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase

(2017) Rubén M. Buey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction

(2017) Tristan Wagner et al.   SCIENCE

Biochemical Function, Molecular Structure and Evolution of an Atypical Thioredoxin Reductase from Desulfovibrio vulgaris

(2017) Odile Valette et al.   Frontiers in Microbiology

Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus

(2016) Marie Lofstad et al.   BIOCHEMISTRY

Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism

(2016) David Leys et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders

(2016) Irina F. Sevrioukova   JOURNAL OF MOLECULAR BIOLOGY

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases

(2016) Maria Laura Mascotti et al.   JOURNAL OF MOLECULAR BIOLOGY

BRENDA in 2017: new perspectives and new tools in BRENDA

(2016) Sandra Placzek et al.   NUCLEIC ACIDS RESEARCH

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Involvement of reductases IruO and NtrA in iron acquisition byStaphylococcus aureus

(2015) Mélissa Hannauer et al.   MOLECULAR MICROBIOLOGY

A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction

(2015) Jun Chen et al.   mBio

Redox regulation by reversible protein S-thiolation in bacteria

(2015) Vu Van Loi et al.   Frontiers in Microbiology

Flavoenzyme-Catalyzed Formation of Disulfide Bonds in Natural Products

(2014) Daniel H. Scharf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Redox Partners and Development of a Novel Chimeric Bacterial Nitric Oxide Synthase for Structure Activity Analyses

(2014) Jeffrey K. Holden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13

(2014) Chantel N. Jensen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Role of the C-terminal extension stacked on the re-face of the isoalloxazine ring moiety of the flavin adenine dinucleotide prosthetic group in ferredoxin-NADP+ oxidoreductase from Bacillus subtilis

(2014) Daisuke Seo et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Protein glutathionylation in health and disease

(2013) Pietro Ghezzi   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

Sulfolobus tokodaii ST2133 is characterized as a thioredoxin reductase-like ferredoxin:NADP+ oxidoreductase

(2013) Zhen Yan et al.   EXTREMOPHILES

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

IruO Is a Reductase for Heme Degradation by IsdI and IsdG Proteins inStaphylococcus aureus

(2013) Slade A. Loutet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations of an NAD(P)H-dependent flavoprotein monooxygenase that influence cofactor promiscuity and enantioselectivity

(2013) Chantel N. Jensen et al.   FEBS Open Bio

Low-Molecular-Weight Thiols in Thiol–Disulfide Exchange

(2012) Koen Van Laer et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Bacillithiolation Protects Conserved and Essential Proteins Against Hypochlorite Stress in Firmicutes Bacteria

(2012) Bui Khanh Chi et al.   ANTIOXIDANTS & REDOX SIGNALING

Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

(2012) Bret D. Wallace et al.   BIOCHEMISTRY

Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

(2012) Marcel Deponte   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Flavoprotein Monooxygenase that Catalyses a Baeyer-Villiger Reaction and Thioether Oxidation Using NADH as the Nicotinamide Cofactor

(2012) Chantel N. Jensen et al.   CHEMBIOCHEM

Exploring the Structural Basis of Substrate Preferences in Baeyer-Villiger Monooxygenases

(2012) Stefano Franceschini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiprotein Heme Shuttle Pathway in Staphylococcus aureus: Iron-Regulated Surface Determinant Cog-Wheel Kinetics

(2012) Michael T. Tiedemann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Escherichia coliClass Ib Ribonucleotide Reductase Contains a Dimanganese(III)-Tyrosyl Radical Cofactor in Vivo

(2011) Joseph A. Cotruvo et al.   BIOCHEMISTRY

Streptomyces clavuligerusHlmI Is an Intramolecular Disulfide-Forming Dithiol Oxidase in Holomycin Biosynthesis

(2011) Bo Li et al.   BIOCHEMISTRY

Flavogenomics - a genomic and structural view of flavin-dependent proteins

(2011) Peter Macheroux et al.   FEBS Journal

Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

(2011) Federico C. Beasley et al.   INFECTION AND IMMUNITY

Two Structures of anN-Hydroxylating Flavoprotein Monooxygenase

(2011) Jose Olucha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snapshots of Enzymatic Baeyer-Villiger Catalysis

(2011) Roberto Orru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Electron Transfer in a Protein Network Lacking Specific Interactions

(2011) Francesca Meschi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

S-Bacillithiolation Protects Against Hypochlorite Stress inBacillus subtilisas Revealed by Transcriptomics and Redox Proteomics

(2011) Bui Khanh Chi et al.   MOLECULAR & CELLULAR PROTEOMICS

An Active Dimanganese(III)−Tyrosyl Radical Cofactor inEscherichia coliClass Ib Ribonucleotide Reductase

(2010) Joseph A. Cotruvo et al.   BIOCHEMISTRY

Guidelines for tunneling in enzymes

(2010) Christopher C. Moser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The use of thiols by ribonucleotide reductase

(2010) Arne Holmgren et al.   FREE RADICAL BIOLOGY AND MEDICINE

Asymmetric Dimeric Structure of Ferredoxin-NAD(P)+ Oxidoreductase from the Green Sulfur Bacterium Chlorobaculum tepidum: Implications for Binding Ferredoxin and NADP+

(2010) Norifumi Muraki et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Sulfide:Quinone Oxidoreductase from Acidithiobacillus ferrooxidans: Insights into Sulfidotrophic Respiration and Detoxification

(2010) Maia M. Cherney et al.   JOURNAL OF MOLECULAR BIOLOGY

Transannular Disulfide Formation in Gliotoxin Biosynthesis and Its Role in Self-Resistance of the Human PathogenAspergillus fumigatus

(2010) Daniel H. Scharf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Crystal structure analysis of Bacillus subtilis ferredoxin-NADP+ oxidoreductase and the structural basis for its substrate selectivity

(2010) Hirofumi Komori et al.   PROTEIN SCIENCE

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

(2010) A. K. Boal et al.   SCIENCE

A novel electron transport system for thermostable CYP175A1 fromThermus thermophilusHB27

(2009) Takao Mandai et al.   FEBS Journal

Subcellular Localization of the Staphylococcus aureus Heme Iron Transport Components IsdA and IsdB

(2009) G. Pishchany et al.   INFECTION AND IMMUNITY

Terpyridine–platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1

(2009) Yan-Chung Lo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Siderophore-mediated iron acquisition in the staphylococci

(2009) Federico C. Beasley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structural biology of heme binding in the Staphylococcus aureus Isd system

(2009) Jason C. Grigg et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

(2009) I. Ahmad Mirza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence for two conformational states of thioredoxin reductase from Escherichia coli: Use of intrinsic and extrinsic quenchers of flavin fluorescence as probes to observe domain rotation

(2009) Scott B. Mulrooney et al.   PROTEIN SCIENCE

Crystal structure of reduced thioredoxin reductase from Escherichia coli: Structural flexibility in the isoalloxazine ring of the flavin adenine dinucleotide cofactor

(2009) Brett W. Lennon et al.   PROTEIN SCIENCE

Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system

(2008) Rosmarie Friemann et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and functional diversity of ferredoxin-NADP+ reductases

(2008) Alessandro Aliverti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Studies of interaction of homo-dimeric ferredoxin-NAD(P)+ oxidoreductases of Bacillus subtilis and Rhodopseudomonas palustris, that are closely related to thioredoxin reductases in amino acid sequence, with ferredoxins and pyridine nucleotide coenzymes

(2008) Daisuke Seo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1

(2008) Qing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of the Iron-regulated Surface Determinant (Isd) Heme Transfer Pathway inStaphylococcus aureus

(2008) Naomi Muryoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY