Fur-like proteins: Beyond the ferric uptake regulator (Fur) paralog

Mechanistic insights into heme-mediated transcriptional regulation via a bacterial manganese-binding iron regulator, iron response regulator (Irr)

(2020) Dayeon Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli

(2020) Chelsey R Fontenot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification, Functional Characterization, and Regulon Prediction of the Zinc Uptake Regulator (zur) of Bacillus anthracis – An Insight Into the Zinc Homeostasis of the Pathogen

(2019) Divya Kandari et al.   Frontiers in Microbiology

Regulation by FurC in Anabaena links the oxidative stress response to photosynthetic metabolism

(2019) Emma Sevilla et al.   PLANT AND CELL PHYSIOLOGY

The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferi

(2019) Charlotte Mason et al.   Frontiers in Cellular and Infection Microbiology

New insights into the tetrameric family of the Fur metalloregulators

(2019) S. Nader et al.   BIOMETALS

Evaluation of the regulatory model for Ni2+ sensing by Nur from Streptomyces coelicolor

(2019) Olivia M. Manley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Identification of zinc and Zur-regulated genes in Corynebacterium diphtheriae

(2019) Eric D. Peng et al.   PLoS One

Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli

(2019) Zeling Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variation on a theme: investigating the structural repertoires used by ferric uptake regulators to control gene expression

(2018) Sabina Sarvan et al.   BIOMETALS

Crystal structure of Campylobacter jejuni peroxide regulator

(2018) Sabina Sarvan et al.   FEBS LETTERS

Iron and Zinc Regulate Expression of a Putative ABC Metal Transporter in Corynebacterium diphtheriae

(2018) Eric D. Peng et al.   JOURNAL OF BACTERIOLOGY

Structure–function analysis of manganese exporter proteins across bacteria

(2018) Rilee Zeinert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial zinc uptake regulator proteins and their regulons

(2018) Alevtina Mikhaylina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators

(2018) Sabina Sarvan et al.   Scientific Reports

Impact of zinc uptake regulator Zur on the sensitivity and oxidative stress response of Acinetobacter baumannii to antibiotics

(2018) T.O. Ajiboye et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

BosR Is A Novel Fur Family Member Responsive to Copper and Regulating Copper Homeostasis in Borrelia burgdorferi

(2017) Peng Wang et al.   JOURNAL OF BACTERIOLOGY

The Components of the Unique Zur Regulon of Cupriavidus metallidurans Mediate Cytoplasmic Zinc Handling

(2017) Lucy Bütof et al.   JOURNAL OF BACTERIOLOGY

Growth of Pseudomonas aeruginosa in zinc poor environments is promoted by a nicotianamine-related metallophore

(2017) Maria Chiara Mastropasqua et al.   MOLECULAR MICROBIOLOGY

O2availability impacts iron homeostasis inEscherichia coli

(2017) Nicole A. Beauchene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-dependent regulation of zinc import and export genes by Zur

(2017) Seung-Hwan Choi et al.   Nature Communications

Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline

(2017) Sébastien Lhospice et al.   Scientific Reports

Redox Sensing by Fe2+ in Bacterial Fur Family Metalloregulators

(2017) Azul Pinochet-Barros et al.   ANTIOXIDANTS & REDOX SIGNALING

Reaction of PerR with Molecular Oxygen May Assist H2O2 Sensing in Anaerobes

(2016) Ramakrishnan Sethu et al.   ACS Chemical Biology

Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120

(2016) Laura Botello-Morte et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein

(2016) Kazuo Kobayashi et al.   BIOCHEMISTRY

Quaternary Structure of Fur Proteins, a New Subfamily of Tetrameric Proteins

(2016) Julien Pérard et al.   BIOCHEMISTRY

Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferi

(2016) Zhiming Ouyang et al.   INFECTION AND IMMUNITY

The Campylobacter jejuni Ferric Uptake Regulator Promotes Acid Survival and Cross-Protection against Oxidative Stress

(2016) Momen Askoura et al.   INFECTION AND IMMUNITY

Molecular logic of the Zur-regulated zinc deprivation response in Bacillus subtilis

(2016) Jung-Ho Shin et al.   Nature Communications

Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator

(2016) Chihiro Kitatsuji et al.   Scientific Reports

Coordinated Zinc Homeostasis Is Essential for the Wild-Type Virulence of Brucella abortus

(2015) Lauren M. Sheehan et al.   JOURNAL OF BACTERIOLOGY

The DNA-Binding Protein from Starved Cells (Dps) Utilizes Dual Functions To Defend Cells against Multiple Stresses

(2015) Vlad O. Karas et al.   JOURNAL OF BACTERIOLOGY

Staphylococcus aureusPerR Is a Hypersensitive Hydrogen Peroxide Sensor using Iron-mediated Histidine Oxidation

(2015) Chang-Jun Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nickel-responsive transcriptional regulators

(2015) Francesco Musiani et al.   Metallomics

Interplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalis

(2015) Mauricio Latorre et al.   Metallomics

The Fur homologue BosR requires Arg39 to activate rpoS transcription in Borrelia burgdorferi and thereby direct spirochaete infection in mice

(2015) Laura I. Katona   MICROBIOLOGY-SGM

The Ubiquitous yybP-ykoY Riboswitch Is a Manganese-Responsive Regulatory Element

(2015) Michael Dambach et al.   MOLECULAR CELL

Manganese homeostasis and utilization in pathogenic bacteria

(2015) Lillian J. Juttukonda et al.   MOLECULAR MICROBIOLOGY

PfeT, a P1B4-type ATPase, effluxes ferrous iron and protectsBacillus subtilisagainst iron intoxication

(2015) Guohua Guan et al.   MOLECULAR MICROBIOLOGY

Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR

(2015) Bo-Eun Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Asparagine to Arginine Mutation Allows PerR to Switch from PerR Box to Fur Box

(2014) Christelle Caux-Thang et al.   ACS Chemical Biology

The FUR (ferric uptake regulator) superfamily: Diversity and versatility of key transcriptional regulators

(2014) María F. Fillat   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Analysis of the Caulobacter crescentus Zur regulon reveals novel insights in zinc acquisition by TonB-dependent outer membrane proteins

(2014) Ricardo Mazzon et al.   BMC GENOMICS

Identification of a lineage specific zinc responsive genomic island in Mycobacterium avium ssp. paratuberculosis

(2014) Elke Eckelt et al.   BMC GENOMICS

Zur (FurB) is a key factor in the control of the oxidative stress response inAnabaenasp. PCC 7120

(2014) Violeta C. Sein-Echaluce et al.   ENVIRONMENTAL MICROBIOLOGY

Specificity of Metal Sensing: Iron and Manganese Homeostasis in Bacillus subtilis

(2014) John D. Helmann   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi

(2014) Z. Ouyang et al.   MICROBIOLOGY-SGM

Differential control ofBradyrhizobium japonicumiron stimulon genes through variable affinity of the iron response regulator (Irr) for target gene promoters and selective loss of activator function

(2014) Siddharth Jaggavarapu et al.   MOLECULAR MICROBIOLOGY

BosR Functions as a Repressor of the ospAB Operon in Borrelia burgdorferi

(2014) Yanlin Shi et al.   PLoS One

Unravelling the cross-talk between iron starvation and oxidative stress responses highlights the key role of PerR (alr0957) in peroxide signalling in the cyanobacteriumNostoc PCC 7120

(2014) Fan Yingping et al.   Environmental Microbiology Reports

Structural and Mechanistic Basis of Zinc Regulation Across the E. coli Zur Regulon

(2014) Benjamin A. Gilston et al.   PLOS BIOLOGY

Single Glutamate to Aspartate Mutation Makes Ferric Uptake Regulator (Fur) as Sensitive to H2O2as Peroxide Resistance Regulator (PerR)

(2013) Aubérie Parent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unraveling the Redox Properties of the Global Regulator FurA from Anabaena sp. PCC 7120: Disulfide Reductase Activity Based on Its CXXC Motifs

(2013) Laura Botello-Morte et al.   ANTIOXIDANTS & REDOX SIGNALING

RegPrecise 3.0 – A resource for genome-scale exploration of transcriptional regulation in bacteria

(2013) Pavel S Novichkov et al.   BMC GENOMICS

Ferric Uptake Regulator-Dependent Antinitrosative Defenses in Salmonella enterica Serovar Typhimurium Pathogenesis

(2013) Maroof Husain et al.   INFECTION AND IMMUNITY

Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

(2013) Bryan Troxell et al.   INFECTION AND IMMUNITY

Identification and Characterization of Novel Helicobacter pylori apo-Fur-Regulated Target Genes

(2013) B. M. Carpenter et al.   JOURNAL OF BACTERIOLOGY

Borrelia burgdorferioxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection

(2013) Peng Wang et al.   MOLECULAR MICROBIOLOGY

The Transcriptional Regulator Np20 Is the Zinc Uptake Regulator in Pseudomonas aeruginosa

(2013) Matthew L. Ellison et al.   PLoS One

The effect of zinc limitation on the transcriptome ofPseudomonas protegens Pf-5

(2012) Chee Kent Lim et al.   ENVIRONMENTAL MICROBIOLOGY

FurA is the master regulator of iron homeostasis and modulates the expression of tetrapyrrole biosynthesis genes inAnabaenasp. PCC 7120

(2012) Andrés González et al.   ENVIRONMENTAL MICROBIOLOGY

Site-directed mutagenesis and spectral studies suggest a putative role of FurA from Anabaena sp. PCC 7120 as a heme sensor protein

(2012) Silvia Pellicer et al.   FEBS Journal

Corynebacterium glutamicumZur acts as a zinc-sensing transcriptional repressor of both zinc-inducible and zinc-repressible genes involved in zinc homeostasis

(2012) Haruhiko Teramoto et al.   FEBS Journal

The Zinc-Responsive Regulon of Neisseria meningitidis Comprises 17 Genes under Control of a Zur Element

(2012) Marie-Christin Pawlik et al.   JOURNAL OF BACTERIOLOGY

HmuP Is a Coactivator of Irr-Dependent Expression of Heme Utilization Genes in Bradyrhizobium japonicum

(2012) R. Escamilla-Hernandez et al.   JOURNAL OF BACTERIOLOGY

Characterization of the Response to Zinc Deficiency in the Cyanobacterium Anabaena sp. Strain PCC 7120

(2012) M. Napolitano et al.   JOURNAL OF BACTERIOLOGY

Peroxide-Sensing Transcriptional Regulators in Bacteria

(2012) J. M. Dubbs et al.   JOURNAL OF BACTERIOLOGY

Structure and regulon of Campylobacter jejuni ferric uptake regulator Fur define apo-Fur regulation

(2012) J. Butcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization

(2011) Gaye F. White et al.   FEBS Journal

Derepression of the Bacillus subtilis PerR Peroxide Stress Response Leads to Iron Deficiency

(2011) M. J. Faulkner et al.   JOURNAL OF BACTERIOLOGY

The Bradyrhizobium japonicum frcB Gene Encodes a Diheme Ferric Reductase

(2011) S. K. Small et al.   JOURNAL OF BACTERIOLOGY

Mur Regulates the Gene Encoding the Manganese Transporter MntH in Brucella abortus 2308

(2011) E. A. Menscher et al.   JOURNAL OF BACTERIOLOGY

Unravelling the regulatory function of FurA in Anabaena sp. PCC 7120 through 2-D DIGE proteomic analysis

(2011) Andrés González et al.   Journal of Proteomics

Mechanisms of nickel toxicity in microorganisms

(2011) Lee Macomber et al.   Metallomics

The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites

(2011) Cyril Dian et al.   MOLECULAR MICROBIOLOGY

Sequential binding and sensing of Zn(II) by Bacillus subtilis Zur

(2011) Zhen Ma et al.   NUCLEIC ACIDS RESEARCH

Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur

(2011) J.-H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BosR (BB0647) Controls the RpoN-RpoS Regulatory Pathway and Virulence Expression in Borrelia burgdorferi by a Novel DNA-Binding Mechanism

(2011) Zhiming Ouyang et al.   PLoS Pathogens

Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif

(2010) Haruto Ishikawa et al.   BIOCHEMISTRY

The multifaceted capacity of Dps proteins to combat bacterial stress conditions: Detoxification of iron and hydrogen peroxide and DNA binding

(2010) Emilia Chiancone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Zur regulon of Corynebacterium glutamicum ATCC 13032

(2010) Jasmin Schröder et al.   BMC GENOMICS

Heme-responsive DNA Binding by the Global Iron Regulator Irr fromRhizobium leguminosarum

(2010) Chloe Singleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Control of theBradyrhizobium japonicum irrGene Requires Repression by Fur and Antirepression by Irr

(2010) Thomas H. Hohle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helicobacter pylori apo-Fur regulation appears unconserved across species

(2010) Shana Miles et al.   JOURNAL OF MICROBIOLOGY

Control of bacterial iron homeostasis by manganese

(2010) S. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and Structure of the Manganese-Responsive Transcriptional Regulator ScaR,

(2009) Kate E. Stoll et al.   BIOCHEMISTRY

Characterization of Zur-dependent genes and direct Zur targets in Yersinia pestis

(2009) Yingli Li et al.   BMC MICROBIOLOGY

Characterization of a Conditional bosR Mutant in Borrelia burgdorferi

(2009) J. A. Hyde et al.   INFECTION AND IMMUNITY

The Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice

(2009) E. S. Anderson et al.   INFECTION AND IMMUNITY

Contributions of Zur-Controlled Ribosomal Proteins to Growth under Zinc Starvation Conditions

(2009) S. E. Gabriel et al.   JOURNAL OF BACTERIOLOGY

Severe Zinc Depletion ofEscherichia coli

(2009) Alison I. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

Structural characterization of the active form of PerR: insights into the metal-induced activation of PerR and Fur proteins for DNA binding

(2009) L. Jacquamet et al.   MOLECULAR MICROBIOLOGY

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete

(2009) Jenny A. Hyde et al.   MOLECULAR MICROBIOLOGY

Crystal structure of theVibrio choleraeferric uptake regulator (Fur) reveals insights into metal co-ordination

(2009) Md. Arif Sheikh et al.   MOLECULAR MICROBIOLOGY

Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition

(2009) Young Jun An et al.   NUCLEIC ACIDS RESEARCH

New insights into the role of Fur proteins: FurB (All2473) fromAnabaenaprotects DNA and increases cell survival under oxidative stress

(2008) Sara López-Gomollón et al.   BIOCHEMICAL JOURNAL

Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria

(2008) Sandra K. Small et al.   BIOMETALS

Regulation and Activity of a Zinc Uptake Regulator, Zur, in Corynebacterium diphtheriae

(2008) K. F. Smith et al.   JOURNAL OF BACTERIOLOGY

The Bradyrhizobium japonicum Irr Protein Is a Transcriptional Repressor with High-Affinity DNA-Binding Activity

(2008) I. Sangwan et al.   JOURNAL OF BACTERIOLOGY

Functional Definition and Global Regulation of Zur, a Zinc Uptake Regulator in a Streptococcus suis Serotype 2 Strain Causing Streptococcal Toxic Shock Syndrome

(2008) Y. Feng et al.   JOURNAL OF BACTERIOLOGY

PerR acts as a switch for oxygen tolerance in the strict anaerobe Clostridium acetobutylicum

(2008) Falk Hillmann et al.   MOLECULAR MICROBIOLOGY

Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein

(2008) Daouda A K Traoré et al.   Nature Chemical Biology