Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 48, Issue -, Pages 76-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2016.10.006
Keywords
Pulmonary disease, Chronic obstructive; PM2.5; Polysaccharides; Macrophages, Alveolar; Phagocytdsis; Inflammation
Funding
- National Natural Science Foundation of China [81670033]
- Science and Technology Support Program of Gansu Province [144FKCA062]
- Chinese Medicine Science and Technology Research Fund of Gansu Province [GZK-2012-25]
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Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) and Codonopsis pilosula polysaccharides (CPP) on alveolar macrophage (AM) phagocytosis and inflammation in chronic obstructive pulmonary disease (COPD) associated with exposure to particulate matter with a mean aerodynamic diameter <= 2.5 mu m (PM2.5). A mouse model of COPD was established by cigarette smoke exposure. PM2.5 exposure was performed by inhalation of a PM2.5 solution aerosol. APS and CPP were administered intra-gastrically. COPD showed defective AM phagocytosis and increased levels of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha in bronchoalveolar lavage fluid and serum. PM2.5 exposure aggravated the damage, and this effect was reversed by APS and CPP gavage. The results indicate that APS and CPP may promote defective AM phagocytosis and ameliorate the inflammatory response in COPD with or without PM2.5 exposure. (C) 2016 Elsevier B.V. All rights reserved.
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