Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 43, Issue -, Pages 83-93Publisher
ELSEVIER
DOI: 10.1016/j.etap.2016.03.001
Keywords
Benzo(a)pyrene; Depletion of mitochondrial enzymes; Histopathological lesion; Multiple organs
Funding
- Fundamental Research Funds for the Central Universities [2012jdhz48]
- Shaanxi Postdoctoral Science Foundation [18420024]
- Natural Science Basic Research Plan in Shaanxi Province of China [2014JQ4136]
- National Natural Science Foundation of China [61372151]
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Mitochondrial dysfunction has recently received considerable attention as it plays an important role in adult human pathology caused by various drugs, endogenous agents and environmental agents. Benzo(a)pyrene (BaP), is a ubiquitous environmental contaminant mainly derived from anthropogenic activity during incomplete combustion of organic materials from various sources. The present study aimed to evaluate the effects of benzo(a)pyrene (BaP) on mitochondrial enzymes in the multiple organs including liver, lung, brain, stomach and kidney. ICR mice were exposed to different doses of BaP (2.5, 5 and 10 mg/kg body weight) through oral gavage and intraperitoneal injection treatment for 13 weeks consecutively. The induced mitochondrial damage in the examined organs was assayed in terms of significant increase in lipid peroxidation (LPO) and prominent decrease in antioxidant enzymes. Non enzymatic antioxidants and Krebs cycle's enzymes were also significantly decreased in mitochondria. Additionally, BaP induced the body growth retardation and decrease in relative liver weight, increase in relative lung, stomach, kidney and brain weights, and this was further certified through histopathological lesions. Liver and lungs were more prominently damaged by BaP. The mitochondrial depletion increased in BaP dose-dependent manner. (C) 2016 Elsevier B.V. All rights reserved.
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