Journal
APPLIED RADIATION AND ISOTOPES
Volume 171, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2021.109638
Keywords
Gold nanoparticles; Monte Carlo simulations; Dose enhancement factor; Radiation therapy
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Funding
- San Antonio Medical Foundation (San Antonio, TX, USA)
- San Antonio Life Sciences Institute (San Antonio, TX, USA)
- UTSA RISE Program under National Institutes of Health (Bethesda, MD, USA) [GM060655]
- University of Texas at San Antonio Kleberg Advanced Microscopy Center
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Enhancement of dose due to gold nanoparticles in external beam radiation therapy has been quantified for energies of 6 and 18 MV through experimental and Monte Carlo simulations. The highest enhancement was observed for the 18 MV beam at the highest tested GNP concentration, with a DEF of 1.02. Increasing gold concentration and energy in the megavoltage range were found to increase DEF, with a good agreement between measured and simulated results shown across all data sets.
Dose enhancement due to gold nanoparticles (GNPs) has been quantified experimentally and through Monte Carlo simulations for external beam radiation therapy energies of 6 and 18 MV. The highest enhancement was observed for the 18 MV beam at the highest GNP concentration tested, amounting to a DEF of 1.02. DEF is shown to increase with increasing concentration of gold and increasing energy in the megavoltage energy range. The largest difference in measured vs. simulated DEF across all data sets was 0.3%, showing good agreement.
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