Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 6, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02084-20
Keywords
tigecycline resistance; colistin resistance; fosfomycin; Mcr-1.1; FosA4; Tet(X7); Egypt; Escherichia coli; chicken
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [153532]
- U.S. Department of Agriculture (USDA) [604032000-009-00]
- Ministry of Health, Labor and Welfare, Japan [H30-shokuhin-ippan-006]
Ask authors/readers for more resources
Plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains isolated from chickens in Egypt, with two fosA4-carrying IncFII plasmids detected. Transposase ISCR3 was found to be syntenic with tet(X7) in all isolates, indicating its role in the mobilization of tet(X7). This study represents the first global report of ST4-IncHI2 plasmids co-carrying tet (X7) and mcr-1.1 from chickens.
The plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains (ST10 [n = 3] and ST155 [n = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (similar to 79 kb in size) were detected. Transposase ISCR3 (IS91 family) is syntenic with tet(X7) in all isolates, suggesting its role in the mobilization of tet(X7). To our knowledge, this is the first global report of ST4-IncHI2 plasmids cocarrying tet (X7) and mcr-1.1 from chickens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
