Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 36, Issue 3, Pages 621-629Publisher
WILEY
DOI: 10.1002/etc.3383
Keywords
Estrogenic compound; Steroid transformation; Estradiol; Veterinary medicine; Synovex (R) ONE
Categories
Funding
- Zoetis
Ask authors/readers for more resources
One of the principal metabolites in cattle excreta following the administration of Synovex((R)) ONE, which contains estradiol benzoate and trenbolone acetate, is 17 alpha-estradiol. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17 alpha-estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17 alpha-[C-14]-estradiol in 2 representative water-sediment systems each under aerobic and anaerobic conditions. The same transformation products-estriol, 17 beta-estradiol, and estrone-were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of estrone and 17 beta-estradiol were determined, along with the DT50 values of 17 alpha-estradiol and the total drug (17 alpha-estradiol+17 beta-estradiol+estrone). The results indicate that 17 alpha-[C-14]-estradiol was more persistent under anaerobic conditions than under aerobic conditions and that 17 alpha-[C-14]-estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phases) and for the total residues (17 alpha- estradiol, 17 beta-estradiol, and estrone) were selected for use in modeling the environmental fate of estradiol benzoate. For aerobic degradation in the water-sediment system, the DT50 was 31.1 d, and it was 107.8 d for the anaerobic system. (C) 2016 SETAC
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available