Article
Chemistry, Applied
Alice Cariola, Madeleine El Chami, Jonathan Granatieri, Luca Valgimigli
Summary: Bakuchiol is a potent tyrosinase inhibitor for treating skin photoaging. It exhibits competitive inhibition against mushroom tyrosinase with average K-i constants of 6.71 +/- 1.23 jiM and 1.15 +/- 0.34 jiM for monophenolase and diphenolase reactions respectively. It also shows good antioxidant activity, making it a potential natural food preservative against oxidation and food-browning.
Article
Materials Science, Biomaterials
Keuna Jeon, Nesha May O. Andoy, Christian W. Schmitt, Yilei Xue, Leonie Barner, Ruby May A. Sullan
Summary: By manipulating the base systems and solution pH, researchers have influenced the formation rate and particle size of polyserotonin-based nanoparticles, improving the efficiency of nanoparticle synthesis. Synthesizing at elevated temperatures has dramatically reduced synthesis time from days to hours, making the application of PSeNP more convenient. Furthermore, the similarity between PSeNP and serotonin in free radical scavenging property demonstrates the potential of PSeNP in antioxidative therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Jael R. Neyra Recky, Mariana P. Serrano, M. Laura Dantola, Carolina Lorente
Summary: Tyrosine, an amino acid, plays a crucial role in physiological events, and its oxidation can have both beneficial and detrimental effects on biological systems. The degradation of tyrosine often begins with the loss of an electron in the presence of an electron acceptor, and DOPA is identified as a key product in this process, showing antioxidant properties.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Heba A. S. El-Nashar, Mariam I. Gamal El-Din, Lucian Hritcu, Omayma A. Eldahshan
Summary: Tyrosinase is a crucial enzyme in melanin synthesis, while excessive accumulation of melanin or overexpression of tyrosinase can lead to skin disorders. Flavonoids, a diverse natural class of compounds, exhibit antioxidant and tyrosinase inhibitor activities with a variety of mechanistic approaches.
Article
Biochemistry & Molecular Biology
Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Summary: Ten 2-mercaptobenzimidazole analogs were synthesized and found to be potent tyrosinase inhibitors and antioxidants. They effectively delayed browning of apple slices and could be potential anti-browning agents in foods.
Article
Biochemistry & Molecular Biology
Qingguan Liu, Jianjun Cheng, Xiaomeng Sun, Mingruo Guo
Summary: The study developed a method to prepare whey protein nanofibrils stabilized zein nanoparticles and investigated the properties, in vitro digestion, and antioxidant activity of the nanoparticles. The findings suggest that this new technology may be used for preparing nanoparticles of other similar hydrophobic food ingredients and provide a theoretical basis for preparation of nanoparticles as a nutrient delivery system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Soo-Yeon Ahn, Seyoung Jang, Pamidimarri D. V. N. Sudheer, Kwon-Young Choi
Summary: In this study, synthetic allomelanin was produced using wild-type Streptomyces glaucescens and recombinant Escherichia coli strains. The synthesized melanin exhibited comparable radical scavenging capacity to eumelanin and was used in cotton fabric dyeing for improved dyeing fastness. Recombinant E. coli strains expressing various enzymes were investigated for improved melanin production and novel functionalities, with chemical analysis attempted using H-NMR, FT-IR, and MALDI-TOF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Aaron D. Smith, Tanya Tschirhart, Jaimee Compton, Tiffany M. Hennessa, Eric VanArsdale, Zheng Wang
Summary: A method using a recombinant microbial system for the biosynthesis of melanin was developed, which achieved high yields and conversion rates. The use of a native copper responsive promoter for protein regulation was also investigated, providing a cost-effective alternative.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Wangchen Zhao, Ziyu Liu, Xiaoyun Liang, Siqi Wang, Jie Ding, Zhuozhu Li, Longfeng Wang, Yun Jiang
Summary: Epigallocatechin gallate loaded melanin nanoparticles (EGCG@MNPs) were prepared as eco-friendly food preservation nanomaterials with good thermal stability, antioxidant, and antibacterial activity. The nanoparticles had a uniform spherical structure below 100 nm in diameter, and exhibited superior thermal stability and antioxidant properties. EGCG@MNPs showed higher scavenging ratios for DPPH and ABTS(+) compared to pure EGCG, with lower minimum inhibitory concentration and minimum bactericidal concentration for Escherichia coli and Staphylococcus aureus.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Yinpeng Ma, Piqi Zhang, Xiaodong Dai, Xiuge Yao, Shuyang Zhou, Qingfang Ma, Jianing Liu, Shuang Tian, Jianan Zhu, Jiechi Zhang, Xianghui Kong, Yihong Bao
Summary: This study investigated the effects of alkali-soluble pH, acid precipitation pH, and microwave time on the extraction yield of Auricularia heimuer melanin (AHM) from fermentation. The optimized extraction conditions were alkali-soluble pH of 12.3, acid precipitation pH of 3.1, and microwave time of 53 min, resulting in an AHM extraction yield of 0.4042%. AHM exhibited similar absorption properties to melanin from other sources and showed strong free radical scavenging activities.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Zekai Gou, Zhibo Peng, Shiyu Wang, Liuyang Chen, Zhicong Ma, Yifan Kang, Liang Sun, Rui Wang, Hong Xu, Yian Gu, Dafeng Sun, Peng Lei
Summary: In this study, SPG-producing strains of S. commune from different provinces in China were screened. A candidate strain (NTU-1) with a high SPG yield was chosen, and the fermentation conditions were optimized. The highest reported SPG concentration of 21.3 g/L was obtained in a 5-L bioreactor with a reduced fermentation cycle of five days.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hernan Mauricio Rivera, Esther Natalia Munoz, Daniel Osuna, Mauro Florez, Michael Carvajal, Luis Alberto Gomez
Summary: The study evaluated changes in microRNA expression and identified several miRNAs related to differential pigmentation and reduced proliferation in B16F1 melanoma cells exposed to 5-Brd-2'-dU and L-Tyr. The results suggested a coordinated and reciprocal co-expression of specific microRNAs with molecular targets involved in melanogenesis, cell cycle control, and senescence. These findings provide insights into the molecular basis of pigmentation changes and decreased proliferation in melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Di Zhang, Xianrui Chen, Nitong Bu, Liying Huang, Huanglong Lin, Lizhen Zhou, Ruojun Mu, Lin Wang, Jie Pang, Andrea Gomez-Zavaglia
Summary: In this study, a novel nanoscale delivery system for quercetin was successfully constructed using melanin nanoparticles. The system showed improved thermal stability, antioxidant properties, and antibacterial capability. It also exhibited NIR/pH dual-responsive drug release behavior.
Article
Biochemistry & Molecular Biology
Zhi Li, Hui Heng, Qiqian Qin, Lanchun Chen, Yuedi Wang, Zeyang Zhou
Summary: This study reports the presence of melanin produced by Ascosphaera apis, which exhibits antioxidant activity and metal ion chelating properties, and is located on the spore wall. However, melanin does not enhance the virulence of A. apis spores.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Food Science & Technology
Juanjuan Tian, Qingyan Mao, Mingsheng Dong, Xiaomeng Wang, Xin Rui, Qiuqin Zhang, Xiaohong Chen, Wei Li
Summary: Soybean whey was utilized as a fermentation substrate for Lacticaseibacillus plantarum 70810 to produce an exopolysaccharide (LPEPS-1) with antioxidant properties. LPEPS-1 was found to contain mannose, glucose, and galactose with specific molar ratios, and exhibited strong scavenging activity against radicals and chelating ability on ferrous ion. The study suggests that soybean whey can be a viable source for producing beneficial polysaccharides for functional foods.
Article
Multidisciplinary Sciences
Sara Ghashghaei, Zahra Etemadifar, Mohammad Reza Mofid
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2018)
Article
Environmental Sciences
Zahra Etemadifar, Shekoofeh Sadat Etemadzadeh, Giti Emtiazi
GEOMICROBIOLOGY JOURNAL
(2019)
Article
Materials Science, Biomaterials
M. Shahshahanipour, B. Rezaei, Ali A. Ensafi, Zahra Etemadifar
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Engineering, Environmental
Yasaman Boroumand, Amir Razmjou, Parisa Moazzam, Fereshteh Mohagheghian, Ghazaleh Eshaghi, Zahra Etemadifar, Mohsen Asadnia, Rasoul Shafiei
JOURNAL OF WATER PROCESS ENGINEERING
(2020)
Article
Microbiology
Sharareh Harirchi, Zahra Etemadifar, Amir Mahboubi, Fatemeh Yazdian, Mohammad J. Taherzadeh
CURRENT MICROBIOLOGY
(2020)
Article
Agricultural Engineering
Sharareh Harirchi, Zahra Etemadifar, Fatemeh Yazdian, Mohammad J. Taherzadeh
BIORESOURCE TECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
S. Eskandari, Z. Etemadifar
Summary: This study successfully isolated a bacterium with high yield of melanin from soil and obtained high production of melanin by optimizing inexpensive waste sources. The extracted melanin showed high radical scavenging activity and sun protection factor.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Ecology
Fatemeh Elmi, Zahra Etemadifar, Giti Emtiazi
Summary: A extremophile bacterium isolated from sandy soil exhibited high urease activity and the ability to produce calcium carbonate. Identified as Bhargavaea cecembensis, this strain predominantly produced irregular vaterite and aggregated nanocalcite crystals. The strain showed high tolerance to extreme conditions and high cell viability after desiccation stress, making it a suitable candidate for bio-cementation.
Article
Multidisciplinary Sciences
Fatemeh Elmi, Zahra Etemadifar, Giti Emtiazi
Summary: Microbially induced calcium carbonate precipitation is a common process in nature, and the isolated strains in this study demonstrated resistance to extreme conditions, such as high salinity, acidity and alkalinity, as well as high temperature and desiccation stress.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2022)
Review
Microbiology
Sharareh Harirchi, Taner Sar, Mohaddaseh Ramezani, Habibu Aliyu, Zahra Etemadifar, Seyed Ali Nojoumi, Fatemeh Yazdian, Mukesh Kumar Awasthi, Mohammad J. Taherzadeh
Summary: This paper introduces the important applications of the genus Bacillus and its related genera in biotechnology and industry, and discusses the taxonomical complexities of the order Bacillales. Moreover, it emphasizes the biotechnological usage of some engineered strains of the order Bacillales. The elucidation of novel taxa, their metabolic pathways, and growth conditions would drive industrial processes towards upgraded functionality based on microbial nature.
Article
Multidisciplinary Sciences
Atefeh Salehi Bakhtiyari, Zahra Etemadifar, Matia Sadat Borhani
SN APPLIED SCIENCES
(2020)
Article
Fisheries
J. Cheraghpour, Z. Etemadifar, S. Afsharzadeh, N. Bahador
IRANIAN JOURNAL OF FISHERIES SCIENCES
(2020)
Article
Environmental Sciences
Javad Cheraghpour, Zahra Etemadifar, Saeed Afsharzadeh, Nima Bahador
FRESENIUS ENVIRONMENTAL BULLETIN
(2018)
Article
Mining & Mineral Processing
S. S. Etemadzadeh, G. Emtiazi, Z. Etemadifar
JOURNAL OF MINING AND ENVIRONMENT
(2018)