Review
Chemistry, Inorganic & Nuclear
Caiping Ding, Tianbing Ren
Summary: Near infrared (NIR) fluorescent probes have advantageous features including low background interference, strong tissue penetration, and minimal tissue damage. This paper provides a summary and discussion on the various types and properties of fluorophores used in the design of NIR fluorescent probes. It also discusses the latest research achievements in detecting and imaging reactive oxygen species, reactive nitrogen, and active sulfur in cells or in vivo. Additionally, a concise overview of the future development of NIR molecular fluorescence probes is proposed based on existing research, offering a reference for current research directions.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Engineering, Environmental
Feng Liu, Biao Huang, Tao Tang, Fanjie Wang, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: Researchers developed a fluorescent nanozyme by doping Mn atoms into PbS/CdS quantum dots, which showed excellent antioxidant activity and could effectively scavenge ROS, thus providing neuroprotective effects for traumatic brain injury treatment. Additionally, the nanozyme exhibited exceptional NIR-IIb fluorescence performance, allowing for dynamic monitoring of the blood-brain barrier status to guide precise treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Kanyi Pu
Summary: Near-infrared (NIR) fluorescence imaging shows great potential in both basic biomedical research and clinical practice, especially in the diagnosis of nephron-urological diseases. The development of molecular probes has improved detection specificity and contrast enhancement in imaging.
Article
Spectroscopy
Zhengbing Zhou, Xiao Yuan, Da Long, Manhua Liu, Kun Li, Yongmei Xie
Summary: A lysosomal-targeted near infrared fluorescent probe with high sensitivity towards reactive oxygen species (ROS) was developed, showing different response activity towards H2O2, · OH, and HClO. It has been successfully used for ROS detection and imaging in cells and in vivo.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Engineering, Biomedical
Dongrui Yin, Chenzhi Yao, Ying Chen, Zuyang He, Peng Yu, Xingwen Sun, Shangfeng Wang, Fan Zhang
Summary: This study reports a novel near-infrared fluorescent probe that can highly sensitively and selectively detect hypochlorous acid in the living body, and has potential application in studying inflammatory diseases. The probe achieves fluorescence turn-on through a chemical reaction and can be used for intracellular and in vivo imaging. This research provides new insights into hypochlorous acid and ferrocene chemistry, and extends the use of fluorescent strategies in near-infrared biosensing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yang Zhong, Lulu Yang, Yunyun Zhou, Juanjuan Peng
Summary: Liver injury-related diseases have attracted attention due to their unpredictability, acute onset, and severe consequences. Fluorescence imaging techniques have been used for the diagnosis of liver injury, offering comprehensive information about the lesion site. This article provides a summary and discussion of the design strategies and applications of fluorescent biosensors responsive to biomarkers involved in liver injury.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Qian Wu, Qian-Hui Zhou, Wei Li, Tian-Bing Ren, Xiao-Bing Zhang, Lin Yuan
Summary: This study developed a highly sensitive fluorescent probe NIR-beta gal-2 for the accurate diagnosis of breast carcinoma and differentiating tumors from normal tissues during surgery. The probe demonstrated superior sensitivity, affinity, and catalytic efficiency for fi-galactosidase. The probe was successfully applied for intraoperative guided excision of breast tumors and showed promising results for prognostic recovery.
Article
Chemistry, Multidisciplinary
Xin Wei, Jingsheng Huang, Chi Zhang, Cheng Xu, Kanyi Pu, Yan Zhang
Summary: Researchers have synthesized a highly bright near-infrared chemiluminophore through molecular engineering of the electron-withdrawing group. This chemiluminophore shows a 3 to 5-fold higher quantum yield compared to existing ones. By combining it with a cathepsin B-responsive moiety, an activatable chemiluminescence probe has been developed for real-time detection of deeply buried tumor tissues and accurate chemiluminescence-guided laparotomy in living mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Jun-Tao Chen, Si-Si Chen, Zhi-Qing Wang, Guo Yu, Guo-Jiang Mao, Junjie Fei, Chun-Yan Li
Summary: This study proposes a near-infrared fluorescent nanoprobe based on a zeolitic imidazole framework for detecting the level of adenosine triphosphate (ATP) in cells, which is of great significance for various disease models.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Ya-Lin Qi, Yun-Zhan Li, Ming-Jun Tan, Fang-Fang Yuan, Niren Murthy, Yong-Tao Duan, Hai-Liang Zhu, Sheng-Yu Yang
Summary: In recent years, there has been great interest in the development of organic near-infrared (NIR) ratiometric fluorescent probes. Traditional intensity-based probes lack an internal standard method, resulting in unreliable and inaccurate detection signals as well as an inability to achieve quantitative determination of analytes. Smart dual emission probes with built-in correction ability have overcome the limitations of single channel fluorescent probes and enable reliable quantitative image analysis. Moreover, fluorescent chemosensors in the NIR window offer advantages such as high signal-to-noise ratio, low tissue damage, and deep tissue penetration. The combination of the advantages of ratiometric fluorescent probes and single-intensity-based NIR probes in NIR ratiometric fluorescent probes has led to their widespread application in biomedical research and clinical practice. This review provides a systematic summary of the recent advances (2020-2022) in this field, discussing the design strategies, sensing mechanisms, and bioapplications of these intelligent fluorescent probes. The challenges and prospects in this promising field are also addressed, with the anticipation that this work will inspire the development of organic NIR ratiometric fluorescent probes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Chemistry, Analytical
Wei Zhang, Jie Ren, Jun Lu, Ping Li, Wen Zhang, Hui Wang, Bo Tang
Summary: The relationship between reactive oxygen species (ROS) and levels of protein phosphorylation was investigated using a metal-organic framework-based fluorescent nanoprobe. The probe achieved simultaneous recognition of ROS and phosphorylation sites, improving imaging sensitivity with the two-photon property of the ROS recognition unit. This work provides feasible fluorescence tools for revealing the pathogenesis of diseases.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mei-Jia Hou, Zhi-Qing Wang, Jun-Tao Chen, Zhi-Ke Tan, Guo-Jiang Mao, Junjie Fei, Chun-Yan Li
Summary: This study developed a fluorescent nanoprobe for sequential detection of ATP and ONOO-, showing potential for accurate cancer diagnosis by distinguishing cancer cells from normal cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Colman Moore, Yong Cheng, Natalia Tjokro, Brendan Zhang, Matthew Kerr, Mohammed Hayati, Kai Chiao Joe Chang, Nisarg Shah, Casey Chen, Jesse Jokerst
Summary: We report a dual-modal fluorescent and photoacoustic imaging probe for the detection of gingipain proteases secreted by P. gingivalis. The probe showed significant photoacoustic enhancement and fluorescence activation, with low detection limits. It demonstrated good diagnostic efficacy in porcine jaws and gingival crevicular fluid samples from periodontal disease subjects. Additionally, photoacoustic imaging of the probe was achieved in murine brains ex vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
