Article
Neurosciences
Jasmine Caulfield, Allison M. Ching, Erin M. Cover, Avery August, Timothy Craig, Helen M. Kamens, Sonia A. Cavigelli
Summary: Allergic asthma, typically controlled with inhaled corticosteroids (ICS), is the leading chronic health condition for youth under 18 years of age. Significant brain maturation occurs during the peri-adolescent period. Studies indicate that chronic inflammation and corticosteroid medications increase the risk for developing anxiety-related symptoms.
PSYCHOPHARMACOLOGY
(2021)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Giovanni Cerimoniale, Paolo Becherucci, Maria Carmen Verga, Giuseppe Di Mauro, Luciana Indinnimeo, Alberto Villani, Mariangela Tosca, Gian Luigi Marseglia, Marzia Duse, Paolo Biasci, Mattia Doria, Diego Peroni, Giorgio Piacentini, Maria Di Cicco, Gabriella Pozzobon, Riccardo Lubrano
Summary: A national consensus document on inhaled corticosteroids (ICS) use in childhood has been released in Italy. This study aimed to gather information on pediatricians' ICS prescription habits. The study found good adherence to international guidelines for allergic rhinitis management, but there is room for improvement in the management of asthma. Future surveys on a larger sample size may help analyze differences in prescription habits based on pediatricians' work settings and geographical distribution.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pediatrics
Megha Goyal, Vishal Guglani, Pankaj Kumar, Shivani Randev
Summary: A study compared the effects of once-daily versus twice-daily administration of inhaled budesonide on morning peak expiratory flow rate and clinical asthma control in children. The results showed that once-daily administration was noninferior to twice-daily administration in terms of efficacy.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Allergy
Pontus Mertsch, Jeremias Goetschke, Julia Walter, Carlo Muemmler, Alessandro Ghiani, Ulrike Schuermann, Rosemarie Kiefl, Rudolf Maria Huber, Juergen Behr, Nikolaus Kneidinger, Katrin Milger
Summary: The study analyzed the impact of high altitude environment on lung function in mild seasonal asthmatics, finding that using inhaled corticosteroid treatment can prevent the decrease in FEV1 caused by high altitude factors, while untreated asthmatics experience a reduction in FEV1 in such conditions.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Allergy
Javier Perez-Garcia, Mario Gonzalez-Carracedo, Antonio Espuela-Ortiz, Jose M. Hernandez-Perez, Ruperto Gonzalez-Perez, Olaia Sardon-Prado, Elena Martin-Gonzalez, Elena Mederos-Luis, Paloma Poza-Guedes, Paula Corcuera-Elosegui, Ariel Callero, Inmaculada Sanchez-Machin, Javier Korta-Murua, Jose A. Perez-Perez, Jesus Villar, Maria Pino-Yanes, Fabian Lorenzo-Diaz
Summary: This study investigated the association between the upper-airway microbiome and asthma exacerbations despite treatment with inhaled corticosteroids (ICS) in 250 asthma patients. The results showed that case subjects had lower bacterial diversity in nasal and saliva samples compared to control subjects. Additionally, the salivary microbiome was identified as a potential biomarker for asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Health Care Sciences & Services
Natalia Hernandez-Pacheco, Mario Gorenjak, Jiang Li, Katja Repnik, Susanne J. Vijverberg, Vojko Berce, Andrea Jorgensen, Leila Karimi, Maximilian Schieck, Lesly-Anne Samedy-Bates, Roger Tavendale, Jesus Villar, Somnath Mukhopadhyay, Munir Pirmohamed, Katia M. C. Verhamme, Michael Kabesch, Daniel B. Hawcutt, Steve Turner, Colin N. Palmer, Kelan G. Tantisira, Esteban G. Burchard, Anke H. Maitland-van der Zee, Carlos Flores, Uros Potocnik, Maria Pino-Yanes
Summary: This study aimed to identify novel genetic markers involved in ICS response in asthma through a GWAS, and found suggestive association of the SNP rs1166980 in the ROBO2 gene with the change in lung function. It also validated the association of PDE10A-T with ICS response as described in a previous study. These results suggest that ROBO2 could be a potential novel locus for ICS response in Europeans.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Wenli Shang, Guizuo Wang, Yan Wang, Dong Han
Summary: This study aimed to evaluate the safety of long-term use of ICS in patients with asthma through a systematic review and meta-analysis. The results showed that, apart from mild local adverse events, the long-term use of ICS was safe for patients with asthma.
CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Arnaud Bourdin, Alberto A. Papi, Jonathan Corren, J. Christian Virchow, Megan S. Rice, Yamo Deniz, Michel Djandji, Paul Rowe, Ian D. Pavord
Summary: Dupilumab significantly reduced severe exacerbations and improved lung function and asthma control in patients with type 2-high asthma on high-dose ICS at baseline.
Article
Allergy
Ahmed Edris, Emmely W. de Roos, Michael J. McGeachie, Katia M. C. Verhamme, Guy G. Brusselle, Kelan G. Tantisira, Carlos Iribarren, Meng Lu, Ann Chen Wu, Bruno H. Stricker, Lies Lahousse
Summary: Genetic variants in CRHR1 and TBXT genes were found to be associated with poor and improved ICS response in adults with asthma, respectively. These associations may indicate specific endotypes that could potentially predict exacerbation risk and response to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Chemistry, Multidisciplinary
Elzbieta Dembowska, Aleksandra Jaron, Karolina Skoczek-Szlosser, Ewa Gabrysz-Trybek, Joanna Bladowska, Grzegorz Trybek
Summary: Asthma, a common allergic disease, affects both general health and oral health. This study observed the oral health status of 120 adult patients aged 18 to 71, finding significantly deeper pockets in the lateral segments of the dentition in all study groups, especially in the bronchial-only group. However, there was no significant worsening of periodontal status in asthma patients treated with inhalation, regardless of baseline periodontal status. The history of asthma and the use of inhaled corticosteroids (ICS) have an impact on patients' periodontal status.
APPLIED SCIENCES-BASEL
(2022)
Article
Pediatrics
Shingo Yamada, Takao Fujisawa, Mizuho Nagao, Hiroshi Matsuzaki, Chikako Motomura, Hiroshi Odajima, Toshinori Nakamura, Takanori Imai, Ken-ichi Nagakura, Noriyuki Yanagida, Masatoshi Mitomori, Motohiro Ebisawa, Shigenori Kabashima, Yukihiro Ohya, Chizu Habukawa, Minako Tomiita, Masahiro Hirayama
Summary: This study aims to identify clinical factors associated with low or declining lung function in children with asthma during treatment. The results show that poor asthma control, the use of long-acting beta2 agonists, and lower height during the ages of 13-15 are associated with unfavorable lung function changes. On the other hand, the use of inhaled corticosteroids during the ages of 10-12 and high-dose use during the ages of 13-15 are associated with favorable lung function changes.
Article
Physiology
Sarah Basin, Simon Valentin, Silvia Demoulin-Alexikova, Bruno Demoulin, Laurent Foucaud, Delphine Gerard, Celso Pouget, Edem Allado, Bruno Chenuel, Mathias Poussel
Summary: This study evaluated the impact of inhaled corticosteroids on cough reflex during artificial limb exercise in an animal model of eosinophilic airway inflammation. The results showed that inhaled corticosteroids were able to restore desensitization of the cough reflex, suggesting potential benefits for managing exercise-induced cough in asthma patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Allergy
Luis Moral, Teresa Toral, Ana Gilabert, Ares Sanchez, Juan Francisco Silvestre, Francisco Manuel Marco
Summary: Severe cutaneous adverse reactions (SCARs) frequently occur in pediatric patients with acute illnesses. Drug provocation test (DPT) is usually contraindicated in these cases, but it may be considered after careful evaluation and sequential study. This study confirms ibuprofen tolerance in three pediatric patients with SCAR.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Allergy
Annick Barbaud, Lene Heise Garvey, Alessandra Arcolaci, Knut Brockow, Francesca Mori, Cristobalina Mayorga, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Luis Moral, Giovanna Zanoni, Mauro Pagani, Angele Soria, Maja Jost, Jean-Christoph Caubet, Abreu Carmo, Al-Ahmad Mona, Alberto Alvarez-Perea, Sevim Bavbek, Biagioni Benedetta, M. Beatrice Bilo, Natalia Blanca-Lopez, Herrera Gador Bogas, Alessandro Buonomo, Gianfranco Calogiuri, Giulia Carli, Josefina Cernadas, Gabriele Cortellini, Gulfem Celik, Semra Demir, Inmaculada Dona, Adile Berna Dursun, Bernadette Eberlein, Emilia Faria, Bryan Fernandes, Tomaz Garcez, Ignacio Garcia-Nunez, Radoslaw Gawlik, Asli Gelincik, Eva Gomes, Jimmy H. C. Gooi, Martine Grosber, Theo Gulen, Florence Hacard, Cyrille Hoarau, Christer Janson, Sebastian L. Johnston, Lukas Joerg, Secil Kepil Ozdemir, Ludger Klimek, Mitja Kosnik, Marek L. Kowalski, Semanur Kuyucu, Violeta Kvedariene, Jose Julio Laguna, Carla Lombardo, Susana Marinho, Hans Merk, Elisa Meucci, Martine Morisset, Rosa Munoz-Cano, Francesco Murzilli, Alla Nakonechna, Florin-Dan Popescu, Grzegorz Porebski, Anna Radice, Frederico S. Regateiro, Heike Rockmann, Antonino Romano, Ravishankar Sargur, Joaquin Sastre, Kathrin Scherer Hofmeier, Lenka Sedlackova, Marta Sobotkova, Ingrid Terreehorst, Regina Treudler, Jolanta Walusiak-Skorupa, Bettina Wedi, Stefan Wohrl, Mihael Zidarn, Torsten Zuberbier, Ioana Agache, Maria J. Torres
Summary: Background anaphylaxis after COVID-19 vaccination is rare, and its management is not standardized. The authors propose allergy evaluation and prick test for individuals with specific allergy histories, aiming to improve the understanding and management of anaphylaxis to COVID-19 vaccines and facilitate vaccination for people with allergy history.
Article
Allergy
J. Valverde-Molina, M. Fernandez-Nieto, J. Torres-Borrego, J. Lozano Blasco, I de Mir-Messa, M. Blanco-Aparicio, A. Nieto, J. Figuerola Mulet, A. L. Moure, M. G. Sanchez-Herrero, S. Sanchez-Garcia
Summary: The study aimed to assess the consensus among a multidisciplinary expert panel on the transition of adolescents with severe asthma from pediatric to adult care. A 61-item survey was conducted using a 2-round Delphi process, involving 98 experts. Consensus was reached for 42 items (70%). The experts identified the main goal during the transition as promoting autonomy in managing severe asthma and prescribed treatments, and agreed on the importance of developing an individualized plan and identifying factors associated with the home environment.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Primary Health Care
Arwa Abdel-Aal, Karin Lisspers, Sian Williams, Peymane Adab, Rachel Adams, Dhiraj Agarwal, Amanda Barnard, Izolde Bouloukaki, Job F. M. van Boven, Niels Chavannes, Andrew P. Dickens, Frederik van Gemert, Mercedes Escarrer, Shamil Haroon, Alex Kayongo, Bruce Kirenga, Janwillem W. H. Kocks, Daniel Kotz, Chris Newby, Cliodna McNulty, Esther Metting, Luis Moral, Sophia Papadakis, Hilary Pinnock, David Price, Dermot Ryan, Sally J. Singh, Jaime Correia de Sousa, Bjorn Stallberg, Stanley J. Szefler, Stephanie J. C. Taylor, Ioanna Tsiligianni, Alice Turner, David Weller, Osman Yusuf, Aizhamal K. Tabyshova, Rachel E. Jordan
Summary: Respiratory diseases are a significant global health issue where primary care plays a key role in prevention, diagnosis, and treatment. The research identified a need for enhanced training for primary care clinicians, guidelines specifically relevant to primary care, empowerment of patients for self-management, and the role of multidisciplinary healthcare teams.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Roser Ayats-Vidal, Amalui Vasquez-Perez, Miguel Gallego-Diaz, Antoni Rosell, Laura Valdesoiro-Navarrete, Rachid Tazi-Mezalek
Summary: We report a case of delayed diagnosis of foreign body (FB) aspiration in a 9-year-old boy. The FB was successfully extracted after unsuccessful attempts with flexible forceps, by using nitrous oxide cryotherapy to remove the associated inflamed granulation tissue. Early diagnosis is crucial in minimizing granulation tissue development.
RESPIRATORY MEDICINE CASE REPORTS
(2022)
Article
Allergy
Laura Valdesoiro-Navarrete, Maria Esther Leon, Marcos Rodriguez, Martina Indiveri, Roser Ayats, Helena Larramona, Miguel Garcia Gonzalez, Oscar Asensio de la Cruz, Montserrat Bosque Garcia
Summary: This study aimed to analyze the safety and efficacy of combining omalizumab (OM) with allergen-specific immunotherapy (AIT) in children with severe asthma. The results showed that the combined treatment of OM and AIT was safe and effective, improving asthma control and lung function in pediatric patients.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Allergy
Luis Moral, Sara Latorre, Teresa Toral, Nuria Marco, Francisco Canals, Maria Jose Fornies, Maria Cristina Gonzalez, Belen Garcia-Aviles
Summary: This study retrospectively analyzed presumedly positive or inconclusive drug provocation tests conducted in pediatric allergy clinics and evaluated the need for repeat tests and their outcomes. The study found that the positive predictive value of drug provocation tests may be lower than expected, and therefore, a second confirmatory test is recommended within a few weeks or months.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Allergy
Juan Carlos Miralles-Lopez, Ruben Andujar-Espinosa, Francisco Javier Bravo-Gutierrez, Manuel Castilla-Martinez, Isabel Flores-Martin, Maria Loreto Alemany-Frances, Manuel Jose Pajaron-Fernandez, Ana Mora-Gonzalez, Sheila Cabrejos-Perotti, Zouhair El-Molaka, Jose Meseguer-Arce, Maria Jesus Aviles-Ingles, Jose Valverde-Molina, Virginia Perez-Fernandez
Summary: This study describes the super-responders to benralizumab in a series of 79 patients with severe eosinophilic asthma and compares them to non super-responders. The results show that almost two-thirds of the patients were super-responders and 36% had a complete response. Super-responders were associated with older age, higher eosinophils count, nasal polyposis as comorbidity, and less severe disease at baseline.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Pediatrics
Carolina Diaz-Garcia, Jose Valverde-Molina, Antonio Martinez-Gimeno, Juan L. Anton-Pacheco Sanchez
Summary: The aim of this study was to analyze the psychometric performance of the TAPQOL questionnaire in measuring the global quality of life in children with central airway obstruction. The results showed that the TAPQOL questionnaire is a valid tool for measuring the health-related quality of life in patients with CAO.
PEDIATRIC PULMONOLOGY
(2023)
Editorial Material
Allergy
M. Castilla-Martinez, R. Andujar-Espinosa, I Flores-Martin, M. H. Reyes Cotes, S. Cabrejos-Perotti, J. C. Miralles-Lopez, A. Carbonell-Martinez, F. J. Bravo-Gutierrez, J. Valverde-Molina, V Perez-Fernandez
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Jose Valverde-Molina, Luis Garcia-Marcos
Summary: The importance of the microbiome and the gut-lung axis in the development and persistence of asthma is currently being investigated. The colonization of microbes in the first three years of life, especially the first hundred days, plays a crucial role in determining health. Early microbial dysbiosis caused by factors such as cesarean delivery, artificial lactation, and antibiotic therapy have been associated with the later development of asthma in children.
Article
Respiratory System
Luis Gonzalez-de Paz, Laura Valdesoiro-Navarrete, Josep Roma, Esther Blat-Guimera, Jaume Benavent-Areu, Joan Bartra, Antoni Siso-Almirall
Summary: This study investigated the prevalence of asthma and allergies in children under 14 years old in Spain and their impact on health-related quality of life, activities, healthcare utilization, and environmental and household exposure risk factors. The results showed that asthma and allergies have a significant impact on children's daily life and healthcare utilization.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Pediatrics
Catalina Lizano-Barrantes, Olatz Garin, Alexandra Lelia Dima, Karina Mayoral, Angels Pont, Eva Maria Ortiz, Maria Araceli Caballero-Rabasco, Manuel Praena-Crespo, Laura Valdesoiro-Navarrete, Maria Teresa Guerra, Alberto Bercedo-Sanz, Gimena Hernandez, Camila Maroni, Ines de Mir, Maria Angeles Carrasco, Marta Ortega, Alberto Servan, Jose Antonio Castillo, Eva Tato, Montse Ferrer, A. R. C. A. Grp ARCA Grp
WORLD JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Olaia Sardon-Prado, Carolina Diaz-Garcia, Paula Corcuera-Elosegui, Javier Korta-Murua, Jose Valverde-Molina, Manuel Sanchez-Solis
Summary: Recognition of phenotypic variability in pediatric asthma allows for a more personalized therapeutic approach. Biologic therapies for children with severe asthma are becoming more relevant in this sense.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Respiratory System
Karina Mayoral, Catalina Lizano-Barrantes, Victor Zamora, Angels Pont, Carme Miret, Cristina Barrufet, M. Araceli Caballero-Rabasco, Manuel Praena-Crespo, Alberto Bercedo, Laura Valdesoiro-Navarrete, Maria Teresa Guerra, Yolanda Pardo, Ma Jose Martinez Zapata, Olatz Garin, Montse Ferrer
Summary: This study aimed to assess the impact of montelukast on pediatric patients with asthma/allergic rhinitis and found that montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms. These findings are consistent with current asthma treatment guidelines.
EUROPEAN RESPIRATORY REVIEW
(2023)