Article
Cell Biology
Jingzhou Zhang, Xiujuan Xu, Junfeng Yin, Jiaqi Tang, Nan Hu, Yidong Hong, Ziyan Song, Baoxiang Bian, Fenglei Wu
Summary: Long non-coding RNAs, such as OGFRP1, play a crucial role in gastric cancer research. High expression of OGFRP1 promotes tumor progression by activating the AKT/mTOR pathway. Targeting OGFRP1 could be a potential new strategy for clinical treatment of human gastric cancer.
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jiahuang Qiu, Yifan Guo, Shunhao Wang, Quanzhong Ren, Zheng Dong, Ming Gao, Juan Ma, Shuguang Chen, Sijin Liu
Summary: In this study, the transcriptome profiles of lncRNAs were compared between primary breast cancer 4T1 cells and highly metastatic 4T1-LG12 cells. It was found that many differentially expressed lncRNAs were strongly correlated with the metastatic propensity of 4T1-LG12 cells. Among them, lncRNA-45, a newly identified lncRNA, was the most upregulated lncRNA transcribed by an internal region within the Rptor gene. Functional investigation revealed that lncRNA-45 played a regulatory role in the epithelial-to-mesenchymal transition process of breast cancer cells and its knockdown significantly suppressed the invasive capability of 4T1-LG12 cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Qiong Wu, Jiali Ma, Jue Wei, Wenying Meng, Yugang Wang, Min Shi
Summary: FOXD1-AS1 aggravates gastric cancer progression and chemoresistance by promoting FOXD1 translation through the PIK3CA/PI3K/AKT/mTOR signaling pathway. These findings offer a potential novel target for treating gastric cancer patients, especially those with cisplatin resistance.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen
Summary: This study aimed to explore the influence of endothelial cell-specific molecule 1 (ESM1) expression on colorectal cancer (CRC) cells and analyze its possible mechanism. ESM1 overexpression was found to promote tumor angiogenesis in CRC and accelerate tumor progression. The study also revealed that ESM1 may promote angiogenesis in CRC by activating the PI3K/Akt/mTOR pathway.
Article
Biotechnology & Applied Microbiology
Qiong Wu, Jiali Ma, Jue Wei, Wenying Meng, Yugang Wang, Min Shi
Summary: SNHG11 serves as an oncoIncRNA in gastric cancer by promoting oncogenic autophagy and malignant behaviors through both the miR-483-3p/miR-1276 pathway and the Wnt/β-catenin pathway. Its upregulation is transcriptionally induced by TCF7L2 and may be a potential prognostic and therapeutic target for gastric cancer.
Article
Oncology
Kun Jiang, Li-zhe Xu, Jin-zhuo Ning, Fan Cheng
Summary: This study aimed to investigate the expression of FAP and its clinical implication in ccRCC. Computational tools analysis of gene databases revealed that FAP levels were significantly elevated in ccRCC. Higher expression levels of FAP were associated with poorer prognoses in ccRCC patients, and FAP may serve as a reliable biomarker for the diagnosis and prognosis of ccRCC.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin
Summary: SPOCK1 plays a crucial role in breast cancer progression by promoting cell proliferation and metastasis, making it a promising clinical therapeutic target for preventing the progression of breast cancer.
Article
Oncology
Xiangyuan Luo, Mengdie Cao, Fan Gao, Xingxing He
Summary: YTHDF1 is overexpressed in HCC and associated with HCC grade. It promotes the growth of HCC cells by activating the PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition (EMT) to enhance migration and invasion.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell Biology
Hui Li, Bingxin Guan, Sen Liu, Haiting Liu, Lin Song, Guohao Zhang, Ruinan Zhao, Chengjun Zhou, Peng Gao
Summary: Gastric cancer is a highly heterogeneous disease with poor prognosis. Protein tyrosine phosphatases, specifically PTPN14, play a vital role in gastric cancer by promoting cell proliferation, migration, and invasion.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Xiaoyu Yi, Chao Zhang, Baojie Liu, Guojun Gao, Yaqi Tang, Yongzheng Lu, Zhifang Pan, Guohui Wang, Weiguo Feng
Summary: This study identified the role of RPL22L1 in the progression of prostate cancer (PCa). It was found that the expression of RPL22L1 was significantly higher in PCa tissues compared to normal prostate tissues, and it promoted the proliferation and invasion of PCa cells by activating the PI3K/Akt/mTOR pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Biochemistry & Molecular Biology
Fei Qi, Zhong-Dong Lv, Wen-Di Huang, Shan-Chen Wei, Xin-Min Liu, Wei-Dong Song
Summary: This study aimed to elucidate the function and potential mechanisms of TUG1 in IPF progression. The results showed that TUG1 played a role in promoting fibrosis and inflammation in IPF, and it also activated the PI3K/Akt/mTOR pathway and induced autophagy to suppress pulmonary fibrosis.
Article
Cell Biology
Danping Sun, Mingxiang Zhang, Meng Wei, Zhaoyang Wang, Wen Qiao, Peng Liu, Xin Zhong, Yize Liang, Yuanyuan Chen, Yadi Huang, Wenbin Yu
Summary: The study investigated the relationship between dyslipidemia and interleukin-enhancer binding factor 3 (ILF3) in gastric cancer, and suggested that ox-LDL promotes ILF3 overexpression to regulate cancer progression through the PI3K/AKT/mTOR signaling pathway, while statins inhibit ILF3 expression, potentially offering a new targeted therapy for gastric cancer.
Article
Biochemistry & Molecular Biology
Xiang Gao, Wenqu Jiang, Zunliang Ke, Qiwei Huang, Liang Chen, Guobin Zhang, Chao Li, Xiaojun Yu
Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
