Review
Chemistry, Multidisciplinary
Luanjing Li, Jiahe Wang, Shihan Xu, Chunxia Li, Biao Dong
Summary: This paper reviews the recent research progress and applications of metal ion fluorescent probes, and discusses the future development direction.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mikiko Vazquez-Nakagawa, Laura Rodriguez-Perez, Nazario Martin, M. Angeles Herranz
Summary: This study describes a method for preparing new chiral graphene quantum dots through chemical functionalization, and examines their supramolecular assembly using microscopy. Fluorescence studies show that the fibers stem from the pi-pi stacking of pyrenes and GQDs, along with the hydrogen bonding interactions of the amide groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Lena Golubewa, Tatsiana Kulahava, Aliona Klimovich, Danielis Rutkauskas, Ieva Matulaitiene, Renata Karpicz, Nikita Belko, Dmitri Mogilevtsev, Alena Kavalenka, Marina Fetisova, Petri Karvinen, Yuri Svirko, Polina Kuzhir
Summary: In this study, it is demonstrated that green fluorescence graphene quantum dots can detect the presence of hypochlorous acid and selectively detect reactive chlorine species produced by neutrophils. Changes in the fluorescence of GQDs under different conditions make them a promising sensing agent for biomedical applications.
Article
Chemistry, Multidisciplinary
Chang Liu, Qing Li, Haopeng Wang, Gefei Wang, Haixia Shen
Summary: This work presents a self-healing assembly method for preparing various fluorescent quantum dots (QDs)-loaded gels. The as-prepared gels exhibit pH sensitivity, satisfactory mechanical properties, and excellent self-healing properties. The integration of QDs with gels enables the fabrication of fluorescent composites, which show potential applications in LED devices. Additionally, the self-healing assembly method using QDs-loaded gels as building blocks allows for the construction of complex structures with different fluorescence, which can be used for sensing and encoding purposes.
Article
Chemistry, Multidisciplinary
Daniela Iannazzo, Claudia Espro, Angelo Ferlazzo, Consuelo Celesti, Caterina Branca, Giovanni Neri
Summary: This study investigated the potential of composites based on graphene quantum dots and crown ethers for detecting the concentration of sodium and potassium ions in biological fluids. The results demonstrated the superior properties of these composites, showing promise for the development of selective detection methods.
Article
Chemistry, Multidisciplinary
Mariangela Oggianu, Cristiana Figus, Suchithra Ashoka-Sahadevan, Noemi Monni, Daniela Marongiu, Michele Saba, Andrea Mura, Giovanni Bongiovanni, Claudia Caltagirone, Vito Lippolis, Carla Cannas, Enzo Cadoni, Maria Laura Mercuri, Francesco Quochi
Summary: The potential of silicon-based fluorescent platforms for trace toxic metal ion detection in aqueous environments was investigated, showing high sensitivity and selectivity, as well as good reversibility. The architecture allows tailoring of selectivity towards other metal ions by proper fluorophore selection.
Review
Chemistry, Inorganic & Nuclear
Guanghan Li, Zhenhua Liu, Wen Gao, Bo Tang
Summary: Graphene quantum dots (GQDs) with excellent optical properties, high specific surface area, large p-conjugated system, and modifiable edge groups have emerged as a star material for biomedical fluorescent sensors. Compared to small molecule fluorescent probes, GQDs based fluorescent sensors show good stability, water solubility, and chemical inertness. They can also be loaded with drugs or other materials for integrated visualization and treatment. This review summarizes the recent advances in GQDs based fluorescent sensors and highlights their potential in biomedical applications.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemical Research Methods
Manivannan Madhu, Chien-Min Chao, Chen-Yi Ke, Ming-Mu Hsieh, Wei-Lung Tseng
Summary: A triple-readout probe has been developed for the colorimetric, fluorescent, and fluorescence-lifetime sensing of alkaline phosphatase (ALP) using silver nanoparticles (AgNPs) formed on molybdenum disulfide quantum dots (MoS2 QDs). The probe shows high sensitivity and selectivity for the detection of target proteins in clinical samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Saman Sargazi, Iqra Fatima, Maria Hassan Kiani, Vahideh Mohammadzadeh, Rabia Arshad, Muhammad Bilal, Abbas Rahdar, Ana M. Diez-Pascual, Razieh Behzadmehr
Summary: Fluorescent-based bioprobes have unique attributes that make them suitable for creating highly sensitive nano-biosensors for detecting various biological and chemical agents. These sensors are superior to other analytical instrumentation techniques in terms of being biodegradable, eco-friendly, and more economical and cost-effective. This paper provides a comprehensive overview of the electrochemical sensors that use nanomaterials to detect biological macromolecules based on fluorescent emission spectra.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yunfeng Shi, Mengyue Wang, Linzhu Zhou, Xueqi Shen, Jinhao Wang, Nannan Mo, Guo Zhao, Su Yang, Xinyuan Zhu, Andrew M. Smith
Summary: A new strategy based on supramolecular self-assembly has been described for constructing fluorescent quantum dots (QDs) responsive to triethylamine. The encapsulation of QDs in a supramolecular self-assembly system shows promising prospects in bioimaging applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Engineering, Environmental
Yongming Guo, Yijia Zhang, Ting Li, Tao Tao
Summary: ZnO quantum dots (ZnO QDs) have been extensively developed and utilized in environmental sensing due to their biocompatibility and fluorescence properties. This review discusses the synthetic approaches, advantages, limitations, and sensing strategies of ZnO QDs, with a focus on their recent advances in fluorescent sensing of environmental contaminants. Challenges and future prospects are also highlighted in the last section.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Si Li, Xiao Guo, Maozhong Sun, Aihua Qu, Changlong Hao, Xiaoling Wu, Jun Guo, Chuanlai Xu, Hua Kuang, Liguang Xu
Summary: Nanotechnology has significantly advanced biological systems by leveraging the distinct properties of nanostructures, particularly the self-limiting self-assembly of supraparticles for creating biomimicking nanostructures with desired functionalities. This review highlights recent developments and achievements in colloidal supraparticles, emphasizing their application values in biological systems.
Article
Chemistry, Multidisciplinary
Peng Yang, Xin Zhou, Jianhua Zhang, Jian Zhong, Fang Zhu, Xianhu Liu, Zhipeng Gu, Yiwen Li
Summary: Fluorescent polymer dots (PDs) were successfully prepared from natural polyphenols via one-pot co-polymerization under mild conditions without the use of organic solvents or harsh chemicals. The resulting PDs exhibited good photostability and biocompatibility, as well as high selectivity towards copper ions. This green and facile strategy opens up new possibilities for the design and preparation of natural molecule-based PDs for biomedical and environmental applications.
Review
Chemistry, Analytical
Ajaypal Kaur, Komal Pandey, Ramandeep Kaur, Nisha Vashishat, Manpreet Kaur
Summary: This review article discusses the synthesis and application of carbon-based quantum dots and their nanocomposites as sensors. Different synthesis methods are categorized as top-down and bottom-up approaches, with a comparison of their advantages and disadvantages. The environmental applications of CQDs/GQDs nanocomposites and pristine quantum dots as sensors are presented in detail, along with recent advances and future prospects.
Review
Chemistry, Applied
Yongming Guo, Ruiqing Wang, Chengwei Wei, Yijin Li, Tiancheng Fang, Tao Tao
Summary: NO2- is commonly found in foods and the environment, and excessive intake poses serious hazards to human health. Traditional instrumental approaches for detection of NO2- are limited by expensive instruments and complicated operations. The emergence of carbon quantum dots (CQDs) provides a solution with their integrated merits, including easy fabrication, low-cost, high quantum yield, excellent photostability, tunable emission behavior, good water solubility, and low toxicity. This review presents the synthetic strategies of CQDs and highlights their advances in fluorescent detection of NO2-, while also discussing the challenges and perspectives in the field.
Article
Chemistry, Multidisciplinary
Qiao Zhang, Kai Xia, Meng Jiang, Qingting Li, Weigang Chen, Mingzhe Han, Wei Li, Rongqin Ke, Fei Wang, Yongxing Zhao, Yuehua Liu, Chunhai Fan, Hongzhou Gu
Summary: This study presents a new method called PECAN (paired-end cutting assisted by DNAzymes), which allows for the mass production of high-quality single-stranded DNA with arbitrary sequences. The method utilizes self-hydrolyzing DNAzymes to generate precursor DNA, which can then be amplified and processed to release large quantities of target DNA. PECAN offers high customizability, purity, and scalability, making it suitable for a wide range of applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Mengmeng Liu, Xiaoyu Zhang, Lulu Huang, Jie Li, Chunhai Fan, Yang Tian
Summary: This article reviews the evolution of DNA nanostructure-guided plasmon coupling architectures, including the introduction of DNA nanostructures and DNA modification on the surface of plasmonic nanoparticles.
Article
Chemistry, Multidisciplinary
Dandan Li, Jiang Li, Jiao Hu, Mingjie Tang, Peng Xiu, Yunchang Guo, Tunan Chen, Ning Mu, Lihua Wang, Xuehua Zhang, Guizhao Liang, Huabin Wang, Chunhai Fan
Summary: Understanding how A beta 42 oligomers affect neurons from a mechanobiological perspective is crucial for studying neurodegenerative diseases. Using atomic force microscopy (AFM), we quantitatively investigate the nanomechanical properties of neurons exposed to A beta 42 oligomers. We establish a method called heterogeneity-load-unload nano mechanics (HLUN) which allows us to comprehensively profile the mechanical properties of living neurons and correlate them with biological effects.
Article
Chemistry, Multidisciplinary
Lulu Huang, Xiuhai Mao, Jie Li, Qian Li, Jianlei Shen, Mengmeng Liu, Chunhai Fan, Yang Tian
Summary: By designing dual-emissive gold nanoparticles with varying spikiness, the interactions between spiky nanoparticles and cells were investigated. It was found that the nanospikes regulated myosin IIA recruitment at the cell membrane, enhancing cellular uptake efficiency. Moreover, the spiky nanoparticles facilitated endocytosis dynamics. These findings provide insights into the intracellular fate of nanoparticles and the development of theranostic nanocarriers.
Article
Chemistry, Multidisciplinary
Daoxia Guo, Xiaoyuan Ji, Hui Xie, Jia Ma, Chunchen Xu, Yanfeng Zhou, Nan Chen, Hui Wang, Chunhai Fan, Haiyun Song
Summary: Cancer-associated fibroblasts (CAFs) play a role in chemoresistance and immunosuppression, but direct depletion may lead to increased invasiveness and metastasis. Gemini-like targeting nanoparticles (NPs) have been designed to transform CAFs and eliminate cancer cells, enhancing drug susceptibility and immune cell infiltration. In mouse models of various resistant cancers, a single dose of these NPs resulted in improved chemosensitivity, immune activation, tumor regression, and long-term protection against tumor rechallenge.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chunchen Xu, Xiaoyuan Ji, Yanfeng Zhou, Yuchun Cheng, Daoxia Guo, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: A study introduces a novel approach to revitalize tumor-associated dendritic cells (TADCs) and enhance their anti-tumor response. This is achieved by using multilevel lipid rewiring nanoparticles to promote TADC maturation and restore their inflammatory cytokine production, cytotoxic T cell recruitment, and tumor inhibition.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Haipei Zhao, Xuehao Xiu, Mingqiang Li, Shaobo Dai, Mingyang Gou, Leyang Tao, Xiaolei Zuo, Chunhai Fan, Zhongqun Tian, Ping Song
Summary: Dynamic interactions of enzymes are important in regulating cellular metabolism. A super DNA-enzymes molecule was constructed for controlling and detecting metabolism. The programmable SDEM shows improved detection limit and reaction rate compared to free enzymes. The SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand for multiple cycles. An entropically driven catalytic assembly enables quick switching between different SDEMs for detecting different metabolisms on demand.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
News Item
Chemistry, Multidisciplinary
Ping Song, Chunhai Fan
Summary: A new high-dimensional microfluidic approach allows for the quantitative isolation of aptamers with customizable binding affinities, presenting a challenging yet promising method for constructing aptamers with desired target-binding affinities.
Article
Nanoscience & Nanotechnology
Fangfei Yin, Haipei Zhao, Shasha Lu, Juwen Shen, Min Li, Xiuhai Mao, Fan Li, Jiye Shi, Jiang Li, Baijun Dong, Wei Xue, Xiaolei Zuo, Xiurong Yang, Chunhai Fan
Summary: The article introduces a DNA-encoded molecular classifier that can classify multidimensional molecular clinical data and has been tested in prostate cancer patients.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kun Dai, Chen Gong, Yang Xu, Fei Ding, Xiaodong Qi, Xinyi Tu, Lu Yu, Xiaoguo Liu, Jiang Li, Chunhai Fan, Hao Yan, Guangbao Yao
Summary: This study presents a transcription-based approach to quantitatively integrate nucleoside analogue molecules into RNA nanostructures. The integrated RNA origami not only maintains its morphology and biostability, but also gains new biomedical functions, such as innate immune recognition after integrating epigenetic nucleoside analogues, and synergistic effects on tumor cell killing after integrating therapeutic nucleoside analogues. This research provides a promising method for the quantitative integration of functional nucleoside analogues into RNA nanostructures, offering valuable insights for the development of multifunctional RNA origamis.
Article
Multidisciplinary Sciences
Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Chenyun Sun, Qian Zhang, Lei Zhao, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang, Chunhai Fan
Summary: We demonstrate a general-purpose DNA integrated circuit (DIC) system by integrating multilayer DNA-based programmable gate arrays (DPGAs), which can be reconfigured and programmed to implement a wide range of circuits. We also show that DNA origami registers can control the asynchronous execution of cascaded DPGAs, and the integration of a DPGA with an analog-to-digital converter can be used for disease classification.
Article
Chemistry, Multidisciplinary
Qinqin Hu, Zongxuan Tong, Ayimukedisi Yalikong, Li-Ping Ge, Qiang Shi, Xinyu Du, Pu Wang, Xi-Yu Liu, Wuqiang Zhan, Xia Gao, Di Sun, Tong Fu, Dan Ye, Chunhai Fan, Jie Liu, Yun-Shi Zhong, Yi-Zhou Jiang, Hongzhou Gu
Summary: Biomarker discovery is crucial for understanding and diagnosing malignant diseases, but the lack of sensitive methods to identify rare disease-specific molecules remains a challenge. This study presents MORAC, a method that utilizes DNAzymes to identify candidate biomarkers with low abundance. By exploiting the catalysis and affinity of DNAzymes, previously unknown biomarkers with clear clinical value can be identified.
Editorial Material
Chemistry, Physical
Yu Chen, Gemma-Louise Davies, Anders Hagfeldt, Nicholas Kotov
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Multidisciplinary Sciences
Douglas G. Montjoy, Elizabeth A. K. Wilson, Harrison Hou, Joel D. Graves, Nicholas A. Kotov
Summary: By assembling spiky micro-nanoparticles of metal oxides into complex "hedgehog" particles (HPs) with enhanced dispersibility, effective photo-oxidation of liquid cyclohexane can be achieved, demonstrating the potential of these inorganic photocatalysts for "green" catalysis.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yuan Cao, Bingcheng Luo, Atif Javaid, Hong Ju Jung, Tao Ma, Chung-Man Lim, Ahmet Emre, Xiaohui Wang, Nicholas A. Kotov
Summary: This study investigates the mechanisms of charge storage in complex nanostructured materials using a model system of FeSe2 hedgehog particles (HPs). It was found that the HPs can accommodate a higher charge density and have improved charge storage capacity due to the hole transport and reversible atomic conformations of the FeSe2 layers. The dispersibility of the HPs also enables easy integration into energy storage devices.
