C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function

Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma

(2019) Manali Dimri et al.   HEPATOLOGY

Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer

(2018) Bei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition

(2017) Min Ye et al.   Oncotarget

C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

(2017) Yingjuan Fan et al.   Acta Pharmaceutica Sinica B

Dual Inhibition of Bcr-Abl and Hsp90 by C086 Potently Inhibits the Proliferation of Imatinib-Resistant CML Cells

(2014) L. Wu et al.   CLINICAL CANCER RESEARCH

The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma

(2014) QIURAN XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFκB in colon cancer cells and xenograft tumors

(2011) Chun Chen et al.   CANCER BIOLOGY & THERAPY

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

(2011) Hardik J Patel et al.   Expert Opinion on Drug Discovery

Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins

(2011) Yun Jeong Kim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis

(2009) Justine Rudner et al.   BIOCHEMICAL PHARMACOLOGY

1,5-Diaryl-3-oxo-1,4-pentadienes: A Case for Antineoplastics with Multiple Targets

(2009) U. Das et al.   CURRENT MEDICINAL CHEMISTRY

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

(2009) Shensi Shen et al.   JOURNAL OF CELL BIOLOGY

Pharmacological actions of curcumin in liver diseases or damage

(2009) Yadira Rivera-Espinoza et al.   LIVER INTERNATIONAL

Mortality Attributable to Smoking in China

(2009) Dongfeng Gu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hsp90 molecular chaperone: an open and shut case for treatment

(2008) Laurence H. Pearl et al.   BIOCHEMICAL JOURNAL

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis

(2008) Wei-Zhang Wang et al.   FEBS LETTERS

Hepatocellular carcinoma: Defining the place of surgery in an era of organ shortage

(2008) Adam Bartlett et al.   WORLD JOURNAL OF GASTROENTEROLOGY