Simvastatin effects on detoxification mechanisms in Danio rerio embryos

Statins: An undesirable class of aquatic contaminants?

(2016) Miguel M. Santos et al.   AQUATIC TOXICOLOGY

Effects of the pharmaceuticals diclofenac and metoprolol on gene expression levels of enzymes of biotransformation, excretion pathways and estrogenicity in primary hepatocytes of Nile tilapia (Oreochromis niloticus)

(2015) Frederike Gröner et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Toxicity screening of Diclofenac, Propranolol, Sertraline and Simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays

(2015) Sílvia Ribeiro et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment

(2015) André M.P.T. Pereira et al.   ENVIRONMENTAL RESEARCH

Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of nifedipine in rats: Possible role of P-gp and CYP3A4 inhibition by HMG-CoA reductase inhibitors

(2015) Chong-Ki Lee et al.   Pharmacological Reports

Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range

(2014) Teresa Neuparth et al.   AQUATIC TOXICOLOGY

Effects of triclosan on the detoxification system in the yellow catfish (Pelteobagrus fulvidraco): Expressions of CYP and GST genes and corresponding enzyme activity in phase I, II and antioxidant system

(2014) Peijia Ku et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Current advances on ABC drug transporters in fish

(2014) Till Luckenbach et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Ecotoxicity and environmental risk assessment of pharmaceuticals and personal care products in aquatic environments and wastewater treatment plants

(2014) Sheyla Andrea Ortiz de García et al.   ECOTOXICOLOGY

To Bind or Not To Bind: The Taxonomic Scope of Nuclear Receptor Mediated Endocrine Disruption in Invertebrate Phyla

(2014) L. Filipe C. Castro et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Histopathological lesions, P-glycoprotein and PCNA expression in zebrafish (Danio rerio) liver after a single exposure to diethylnitrosamine

(2014) Sandrine P. Machado et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Validation of reference genes for RT-qPCR analysis of CYP4T expression in crucian carp

(2014) Fei Mo et al.   GENETICS AND MOLECULAR BIOLOGY

ABC transporters in fish species: a review

(2014) Marta Ferreira et al.   Frontiers in Physiology

Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

(2013) Stephan Fischer et al.   BMC BIOLOGY

The first demonstration of CYP1A and the ABC protein(s) gene expression and activity in European seabass (Dicentrarchus labrax) primary hepatocytes

(2013) Marta Ferreira et al.   CHEMOSPHERE

Normalization strategies for gene expression studies by real-time PCR in a marine fish species, Scophthalmus maximus

(2013) R. Urbatzka et al.   Marine Genomics

ATP-dependent transport of statins by human and rat MRP2/Mrp2

(2013) Lucy C.J. Ellis et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zebrafish (Danio rerio) life-cycle exposure to chronic low doses of ethinylestradiol modulates p53 gene transcription within the gonads, but not NER pathways

(2012) J. Soares et al.   ECOTOXICOLOGY

Atorvastatin up-regulate toxicologically relevant genes in rainbow trout gills

(2012) Kathrin Sabine Ellesat et al.   ECOTOXICOLOGY

ABC transporters, CYP1A and GSTα gene transcription patterns in developing stages of the Nile tilapia (Oreochromis niloticus)

(2012) Joana Costa et al.   GENE

Differential Selectivity of Efflux Transporter Inhibitors in Caco-2 and MDCK–MDR1 Monolayers: A Strategy to Assess the Interaction of a New Chemical Entity with P-gp, BCRP, and MRP2

(2012) Kirsten Mease et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line

(2012) Britt Wassmur et al.   TOXICOLOGY IN VITRO

Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio

(2011) Mohamed Banni et al.   BIOMETALS

Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals

(2011) Yong Long et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Gene expression analysis of ABC efflux transporters, CYP1A and GSTα in Nile tilapia after exposure to benzo(a)pyrene

(2011) Joana Costa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Species-dependent sensitivity to contaminants: An approach using primary hepatocyte cultures with three marine fish species

(2011) Kathrin Sabine Ellesat et al.   MARINE ENVIRONMENTAL RESEARCH

Effects of HMG-CoA Reductase Inhibitors on the Pharmacokinetics of Losartan and Its Main Metabolite EXP-3174 in Rats: Possible Role of CYP3A4 and P-gp Inhibition by HMG-CoA Reductase Inhibitors

(2011) Si-Hyung Yang et al.   PHARMACOLOGY

Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)

(2010) Jens C. Otte et al.   AQUATIC TOXICOLOGY

Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants

(2010) Melissa Faria et al.   AQUATIC TOXICOLOGY

Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish

(2010) Jenna Corcoran et al.   CRITICAL REVIEWS IN TOXICOLOGY

A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells

(2010) Joanna Kopecka et al.   JOURNAL OF CONTROLLED RELEASE

Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

(2009) Michael J. Knauer et al.   CIRCULATION RESEARCH

Early zebrafish development: It's in the maternal genes

(2009) Elliott W Abrams et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The maternal-to-zygotic transition: a play in two acts

(2009) W. Tadros et al.   DEVELOPMENT

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells

(2009) Daisuke Yamasaki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

(2009) Lúcia H.M.L.M. Santos et al.   JOURNAL OF HAZARDOUS MATERIALS

Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish

(2009) Alicia R. Timme-Laragy et al.   TOXICOLOGICAL SCIENCES

Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1

(2008) Daniel Caminada et al.   AQUATIC TOXICOLOGY

Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport†

(2008) Paul D. W. Eckford et al.   BIOCHEMISTRY

Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment

(2008) Amy T McCurley et al.   BMC MOLECULAR BIOLOGY

Statin-Induced Inhibition of MCF-7 Breast Cancer Cell Proliferation is Related to Cell Cycle Arrest and Apoptotic and Necrotic Cell Death Mediated by an Enhanced Oxidative Stress

(2008) Claudia A. Sánchez et al.   CANCER INVESTIGATION

Assessment of pollution along the Northern Iberian shelf by the combined use of chemical and biochemical markers in two representative fish species

(2008) Denise Fernandes et al.   ENVIRONMENTAL POLLUTION

Efflux Transporters: Newly Appreciated Roles in Protection against Pollutants

(2008) David Epel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of the statin antihyperlipidemic agent simvastatin on grass shrimp,Palaemonetes pugio

(2008) Peter B. Key et al.   ENVIRONMENTAL TOXICOLOGY

Metal accumulation and oxidative stress responses in, cultured and wild, white seabream from Northwest Atlantic

(2008) M FERREIRA et al.   SCIENCE OF THE TOTAL ENVIRONMENT