Article
Chemistry, Physical
Natalia Bulina, Denis K. Rybin, Svetlana Makarova, Dina Dudina, Igor S. Batraev, Alexey Utkin, Igor Yu Prosanov, Mikhail Khvostov, Vladimir Yu Ulianitsky
Summary: Hydroxyapatite (HA) is a suitable mineral for bone tissue engineering and coating metallic implants to enhance their biocompatibility and osteoinductive properties. Deposition of HA coatings on medical titanium alloy implants using detonation spraying technique showcased the potential for producing HA coatings on implants with complex geometries.
Article
Materials Science, Ceramics
Nuzul Ficky Nuswantoro, Menkher Manjas, Netti Suharti, Dian Juliadmi, Hidayatul Fajri, Djong Hon Tjong, Jon Affi, Mitsuo Niinomi, Gunawarman
Summary: The study discusses the hydroxyapatite coating on a titanium alloy to enhance biocompatibility and bioactivity, demonstrating its impact on osseointegration and inflammatory reactions in bone tissue through experiments.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Mona Sari, Nicholas Adi Kristianto, Chotimah, Ika Dewi Ana, Yusril Yusuf
Summary: Carbonated hydroxyapatite based on abalone mussel shells was successfully synthesized and used for coating on a Titanium alloy. The electrophoretic deposition dip coating method was employed to coat the hydroxyapatite on the Titanium alloy surface, creating a potential coating for bone implant applications.
Article
Materials Science, Multidisciplinary
Xuan Pei, Linnan Wang, Changchun Zhou, Lina Wu, Haoyuan Lei, Shiqi Fan, Zhimou Zeng, Zhipeng Deng, Qingquan Kong, Qing Jiang, Jie Liang, Yueming Song, Yujiang Fan, Maling Gou, Xingdong Zhang
Summary: This study investigates the influence of heterogeneous microenvironments on bone regeneration through the design and simulation of bionic porous structures. Experimental results indicate that quasi-homogeneous structures with irregular topology and semi-heterogeneous structures promote osteogenesis, which is crucial for the development of new orthopedic implants.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Jithin Vishnu, Andrea Voss, Volker Hoffmann, Ludovico Andrea Alberta, Adnan Akman, Balakrishnan Shankar, Annett Gebert, Mariana Calin
Summary: Low-modulus beta-type Ti-45Nb alloy is a promising implant material with good mechanical biocompatibility, non-toxicity, and outstanding corrosion resistance. This study proposes a novel method to develop bioactive and antibacterial surfaces on Ti-45Nb alloy by incorporating gallium ions into hydroxyapatite. The results show that the combination of gallium and hydroxyapatite has great potential for local delivery of gallium ions and consequent antibacterial protection during bone regeneration.
Article
Materials Science, Multidisciplinary
Jinying Du, Guowei Wang, Dan Song, Jinghua Jiang, Hongbing Jiang, Jun Gao
Summary: This study successfully developed a new guided bone regeneration (GBR) membrane material by hydrothermal technique. The hydroxyapatite coating significantly improved the anticorrosion/biodegradation performance of the alloy substrate and promoted cell adhesion and proliferation.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Materials Science, Multidisciplinary
Puneet Bansal, Gurpreet Singh, Hazoor Singh Sidhu
Summary: Plasma-sprayed zinc oxide reinforced hydroxyapatite coatings were developed on a titanium alloy substrate at different weight percentages of ZnO powder to enhance mechanical properties and corrosion resistance. Increasing ZnO reinforcement led to higher surface hardness and lower surface roughness. All coated samples exhibited hydrophilic behavior, with the HA+12% ZnO coating showing the highest corrosion resistance among them.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Hsueh-Chuan Hsu, Shih-Ching Wu, Chien-Yu Lin, Wen-Fu Ho
Summary: Hydroxyapatite/chitosan (HA/CS) composite coatings were prepared on the surface of low-modulus Ti-25Nb-8Sn alloy by hydrothermal treatment to improve the surface bioactivity. The experimental results showed that the HA/CS composite coatings fabricated at various temperatures through hydrothermal treatment exhibited excellent bioactivity.
Article
Materials Science, Coatings & Films
Venkata Sundeep Seesala, Ragavi Rajasekaran, Atul Kumar Ojha, Arjun Mahato, Roja Rani Korrayi, Bodhisatwa Das, Satya Prasad Venugopal, Shibayan Roy, Santanu Dhara
Summary: A ceramic dough processing-based composite slurry was used to form a thin gradient coating on a zirconia dental screw implant, which had HAp and zirconia. The coating had a homogeneous distribution of a secondary phase and increased roughness, but minimal compromise on strength. The coating survived a scratch test with a normal load >70 N without any significant spalling or delamination. This approach is a compatible and promising solution for currently available bio-inert zirconia implants.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Chemistry, Physical
Limin Qu, Xiangzhou Li, Jun Zhou, Kairui Cao, Qiuen Xie, Peng Zhou, Wei Qian, Yanhong Yang
Summary: This study developed a dual-functional coating with antibacterial and antifouling properties to combat biofilm infections on implants. The coating effectively inhibited bacterial growth and biofilm formation, and showed favorable biocompatibility.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Byungmin Ahn
Summary: Ti-6Al-4V alloy was prepared using selective laser melting (SLM) method and subjected to heat treatment in this study. The results showed that heat treated samples exhibited a reduction in defects, a change in morphology of the alpha'-martensite, a significant decrease in strength, but an improvement in elongation. An optimal combination of strength and elongation was found at 900°C.
Article
Chemistry, Multidisciplinary
Nicola De Angelis, Luca Solimei, Claudio Pasquale, Lorenzo Alvito, Alberto Lagazzo, Fabrizio Barberis
Summary: Bone augmentation procedures using titanium meshes were investigated in this study. Testing showed differences in bending performance between perforated and non-perforated samples, but no significant alterations were observed in the microscopic analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Coatings & Films
S. Ferraris, G. Orlygsson, C. H. Ng, G. Riccucci, S. Spriano
Summary: Coating titanium with chitosan is a promising method for reducing the infection risk and modulating the inflammatory response of bone implants. This research tested two titanium surfaces and employed three coating strategies. The chemically pretreated surface showed the best coating results and interface stability.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
In-Oh Choi, Ji-Su Oh, Sang-Joun Yu, Byung-Ock Kim, Won-Pyo Lee
Summary: The study evaluated the efficacy of using three-dimensional preformed titanium mesh for non-contained horizontal defects in guided bone regeneration, showing significant hard tissue gain rates in all three groups, with better results observed in patients using cross-linked collagen membranes in combination with the titanium mesh.
APPLIED SCIENCES-BASEL
(2021)
Review
Engineering, Biomedical
A. Kavitha Sri, C. Arthi, N. R. Neya, G. S. Hikku
Summary: Regenerative medicine offers hope for reforming defective organs, particularly bones, through the use of tissue engineering technology. Scaffold materials, such as nano-HA/collagen complex that support cell attachment and growth, have shown promise in bone regeneration. Recent studies have found that nano-HA exhibits higher cell adherence and subsequent growth, making it an ideal scaffold material for minimizing the limitations of conventional bone regeneration methods. This review focuses on the use and fabrication of nano-HA/collagen complex as a scaffold material for bone regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Ping Song, Changchun Zhou, Hongyuan Fan, Boqing Zhang, Xuan Pei, Yujiang Fan, Qing Jiang, Ruiying Bao, Qing Yang, Zhihong Dong, Xingdong Zhang
COMPOSITES PART B-ENGINEERING
(2018)
Article
Engineering, Multidisciplinary
Boqing Zhang, Xuan Pei, Ping Song, Huan Sun, Huiyong Li, Yujiang Fan, Qing Jiang, Changchun Zhou, Xingdong Zhang
COMPOSITES PART B-ENGINEERING
(2018)
Article
Engineering, Multidisciplinary
Li Zhao, Xuan Pei, Lihua Jiang, Cheng Hu, Jianxun Sun, Fei Xing, Changchun Zhou, Yujiang Fan, Xingdong Zhang
COMPOSITES PART B-ENGINEERING
(2019)
Article
Engineering, Biomedical
Xuan Pei, Lina Wu, Changchun Zhou, Hongyuan Fan, Maling Gou, Zhengyong Li, Boqing Zhang, Haoyuan Lei, Huan Sun, Jie Liang, Qing Jiang, Yujiang Fan, Xingdong Zhang
Summary: Fabricating personalized titanium scaffolds that mimic the osteocyte microenvironment is challenging due to complex geometrical cues. This study designed and produced titanium scaffolds with diamond-like structures to trigger osteocyte adhesion and migration behavior. The research also explored the effects of different geometric cues and implantation sites on bone regeneration, highlighting significant differences in in vivo experimental results.
Article
Materials Science, Biomaterials
Haoyuan Lei, Tao Yi, Hongyuan Fan, Xuan Pei, Lina Wu, Fei Xing, Mingxin Li, Lei Liu, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: Customization of porous scaffolds with different micro-topological structures can be achieved by adjusting 3D printing parameters. The structure of the scaffolds significantly impacts cell adhesion and proliferation, with regularly arranged pores and pore sizes suitable for cells playing a crucial role in regulating cell behavior.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Boqing Zhang, Ling Wang, Ping Song, Xuan Pei, Huan Sun, Lina Wu, Changchun Zhou, Kefeng Wang, Yujiang Fan, Xingdong Zhang
Summary: This study successfully combined PLLH/nHA composite with FDM technology to prepare porous bone repair scaffolds. The scaffolds showed good printing smoothness and accuracy, suitable mechanical properties, and good osteogenic properties.
MATERIALS & DESIGN
(2021)
Correction
Engineering, Biomedical
Xuan Pei, Lina Wu, Changchun Zhou, Hongyuan Fan, Maling Gou, Zhengyong Li, Boqing Zhang, Haoyuan Lei, Huan Sun, Jie Liang, Qing Jiang, Yujiang Fan, Xingdong Zhang
Article
Materials Science, Multidisciplinary
Xuan Pei, Linnan Wang, Changchun Zhou, Lina Wu, Haoyuan Lei, Shiqi Fan, Zhimou Zeng, Zhipeng Deng, Qingquan Kong, Qing Jiang, Jie Liang, Yueming Song, Yujiang Fan, Maling Gou, Xingdong Zhang
Summary: This study investigates the influence of heterogeneous microenvironments on bone regeneration through the design and simulation of bionic porous structures. Experimental results indicate that quasi-homogeneous structures with irregular topology and semi-heterogeneous structures promote osteogenesis, which is crucial for the development of new orthopedic implants.
MATERIALS & DESIGN
(2022)
Article
Engineering, Environmental
Lina Wu, Xuan Pei, Boqing Zhang, Zixuan Su, Xingyu Gui, Canyu Gao, Likun Guo, Hongyuan Fan, Qing Jiang, Li Zhao, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: In this study, personalized porous bone tissue engineering scaffolds were fabricated by 3D printing, and functionalized nanorod morphologies were controllably fabricated. The influence of nanorods geometrical cues on cellular behaviors and the mechanics of triggered osteogenesis were studied. The results provided evidence that the surface nano-scale morphology triggered signals for promoting osteogenic differentiation. In vivo experiments showed that the 3D printed scaffolds with a nanorod coating promoted bone regeneration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Haitao Peng, Tingxian Ling, Yao Zhang, Tianhang Xie, Xuan Pei, Kai Zhou, Anjing Chen, Jiali Chen, Xiangdong Zhu, Xingdong Zhang, Zongke Zhou
Summary: We fabricated biphasic calcium phosphate ceramics with nanowhisker structures and found that they significantly facilitated large-segment bone defect repair by promoting bone regeneration and scaffold resorption. Our in vitro and in vivo experiments showed that the nanowhisker structures could induce the early switch of macrophage phenotype from M1 to M2, resulting in accelerated osteoclastogenesis and osteogenesis. These findings provide new insights into the designing of immunomodulatory tissue engineering biomaterials for treating large-segment bone defects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Mechanics
Xuan Pei, Linnan Wang, Lina Wu, Haoyuan Lei, Pin Feng, Chen Fan, Zhigang Zhou, Lei Wang, Ming Liu, Changchun Zhou, Qingquan Kong, Yujiang Fan
Summary: A heterogeneous porous cage was designed to avoid intervertebral cage subsidence and promote spinal fusion. Finite element analysis was used to predict stress distribution, and parametrical modeling was employed to customize the porous structure. The experiment results showed that the heterogeneous structure accelerated bone tissue ingrowth and promoted osteointegration and fusion.
COMPOSITE STRUCTURES
(2023)
Article
Nanoscience & Nanotechnology
Wenzhao Wang, Pan Liu, Boqing Zhang, Xingyu Gui, Xuan Pei, Ping Song, Xia Yu, Zhengdong Zhang, Changchun Zhou
Summary: The FDM-printed PLA/nano 0-TCP composite scaffolds with personalized porosity and shape demonstrated superior osteogenic ability, biocompatibility, and bone repair capability in vivo compared to pure PLA. The combination of biodegradable PLA and bioactive nano 0-TCP ceramics improved the overall biological performance of the composites, providing a promising strategy for treating large bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Xuan Pei, Linnan Wang, Lina Wu, Haoyuan Lei, Zhimou Zeng, Lei Wang, Changchun Zhou, Xi Yang, Yueming Song, Yujiang Fan
Summary: This research proposes a modified hydrothermal approach to construct a bioactive hydroxyapatite coating inside the porous structure of a 3D printed porous titanium cage. The results suggest that hydroxyapatite enhances the cells physical sensing system, thereby improving bone growth and fusion ability of the titanium/hydroxyapatite cage.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Biomaterials
Ping Song, Cheng Hu, Xuan Pei, Jianxun Sun, Huan Sun, Lina Wu, Qing Jiang, Hongyuan Fan, Bangcheng Yang, Changchun Zhou, Yujiang Fan, Xingdong Zhang
JOURNAL OF MATERIALS CHEMISTRY B
(2019)