Nanomedicine Enables Drug-Potency Activation with Tumor Sensitivity and Hyperthermia Synergy in the Second Near-Infrared Biowindow

Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

(2020) Yuya Terashima et al.   Nature Communications

Pulsed Microwave-Pumped Drug-Free Thermoacoustic Therapy by Highly Biocompatible and Safe Metabolic Polyarginine Probes

(2019) Shaodong Zhai et al.   NANO LETTERS

Targeted Transmembrane Delivery of Ca2+ via FA-Nanogel for Synergistically Enhanced Chemotherapy

(2019) Shan-Wen Hu et al.   ACS Applied Materials & Interfaces

Mitochondrial Surface Engineering for Multidrug Resistance Reversal

(2019) Wei Chen et al.   NANO LETTERS

Photodegradable CuS SERS Probes for Intraoperative Residual Tumor Detection, Ablation, and Self-Clearance

(2019) Yuanyuan Qiu et al.   ACS Applied Materials & Interfaces

Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition

(2019) Wencheng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Yolk–Shell Structured Au Nanostar@Metal–Organic Framework for Synergistic Chemo-photothermal Therapy in the Second Near-Infrared Window

(2019) Xiaoran Deng et al.   NANO LETTERS

Nanomedicine Fabricated from A Boron-dipyrromethene (BODIPY)-Embedded Amphiphilic Copolymer for Photothermal-Enhanced Chemotherapy

(2019) Jie Shen et al.   ACS Biomaterials-Science & Engineering

Erythrocyte–Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma

(2018) Dongdong Wang et al.   ACS Nano

Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow

(2018) Xiaoxia Han et al.   ACS Nano

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Simple construction of Cu2−xS:Pt nanoparticles as nanotheranostic agent for imaging-guided chemo-photothermal synergistic therapy of cancer

(2018) Lile Dong et al.   Nanoscale

Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy

(2018) Ben Shi et al.   NANO LETTERS

Phase-Change Material Packaged within Hollow Copper Sulfide Nanoparticles Carrying Doxorubicin and Chlorin e6 for Fluorescence-Guided Trimodal Therapy of Cancer

(2018) Qian Li et al.   ACS Applied Materials & Interfaces

Fe3+-Induced Synchronous Formation of Composite Hydrogels for Effective Synergistic Tumor Therapy in NIR-I/II Biowindows

(2018) Jiulong Zhao et al.   ACS Applied Materials & Interfaces

Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers

(2018) Wu Chen et al.   ACS Applied Materials & Interfaces

Peptide-Guided System with Programmable Subcellular Translocation for Targeted Therapy and Bypassing Multidrug Resistance

(2018) Yuanyuan Zhu et al.   ANALYTICAL CHEMISTRY

Switching between Plasmonic and Fluorescent Copper Sulfide Nanocrystals

(2017) Ward van der Stam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows

(2017) Han Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs

(2017) Yanbin Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced reactive oxygen species through direct copper sulfide nanoparticle-doxorubicin complexation

(2017) Yajuan Li et al.   NANOTECHNOLOGY

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles

(2016) Isabel Ortiz de Solorzano et al.   ACS Applied Materials & Interfaces

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

(2016) Guanying Chen et al.   CHEMICAL REVIEWS

Using an Old Drug to Target a New Drug Site: Application of Disulfiram to Target the Zn-Site in HCV NS5A Protein

(2016) Yu-Ming Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A second look: Efforts to repurpose old drugs against Zika cast a wide net

(2016) Ellie Kincaid   NATURE MEDICINE

A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

(2016) Zhengze Yu et al.   Chemical Science

A Copper-Mediated Disulfiram-Loaded pH-Triggered PEG-Shedding TAT Peptide-Modified Lipid Nanocapsules for Use in Tumor Therapy

(2015) Ling Zhang et al.   ACS Applied Materials & Interfaces

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer

(2015) Jennifer L. Allensworth et al.   Molecular Oncology

Nanoscale materials for hyperthermal theranostics

(2015) Bennett E. Smith et al.   Nanoscale

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Solid–Solid Phase Transformations Induced through Cation Exchange and Strain in 2D Heterostructured Copper Sulfide Nanocrystals

(2014) Don-Hyung Ha et al.   NANO LETTERS

A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity

(2013) Liangran Guo et al.   ACS Nano

A Plasmon-Assisted Optofluidic (PAOF) System for Measuring the Photothermal Conversion Efficiencies of Gold Nanostructures and Controlling an Electrical Switch

(2013) Jie Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper Sulfide Nanocrystals with Tunable Composition by Reduction of Covellite Nanocrystals with Cu+ Ions

(2013) Yi Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseases

(2012) Hongkang Mei et al.   DRUG DISCOVERY TODAY

Hollow Copper Sulfide Nanoparticle-Mediated Transdermal Drug Delivery

(2012) Samy Ramadan et al.   Small

Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram)

(2011) Boris Cvek   DRUG DISCOVERY TODAY

Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells

(2011) Saverio Tardito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper Selenide Nanocrystals for Photothermal Therapy

(2011) Colin M. Hessel et al.   NANO LETTERS

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

(2009) Xiaoxia Guo et al.   CANCER LETTERS